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Vor dem Hintergrund der Resistenzentwicklung als globale Bedrohung und dem Mangel an wirksamen neuen Antiinfektiva wird es immer wichtiger, dass Antiinfektiva nur dann verordnet werden, wenn eine behandlungsbedürftige Infektion vorliegt. Die Kommission ART beim RKI hat im Mai 2020 in ihrem Positionspapier „Strukturelle und personelle Voraussetzungen für die Sicherung einer rationalen Antiinfektivaverordnung in Krankenhäusern“ dargestellt, dass mit Antibiotic Stewardship durch interdisziplinär abgestimmte Maßnahmen auf der Basis wissenschaftlicher Evidenz der Einsatz von Antiinfektiva verbessert werden kann. Dafür sind zunehmend infektiologische Spezialkenntnisse erforderlich. Jedem, der Antibiotika verordnet, sollte bewusst sein, dass eine Infektion umso erfolgreicher behandelt werden kann, je schneller das richtige Präparat in der korrekten Dosierung und Dauer für die jeweilige Infektion ausgewählt wird. Gleichzeitig muss eine Übertherapie vermieden werden, um die Wirkung von Reserveantibiotika für Schwerkranke zu erhalten. Die Antibiotika Fibel vermittelt kompakt und übersichtlich die wichtigsten Informationen zur kalkulierten antiinfektiven Therapie häufiger Infektionen und zur perioperativen Antibiotikaprophylaxe sowohl für die Klinik als auch für die ambulante Behandlung auf der Basis aktueller Leitlinien. Die 9. Auflage wurde aktualisiert und ergänzt.

In this monograph, journalist Rinke van den Brink takes a closer look at the limitations and risks of today's antibiotic use. Though all developed societies have grown accustomed to successfully treating bacterial infections with these wonder drugs, the author focuses on the increasing number of antibiotic-resistant infections. By examining recent mass outbreaks, readers will gain a better understanding of the global impact of antimicrobial resistance – one of the most serious public health threats today. Following this somewhat disquieting review of the status quo, interviews with a number of specialists provide an outlook on possible solutions. In a world that is more connected than ever, partnerships between different healthcare systems are becoming all the more important. Rinke van den Brink uses the example of a border-spanning collaboration between the Netherlands and Germany to demonstrate how effective lines of communication can be established. The book offers a wealth of useful background information for healthcare personnel. Not only does it share insights into the functional microbe-antibiotic relationship; it also discusses how clinics can effectively address outbreaks, helping readers to learn from past experiences and develop effective new strategies.

Rationale Antibiotikatherapie

Kucers'The Use of Antibiotics is the definitive, internationally-authored reference, providing everything that the infectious diseases specialist and prescriber needs to know about antimicrobials in this vast and rapidly developing field. The much-expanded Seventh Edition comprises 4800 pages in 3 volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into four sections - antibiotics, anti-fungal drugs, anti-parasitic drugs, and anti-viral drugs - and is highly structured for ease of reference.Each chapter is organized in a consistent format, covering susceptibility, formulations and dosing (adult and pediatric), pharmacokinetics and pharmacodynamics, toxicity, and drug distribution, with detailed discussion regarding clinical uses - a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with expert contributors representing Europe, Africa, Asia, Australia, South America, the US, and Canada, the Seventh Edition adopts a truly global approach. It remains invaluable for anyone using antimicrobial agents in their clinical practice and provides, in a systematic and concise manner, all the information required when prescribing an antimicrobial to treat infection.

Antibiotic resistance in bacteria is rapidly becoming a major concern of medical practitioners worldwide. In fact, unless it is dealt with as a matter of urgency, we shall return to the ‘Dark Ages of Medicine'as the British Prime Minister has recently warned. This book vividly paints the scenario before the ‘germ theory'was conceived, and at a time when antimicrobials and anti-parasite agents were not even envisaged. How were the cause and management of infections viewed and treatment implemented, both in Britain and in tropical countries? Should antibiotic resistance become absolute, it is possible that humanity throughout the world will be faced with a major catastrophe and will thus be plunged back to a bygone era.

This book is based on Hans Zahner's Biologie der Antibiotica, published in 1965. There is a vast literature on antibiotics, covering chemical, phar­ macological, and clinical aspects. We have made no attempt to cover this literature comprehensively. Our effort is directed toward discuss­ ing antibiotics as biological agents. They are substances produced by living cells, yet they are able to inhibit the growth of living cells - in many cases even the cells that produce them. We have taken this apparent biological paradox as our point of departure and have tried to look in this light at the production of antibiotics and at their mode of action. In a sense antibiotics are comparable to mutations. They are useful as tools in the study of metabolism by blocking specific reactions. At the same time their mode of origin and their effects on the organisms that produce them are interesting problems in their own right. We have tried to incorporate both aspects into our consider­ ations. This little book, designed for biology students and medical stu­ dents, provides them with a framework into which to fit more specialized and detailed information on antibiotics.

This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi