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This book gathers selected contributions by top Portuguese and international researchers in the field of Operations Research, presented at the 19th Congress of APDIO (Portuguese Association of Operational Research). The papers address a broad range of complex real-world problems, which are approached using recent theoretical techniques. Of particular interest are the applications of e.g. linear, nonlinear and mixed-integer programming, multiobjective optimization, metaheuristics and hybrid heuristics, multicriteria decision analysis, data envelopment analysis, clustering techniques and decision support systems, in such varied contexts as: supply chain management, scheduling problems, production management, logistics, energy, finance and healthcare. This conference, organized by APDIO and held in Aveiro, Portugal in September 2018, offered an ideal opportunity to discuss the latest developments in this field and to build new bridges between academic researchers and practitioners. Summarizing the outcomes, this book offers a valuable tool for all researchers, students and practitioners who wish to learn about the latest trends in this field.