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This book contains 26 papers describing research in the do- main of Artificial Intelligence in Medicine. The papers are grouped around the following themes: Methodology, knowledge representation, clinical applications, modelling, uncertain- ty management, knowledge acquisition, and the user perspec- tive. The book gives an overview of the current state of AI in medicine research in Europe. It presents several techni- ques and methods that are likely to play an important role in future applications. In the section on clinical applica- tions not only existing systems are described, but results of evaluation studies are presented as well.

This book constitutes the refereed proceedings of the Third International Workshop on Machine Learning in Medical Imaging, MLMI 2012, held in conjunction with MICCAI 2012, in Nice, France, in October 2012. The 33 revised full papers presented were carefully reviewed and selected from 67 submissions. The main aim of this workshop is to help advance the scientific research within the broad field of machine learning in medical imaging. It focuses on major trends and challenges in this area, and it presents work aimed to identify new cutting-edge techniques and their use in medical imaging.

This book contains the proceedings of the conference ANNIMAB-l, held 13-16 May 2000 in Goteborg, Sweden. The conference was organized by the Society for Artificial Neural Networks in Medicine and Biology (ANNIMAB-S), which was established to promote research within a new and genuinely cross-disciplinary field. Forty-two contributions were accepted for presentation; in addition to these, S invited papers are also included. Research within medicine and biology has often been characterised by application of statistical methods for evaluating domain specific data. The growing interest in Artificial Neural Networks has not only introduced new methods for data analysis, but also opened up for development of new models of biological and ecological systems. The ANNIMAB-l conference is focusing on some of the many uses of artificial neural networks with relevance for medicine and biology, specifically: • Medical applications of artificial neural networks: for better diagnoses and outcome predictions from clinical and laboratory data, in the processing of ECG and EEG signals, in medical image analysis, etc. More than half of the contributions address such clinically oriented issues. • Uses of ANNs in biology outside clinical medicine: for example, in models of ecology and evolution, for data analysis in molecular biology, and (of course) in models of animal and human nervous systems and their capabilities. • Theoretical aspects: recent developments in learning algorithms, ANNs in relation to expert systems and to traditional statistical procedures, hybrid systems and integrative approaches.

This book presents a sample of research on knowledge-based systems in biomedicine and computational life science. The contributions include: personalized stress diagnosis system, image analysis system for breast cancer diagnosis, analysis of neuronal cell images, structure prediction of protein, relationship between two mental disorders, detection of cardiac abnormalities, holistic medicine based treatment and analysis of life-science data.

This book constitutes the refereed proceedings of the 13th Conference on Artificial Intelligence in Medicine, AIME 2011, held in Bled, Slovenia, in July 2011. The 42 revised full and short papers presented together with 2 invited talks were carefully reviewed and selected from 113 submissions. The papers are organized in topical sections on knowledge-based systems; data mining; special session on AI applications; probabilistic modeling and reasoning; terminologies and ontologies; temporal reasoning and temporal data mining; therapy planning, scheduling and guideline-based care; and natural language processing.

The incursion of information and communication technologies (ICT) in health care entails evident bene?ts at the levels of security and e?ciency that improve not only the quality of life of the patients, but also the quality of the work of the health care professionals and the costs of national health care systems. Leaving research approaches aside, the analysis of ICT in health care shows an evo- tion from the initial interest in representing and storing health care data (i. e., electronic health care records) to the current interest of having remote access to electronic health care systems, as for example HL7 initiatives or telemedicine. This sometimes imperceptible evolution can be interpreted as a new step of the progress path of health care informatics, whose next emerging milestone is the convergenceof current solutions with formal methods for health care kno- edge management. In this sense, K4CARE is a European project aiming at contributing to this progress path. It is centered on the idea that health care knowledge rep- sented in a formal waymay favor the treatment of home care patients in modern societies. The project highlights several aspects that are considered relevant to the evolution of medical informatics: health care knowledge production, health care knowledge integration, update, and adaptation, and health care intelligent systems.