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Life's Blood: The Story of Hemoglobin encompasses the entire clinically relevant story of hemoglobin, the only molecule we have that captures oxygen from the air we breathe and delivers it to our tissues to generate the energy without which we would not exist. Dr. Rosove covers first the discoveries of oxygen, hemoglobin, and circulation of the blood, then the structure and function of human hemoglobin, together with comparisons to other oxygen transporters in the animal kingdom. He examines the red blood cell and how it protects hemoglobin, with an in-depth look at malaria and the hemoglobin and red cell mutations malaria forced us to make defending ourselves against it, particularly sickle cell disease and the thalassemias. The author also explores adaptations to the oxygen-poor environment of high altitude; lessons from freak hemoglobin mutations; hemoglobin toxins including carbon monoxide and chemicals and drugs that cause oxidant damage; and the quest for a hemoglobin substitute. Life's Blood is a comprehensive resource for physicians, nurses, and other health professionals, at any and every stage of career development. Even seasoned hematologists, internists, and hospitalists will find something new and informative on practically every page. The book's approachable, engaging style will also appeal to science-minded readers who will appreciate being awakened to the workings of hemoglobin, a miraculous molecule.

The book delves into the multifaceted world of migraine pain, offering a profound understanding of its underlying pathophysiology and presenting established treatment strategies for its effective management. It discusses the intricate world of migraine pain, offering valuable insights into its diverse aspects. Starting with an exploration of migraine's epidemiology and etiology and the complex factors contributing to this debilitating headache disorder. This book explores the significance of lifestyle changes and offers practical strategies for incorporation. Furthermore, the impact of diet and nutrients on migraine management is extensively covered, shedding light on their role in alleviating symptoms. This book serves as a comprehensive guide, blending scientific insights with practical approaches, making it an indispensable resource for healthcare professionals, researchers, and individuals seeking a deeper understanding of migraine pain. By addressing both established practices and cutting-edge advancements, it bridges the gap between knowledge and effective management, offering a holistic perspective on this challenging condition.

This volume includes nine chapters that detail advances in health and disease. In chapter one the authors review proteins and transcription factors involved in the process of EMT and analyze the potential of proved or non-proved phytodrug to inhibit resistance to conventional therapies and /or metastasis, emphasizing their specificity. Chapter two provides an overview of the knowledge gained so far concerning the role of different members of phosphodiesterases subfamilies under physiological, as well as pathological conditions. In chapter three the authors discuss the involvement of IL-9 and Th9 cells in various cancers, highlighting their role in cancer immunity. The authors in chapter four identifiy the prospects for using drugs with anticonvulsant action that primarily restricts neuronal excitation via modulation of the brain's functional neurovascular unit. In chapter five, the authors propose a novel method for calculating (possibly multiple) univariate scores per individual to identify disease subtypes using multiple brain images (multi-modal brain images) obtained from multiple measurement or processing methods. Chapter six provides a detailed introduction of cognitive rehabilitation, presents the history and types of theories in this field, and then reviews studies that have recently used cognitive rehabilitation methods in different samples of patients and types of disorders and have reported the efficacy of these intervention methods. The causes, molecular mechanisms, and the diagnosis and treatment of prostate benign hyperplasia is examined in chapter seven. In chapter eight a model of a virus attacking a cell is proposed from the standpoint of sorption processes of cytoplasmic nucleotides, as a resource of both genomes. Using the method of gravitational non-invasive mass spectroscopy (GMS), the conformational state and the mechanism of action of domains in the myosin heads of the eye muscles of probants of different ages are studied in chapter nine.

Wenn aufgrund einer Darmerkrankung ein künstlicher Darmausgang angelegt werden muss, stellen sich viele Fragen:Warum ist ein Stoma erforderlich, und wie funktioniert es?Wie gehe ich mit dem Stoma im Alltag um, und wie muss es gepflegt werden?Welche Probleme können im Zusammenhang mit dem Stoma auftreten?An wen kann ich mich wenden, wenn ich Unterstützung benötige?Und letztlich: kann das Stoma auch wieder beseitigt werden?Alle diese Fragen sind detailliert und gut verständlich von Fachleuten aus den verschiedenen Berufsgruppen, die in die Betreuung von Patientinnen und Patienten mit Stoma eingebunden sind, beantwortet.

This book covers advances in treatment of hair loss and hair diseases over the past 50 years. It includes the changes in the methods used in surgical hair restoration from plugs to individual hairs, from manual punches to robotic surgery. It covers the first FDA approved treatment for hair loss - Minoxidil - and the first approved medication to prevent baldness - Propecia. It will also cover newer, non-prescription treatments such as Low Level Laser Light, Platelet Rich Plasma, and Photomodulation. Other conditions covered will include alopecia areata, frontal fibrosing alopecia (a new disease to dermatology), as well as chapters on hair follicle research and cloning of hairs. Hair Loss: Advances and Treatments will be a must-have resource for dermatologists as well as other physicians who deal with hair loss and hair loss treatment.

Die Mikroneuroanatomie ist für das Verständnis des Gehirns unerlässlich. Die Vermittlung von neuroanatomischen Kenntnissen ist in vielen Fällen eine schwierige Aufgabe, was jedoch vor allem an denjenigen liegt, die dieses Wissen in Kursen, Vorlesungen oder in Büchern vermitteln sollen.In Wirklichkeit ist die Neuroanatomie einfach und muss als Hilfsmittel für die Annäherung an die verschiedenen Bereiche des Gehirns und nicht als Hindernis verstanden werden. Die einzige Möglichkeit, dieses Problem zu überwinden, besteht darin, die Neuroanatomie mit verschiedenen Krankheitstypen in Beziehung zu setzen (arteriovenöse Fehlbildungen, Aneurysmen, Tumore, Kavernome, Hydrocephalus usw.).Dieses Buch bietet einen neuen Ansatz für die Beziehung zwischen Mikroneuroanatomie und Hirnerkrankungen. Jedes Kapitel befasst sich mit einer bestimmten neuroanatomischen Region und setzt alle wichtigen neuroanatomischen Aspekte mit den Krankheiten, die diese Region betreffen, in Beziehung. Außerdem bietet jedes Kapitel detaillierte Einblicke in die sichere Durchführung von hirnchirurgischen Eingriffen in der jeweiligen Region.

This book covers various aspects of the future of medicine, focusing on innovations in diagnostics, patient care, and drug discovery. With an increasing understanding of the structure and function of the human genome, along with continually improving laboratory and computational technologies, genomics has become progressively integrated into the core of biomedical research, medical practice, and the community. We are at the beginning of a fundamental shift in medicine, moving away from treating disease symptoms and toward curing diseases at their molecular causes. Artificial intelligence will aid in developing individually tailored therapies, gathering and exchanging big data, and advancing telemedicine to bring critical medical expertise to more patients worldwide. The future of medical artificial intelligence looks very promising, demonstrating that artificial intelligence can improve healthcare delivery. The twentieth century saw rapid advancements in disease prevention, including vaccine development and risk-factor prediction and intervention, nearly doubling global life expectancy. Healthcare has already entered the next phase of remarkable progress two decades into the twenty-first century. This book will be useful for health professionals interested in the future of medicine.

This book describes recent progress in the mechanistic studies and applications of surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS). In this book, various novel techniques in SERS and TERS such as UV resonance TERS, electrochemical TERS, and three-dimensional SERS imaging are outlined. A number of new applications of SERS and TERS such as those to photonics, nanotechnology, microfluidics, and medical diagnosis along with future perspectives are also discussed. Finally, the applications of new data analysis, models, and machine learning in SERS and TERS studies are reviewed. The novelty of this book is the forming of a new bridge between the theory and applications. Also, the importance of chemical mechanism and that of semiconductor-enhanced Raman scattering is emphasized. The main audiences are researchers in academia, research institutes, companies, and graduate students looking for a comprehensive book on the latest studies of SERS and TERS.

This book offers a comprehensive summary of the current and historical trends in physician workforce diversity by residency training specialty and demographic identity group. This book serves as a one-stop source for physician workforce diversity from the perspective of training specialties, summarizing trends over time, historical barriers, and specialty specific interventions and solutions. Chapters provide a necessary foundational resource for medical educators seeking to enhance diversity, equity, and inclusion (DEI) in their programs and programming. It similarly supports health system and organizational leaders in understanding the current and historical landscape of DEI across medical specialties and demographic groups to inform their interventions and initiatives in an evidence-based manner. The book is divided into two sections: training specialties and demographic identity groups. In the first section, DEI within several of the largest medical residency training specialties is explored. In the second section, the representation trends of various demographic identity groups, including women and individuals from racial and ethnic minority groups, and deaf and disabled individuals, are discussed, as well as barriers and solutions to improving representation, equity, and inclusion. Each chapter will follow the same format: Relevant specialty- or demographic-specific literature is reviewed, discussing the rationale for workforce diversity and inclusion in that specialty or demographic identity group. Current data by race, ethnicity, sex, and other available demographics is discussed for various trainee and practicing physician categories across the training and professional continuum, such as practicing physicians, academic faculty, graduate medical education residents and fellows, residency applicants, and medical school graduates. Historical demographic trends are assessed over time. This is followed by a thorough discussion of specialty or demographic-specific strengths and weaknesses to DEI and related barriers, impediments, and interventions and solutions. This is an ideal guide for medical educators, department chairs in academia and private/community practice, health system leaders, healthcare organization board members and executive leaders, diversity thought leaders, search committees, and medical students and trainees, especially during their specialty selection process.

Dieses Buch ist eine kompakte klinische Einführung in die Lyme-Borreliose für Ärzte aller Fachrichtungen, die Patienten mit Verdacht auf B. burgdorferi-Infektion betreuen, sei es im Krankenhaus oder in der Allgemeinpraxis. Das Buch bietet viele praxisorientierte Informationen zu Symptomatik, Diagnose, Behandlung und Prophylaxe mit besonderem Schwerpunkt auf der Situation in Europa. Gleichzeitig beschreibt es den aktuellen wissenschaftlichen Kenntnisstand so detailliert, wie es für das Verständnis der pathogenetischen Zusammenhänge und deren Relevanz für die medizinische Versorgung erforderlich ist. Die Autoren sind Mitglieder einer interdisziplinären Expertengruppe von Epidemiologen, Biologen, Mikrobiologen und Klinikern, die seit vielen Jahren auf dem Gebiet der zeckenübertragenen Krankheiten tätig sind. Die persönliche Erfahrung jedes einzelnen Autors, die er durch die tägliche Arbeit mit Patienten in Spezialkliniken oder durch die Konfrontation mit komplizierten Fragen der Grundlagenforschung, Epidemiologie und Labordiagnostik der Lyme-Borreliose gesammelt hat, stellt eine wichtige Stütze des Buches dar. Aus dem Blickwinkel des klinischen Managements und der praktischen Problemlösung geschrieben, wird diese aktuelle Monographie den Kliniker bei der Bewältigung diagnostischer Herausforderungen und der angemessenen medizinischen Versorgung von Patienten mit Lyme-Borreliose unterstützen.

Sex/gender-specific medicine (SGM) is defined as the practice of medicine based on the understanding that biology and social roles are important in men and women for prevention, screening, diagnosis, and treatment. Current research demonstrates differences in disease incidence, symptomatology, morbidity, and mortality depending on sex and gender. Sex/gender-specific medicine is a fundamental aspect of tailored therapy and precision medicine. Therefore, the variables must be considered in medical education and practice as well as in research models ranging from human participants, animals and cells. This concept could be applied in the whole clinical areas from Neuroscience, Psychiatry, Gastroenterology, Cardiology, and Rehabilitation, etc. Nowadays estrogen is known to play a key role in the prevention of colon cancer and in the resistant progression of liver cirrhosis and hepatocellular carcinoma, especially in women. This book covers the sex/gender-specific medicine in the whole clinical areas in the adults as well as in the pediatrics. In addition, research results of basic science are also introduced in the colon cancer and Alzheimer's disease.

This book explores key aspects of scientific reasoning, clinical methodology, and evidence-based practice, using quotes from the lectures of Jean-Martin Charcot (1825–1893) as a starting point for discussion and in-depth analysis. Charcot is a towering figure in the history of medicine, regarded as the father of modern neurology. The lectures he delivered at the Salpêtrière Hospital in Paris, where he examined patients with various disorders, remain an invaluable source of insight into his reasoning, clinical acumen, and methodology. The book aims to bridge the enduring legacy of the past with recent advances in epistemology and clinical methodology. It covers a variety of relevant topics, including inductive and deductive reasoning, logical fallacies, the importance of history-taking, the Bayesian approach to diagnosis, principles of evidence-based practice, critical appraisal of different study types, and the necessity of a skeptical attitude toward tradition and authority. Readers will gain crucial insights into scientific reasoning and clinical methodology from a fresh and potentially enlightening perspective. This could enhance clinical activities and stimulate thoughtful and critical reflections on everyday clinical practice.

The foot and ankle are among the most complicated anatomical regions of the human body, making their examination challenging. The perfect equilibrium between bones, tendons, ligaments, and other anatomical structures can be disturbed by pathological processes leading to complex disorders. The path to definitive diagnosis passes through a comprehensive clinical and radiological examination. However, the sources focusing on examining the foot and ankle pathologies are limited. Hence, this book aims to cover all aspects of clinical and radiological examination of the foot and ankle, including basics, general approach, and a closer look at the different foot and ankle pathologies. It will include the most up-to-date diagnostic methods, special tests, and radiological evaluations and give clues about the various situations that should be considered before going into surgery. With a broad range of clinical and radiological images, the path to diagnosis gets simpler! Chapters provide a systematic approach to evaluating various foot and ankle problems such as instabilities, tendinopathies, deformities, trauma, neuropathies, cartilage disorders, impingement, heel pain, etc. Moreover, it includes a chapter emphasizing the emerging technologies used for more precise clinical evaluation.This book will aid foot & ankle surgeons, podiatrists, and general orthopedic surgeons in understanding clinical and radiological examination for improved diagnosis, as well as fellows, residents, and medical students interested in foot and ankle pathologies.

Fractures of the scapula are usually associated with high-energy trauma and its management has deeply changed in the last decade. The unfavorable scapular anatomy, combined with the complexity of the approaches for fracture fixation, make the treatment challenging, even for experienced surgeons. Furthermore, the literature is controversial regarding surgical indications and rationale for treatment. This book is designed to address and discuss critical aspects of decision making for the management of scapular fractures, including anatomy, epidemiology, surgical indications, rehabilitation, treatment, and outcomes. It also presents several challenging cases with adequate preoperative planning, emphasizing the different approaches, fixation strategies, soft tissue handling, and postoperative care. Floating shoulder and the association between scapular fractures and clavicle fractures are also addressed, as well as a hot topic and emerging issue: the periprosthetic scapular fracture following reverse shoulder arthroplasty. The approaches and fixation strategies will be the main points of the book and richly illustrated by images. Fractures of the Scapula – Current Concepts is an indispensable reference to shoulder surgeons, general orthopaedic surgeons, orthopaedic trauma surgeons, thoracic surgeons, orthopaedic fellows and residents, medical students, and physical therapists who are eager to deepen their knowledge in the management of the challenging scapular fractures. •the Editors modified the proposal based on the reviewer's feedback.

This volume includes eight chapters that detail advances in health and disease. Chapter one highlights recent advances in minimally invasive VLNT with a particular focus on VOLT. Chapter two gives a comprehensive review of structure and function of perforin, its association with diverse human diseases including SLE-MAS, and associated CD8+ T and NK cell dysfunction in such conditions. The authors of chapter three use the method of gravitational mass spectroscopy (GMS) to study the state of the genomes of the Influenza A and HSV-1 viruses in the organisms of two probants of the same family. Chapter four provides a comprehensive overview of the recent developments in RSM, emphasizing its utility in drug formulation, design, and optimization. The authors of chapter five explore the detrimental effects of depleted uranium (DU) on the environment, as well as the many radiological and biological implications. Chapter six investigates the mechanism of the second stage of treatment of prostate hyperplasia using non-invasive biophysics and biochemistry (destruction of adenoma). Chapter seven describes a new approach for processing surgically retrieved specimens using differential centrifugation. Chapter eight presents gravitational mass spectroscopy (GMS) data on the molecular structure in the local function of the right hemisphere of the brain (LFP-1) responsible for controlling the prostate.

This book was written by Kenneth M. Heilman, a neurologist with a long and productive clinical and academic career, including being a researcher and teacher. Based on his experiences and achievements, as well as his frustrations and failures, he examines the challenges of healthcare, including what problems exist and how these problems may be improved. Each chapter in this book focuses on integral areas of medicine, including research, creativity, career development, patient-physician relationship, wellness, medications, social considerations such as race, and medicine's future. Changes in Medicine offers a unique view to the rapidly evolving field of neurology and practicing medicine.

This edited volume describes key domains of the emerging research literature linking exercise and mental health. The volume is divided into three sections. The first section provides an overview of foundational knowledge regarding basic processes of exercise, including neurocircuitry, neurotransmitter, and immunology systems. The second section describes emerging research on the acute impact of exercise on affect, mood, and cognition. The third section explores the role of exercise in the etiology and treatment of related mental and physical health disorders, including depression, PTSD, eating disorders, and autoimmune disorders. Collectively, this volume provides readers with foundational knowledge of what exercise is, the basic brain, behavioral and cognitive processes engaged by exercise, and a role of exercise in developing and treating mental health disorders.

The book delves into the development and therapeutic potential of Sodium-glucose Cotransporter-2 (SGLT2) inhibitors for the treatment of diabetes and cardiovascular diseases. It explores their mechanism of action, cardiovascular benefits, and role in primary and secondary protection from renal and cardiovascular diseases. The book also highlights their emerging opportunities in the management of myocardial infarction, diabetic cardiomyopathy, and congestive heart failure. It provides a comprehensive review of preclinical and clinical information on the cardiovascular advantages of SGLT2 inhibitors. Additionally, the book explores selective drugs and their effects on cardiovascular events, mortality, and safety outcomes in individuals with type 2 diabetes. The book is a valuable resource for researchers, healthcare professionals, and individuals interested in the field of SGLT2 inhibitors and their impact on diabetes and cardiovascular health.

Aimed at healthcare students: medical, nursing, and allied professionals, the textbook covers a broad range of topics in Global Health as investigated and summarized by Cardiff University medical students completing a short course in Global Health. Global Health is an increasingly important aspect of the undergraduate medical curriculum but is rarely formally taught at undergraduate level. It focuses upon health in Low- and Middle-Income Countries (LMIC). Chapters include: What is Global Health; changing demographics and disease burden; Humanitarian medicine, Aid; health in conflict; Sexual Reproductive Health; Gender Based Violence; child health; disability; cancer care; palliative care; infectious disease; neglected tropical disease; the climate crisis and sustainable healthcare, amongst others.

This book overviews ongoing and upcoming clinical applications of basic immunology. Recent advances in our knowledge of immunology coupled with new technologies have aided in the development of efficient cancer immunotherapy, as well as the control of emerging microorganisms such as SARS-CoV-2. However, knowledge of basic immunology has not been fully utilized even after the discoveries of immune checkpoint inhibition for cancer immunotherapy and the development of mRNA vaccination against SARS-CoV-2. There is still room for improving the clinical application of basic immunology. The book summarizes the achievements in clinical applications of basic immunology and highlights what can be further extended to make immunology a more practical human science. Basic immunology and its clinical applications are two wheels of the same cart in the immunology field, which aids in the development of more efficient cancer immunotherapy and rapid control of infectious diseases against microorganisms, including new viruses and classical toxoplasmosis. The exploration of ongoing and upcoming applications of basic immunology in this book makes it a useful resource for immunologists, physicians, molecular and genome biologists, bioinformaticians, and students in these fields.

In diesem Praxisbuch wird der Bedeutsamkeit der Problem- und Zielanalyse und Zielformulierung in der Psychotherapie als Fundament einer Behandlung dadurch Rechnung getragen, dass sich alle Fallbeispiele auf diese Bereiche beziehen. Als passionierte Impact-Technik-Anwenderin beschreibt die Autorin jede eingesetzte Übung von der Idee bis zur Durchführung. Impact-Techniken sind multisensorische Elemente aus verschiedenen Therapierichtungen und dadurch kraftvolle und nachhaltige Arbeitsmethoden. Sie sind therapieschulenübergreifend, unabhängig vom Alter und von Beschwerdebildern einsetzbar. Attraktiv an diesen Techniken sind die Einfachheit der Durchführung und dass alle in der Umgebung zur Verfügung stehenden Gegenstände als Arbeitsmittel benutzt werden können. Durch die zahlreichen Anwendungsbeispiele von Impact-Techniken in diesem Buch soll der Transfer vom Gelesenen in den eigenen Behandlungsalltag unterstützt werden. Aus dem Inhalt: Trotz Bemühungen erreicht der Patient sein Ziel lange nicht, der Therapieverlauf stagniert trotz vorhandener hilfreicher Strategien. Verstrickungen sichtbar machen und auflösen, unklare Therapieziele konkretisieren, Therapiemotivation klären. Über die Autorin: Dipl.-Psych. Katrin Vader ist niedergelassene Psychotherapeutin für Erwachsene (Schwerpunkt Verhaltenstherapie) in eigener Praxis in Jena. Lehrpraxis, Supervisorin, Selbsterfahrungsleiterin und Dozentin für verschiedene psychotherapeutische Ausbildungsinstitute in Deutschland.

Medizinische Zeichnungen gelten gemeinhin als „objektive“ Abbildungen des menschlichen Körpers bzw. seiner Krankheiten. Die Beiträge des vorliegenden Buches zeigen, dass der medizinische Blick und somit auch die Abbildungspraxis einem historischen Wandel unterworfen ist. Ausgehend von Wandbildern, Zeichnungen, Lithografien, Glasplattendias, Fotografien aber auch Filmen zeigen Expert•innen, welches Wissen dem jeweiligen medizinischen Blick und den Darstellungsweisen implizit war.Dieses Nachschlagewerk stellt auch Wissenschaftsgeschichte dar und geht auf ethische Gesichtspunkte von Abbildungen ein, die es neben den offensichtlich gezeigten und oft plakativen Inhalten aufzuzeigen gilt.Das Buch erkundet die Verwendung und den Herstellungsprozess von medizinischen Abbildungen und dokumentiert zugleich die Durchführung der Lehre und die jeweilig aktuelle medizinische Forschung.

Every practicing physician, surgeon, advanced practice provider, and allied health professional interacts regularly with peer-reviewed literature: either while creating it, or consuming it. Despite the countless hours over many years spent in formal clinical training, many clinicians and clinician-authors lack advanced training or a working nuanced knowledge of research methodology and study design. Institutions have responded to this gap by reinforcing their ranks with statistical and methodological support in the form of data analysts, epidemiologists, and biostatisticians. However, clinicians are often unable to “talk the methodological talk” to guide them. This ultimately results in a stark disconnect between clinically relevant aspects of research and appropriate study design. Existing research methodology texts are largely written by statisticians, epidemiologists, and other academic public health experts. These are not easily digestible by practicing clinicians who need practical knowledge of this content to design their own research or enhance their understanding of the medical literature. Furthermore, these texts are often too detailed or “in the weeds” with regard to mathematics and statistical mechanics. Practical knowledge is not centrally located; rather, it is spread out among multiple books, articles, and other sources. This book is a concise, accessible, and practical guide for clinicians to read and reference when designing and reviewing clinical research. It is designed to be a standalone text, written “by a clinician, for clinicians” by a practicing clinical research expert who has had advanced formal training in research methodology, biostatistics, and epidemiology. Topics covered include descriptive and comparative statistics, power and sample size calculations, diagnostic tests, bias, and study design. In each chapter, consideration is given to study mechanics, advantages and disadvantages of each design, and illustrative analytical reviews of existing literature.

This is a book about medical communication. Communication is a skill, as such it is learnable and can be refined. Between what we learn in college and clinical practice there is a gap regarding communication with patients and their families that many health professionals want to fill. Thus, the goal of this book is to encourage readers to develop their communication skills in patient care. Chapters cover the possible therapeutic origin of the human word, the placebo effect of the medical word, the distinction between information and communication, and the importance of empathy while communicating with patients. An overview of the medical words throughout history up to our current practice is presented. In addition, the content helps to develop a strategy for nonverbal communication and to analyse the impact of empathy on communication and patient satisfaction. Current topics such as special needs for LGBTQ patient care, telehealth and virtual communication are also featured in this book. Knowing how to communicate is healthy not only for the patient but also for the doctor. Therefore, the prevention of medical burnout through adequate communication, both in routine practice, and with patients with special needs, as well as in telemedicine is also discussed. Finally, the author addresses a personal and non-transferable task: each individual must build their own toolbox for communication - the stories, the anecdotes, the metaphors, the silences with which each of the readers will use to communicate with their patients. The aim of this book is to bridge a gap between the graduate and postgraduate training for dealing with information and problems in communicating during clinical practice. Since it is never too late to acquire or improve our communication skills, this work will be a useful and valuable resource for any health professional interested in the subject.

Medical errors can have serious consequences, often resulting in harm to patients or even death. In the last decades the issue of the 2nd victim was raised, emphasizing the impact of being involved in an adverse event on the ability of caregivers to provide high quality and safe treatment. In 1999, the American Institute of Medicine (IOM) declared that rather than assigning blame for these errors, professional investigations should be carried out to identify what caused them and prevent similar events from reoccurring in the future focusing on systemic factors. It is estimated that in the US alone, there are between 250,000 to 400,000 preventable deaths annually due to medical errors, costing over 15 billion dollars per year. In response to this challenging issue, a team of medical professionals has created a comprehensive textbook on the subject of safety and risk management in medicine. This book covers a range of topics, including basic principles and concepts, the scope of iatrogenic harm, the development of risk management in medicine, and the organizational safety culture. Emphasis is placed on the human and organizational factors that contribute to medical errors, as well as practical methods and tools for coping effectively with this phenomenon. The book is based on extensive practical experience in promoting patient safety in a variety of medical organizations. In addition, the book includes a large chapter on risk management during epidemics, which has become increasingly relevant in the wake of the COVID-19 pandemic. This textbook is a must-read for anyone involved in patient care, including doctors, nurses, managers, pharmacists, psychologists, occupational therapists, physiotherapists and students in all medical professions. By promoting a culture of safety and risk management, we can work towards reducing the number of preventable medical errors and improving patient outcomes.

This book provides a novel method to teach eponymically named physical signs of the alimentary tract and intrabdominal organs. The focus is on the historical aspect of the named signs, how to perform the sign described by the author, and the pathophysiologic mechanisms involved in eliciting a positive test. The goal is to guide the reader to appreciate how these bedside signs provide a more profound understanding of the mechanism of disease. By doing so, they become more than simply rote memorization but an appreciation of how a direct hands-on assessment involving observing, engaging, listening, and touching the patient assists in diagnosis. Hence, these techniques provided the additional benefit of better connecting the practitioner to the patients and maintaining the art of medicine, which is rapidly losing its foothold within the medical community. This book will serve as a teaching tool for learners, teachers, and practicing physicians to preserve the artof the physical examination using a form of a case-based teaching and learning style approach. Illustrations throughout the text provide a visual representation of how to perform the sign. The authors believe this method of teaching and learning is more meaningful to the student in that they will be able to associate the name with the person's historical features, the sign, and its pathophysiologic mechanism(s). Gastrointestinal Eponymic Signs is a must-have resource for medical students, residents, fellows, teaching faculty, and any practicing physician seeking to understand how physical examination signs assist in diagnosis.

En este libro se incluyen referencias básicas de conceptos relativos a la Seguridad y Salud en el Trabajo, la prevención de riesgos laborales y la tipificación de los accidentes de trabajo y enfermedades profesionales. En ocasiones el nexo entre ciertas actuaciones vinculadas a la Salud Ambiental y Laboral determina la necesidad de presentar las articulaciones existentes entre las mismas, como complementarias una de la otra. Mediante la lectura minuciosa del texto será posible identificar aquellos factores esenciales que nos ayudan a comprender la salud en relación con el Medio Ambiente, descubriendo la concepción histórica y situación actual dentro de los diferentes enfoques que afectan a la salud. Este es por tanto un manual que presenta una visión bajo una perspectiva general, incluyendo: la educación, el marco legal, microbiología, toxicología, higiene y otros aspectos ambientales con relevancia para la salud humana.

„Gestresst!“ – „Keine Zeit!“ – „Ich weiß nicht, wo mir der Kopf steht!“ Stress kennt fast jeder, und viele leiden unter den negativen Folgen von Dauerstress. Was also tun? Dieses Buch zeigt vielfältige Handlungsmöglichkeiten auf und macht Mut für den eigenen Weg zu einem gelassenen und gesunden Umgang mit Stressbelastungen in Beruf und Alltag. Es ist geschrieben für Stressgeplagte zur Selbsthilfe und als verständliche Begleitlektüre bei Stressbewältigungskursen oder im Rahmen einer Beratung, für Personalverantwortliche und Führungskräfte in Wirtschaft und Verwaltung, auch für beratend und therapeutisch Tätige, die stressbelastete Personen unterstützen, und für alle, die ihre persönliche Stresskompetenz weiterentwickeln wollen. Aus dem Inhalt: Instrumentelle Stresskompetenz: den Alltag stressfreier gestalten, Anforderungen aktiv begegnen – Mentale Stresskompetenz: förderliche Einstellungen und Bewertungen entwickeln – Regenerative Stresskompetenz: Ausgleich schaffen, entspannen und erholen – Mit Checklisten, erprobten Übungen und praktischen Tipps. Der Autor: Prof. Dr. Gert Kaluza ist psychologischer Psychotherapeut und als Trainer, Coach und Autor im Bereich der individuellen und betrieblichen Gesundheitsförderung tätig. Nach 20jähriger Tätigkeit an verschiedenen Universitäten gründete er 2002 ein eigenes Fortbildungs- und Trainingsinstitut, das GKM-Institut für Gesundheitspsychologie, das er bis 2022 selbst leitete.

Adipositas oder Fettleibigkeit ist eine extreme Form des Übergewichts mit einem hohen Risiko für Folgeerkrankungen. Der unterhaltsam und leicht verständlich geschriebene Ratgeber zeigt mögliche Auswege aus dieser Krankheit und will somit zu einer Verbesserung der Lebensqualität von Adipösen beitragen. Der Autor, ein erfahrener Chirurg, war Leiter des Adipositas-Centrums Münster und erklärt einfühlsam die Hintergründe des Krankheitsbilds und die Grenzen der nicht-operativen Behandlungsmöglichkeiten. Im Mittelpunkt einer erfolgreichen Therapie steht ein ganzheitliches Konzept, in dem die Adipositas-Chirurgie wie ein Mosaikstein in ein komplexes Behandlungsregime eingebettet ist.Es gibt eben doch Lösungen jenseits von Frühlingsdiät und Jojo-Falle! Nicht durch eine neue Diät als letztem Schrei oder andere Zaubertricks, sondern mittels professioneller Diagnostik, Beratung und einer operativen Maßnahme können Übergewichtige wieder zu einem leichteren Leben zurückkehren.Durch umfangreiche Informationen will der Autor seinen Leser•innen die Angst vor einer Operation nehmen und Selbsthilfegruppen bei ihrer Aufklärungsarbeit unterstützen. Denn: Für die meisten Betroffenen ist die Operation nach aktuellsten wissenschaftliche Erkenntnissen keine „Ultima Ratio“, sondern der einzig erfolgversprechende Weg.Das Buch ermutigt Betroffene, Verantwortung für ihre Situation zu übernehmen, indem sie Unterstützung bekommen und selbst aktiv werden. Es ist aber auch für all jene geschrieben, die verstehen wollen, warum sich in unserer Gesellschaft die Adipositas immer weiter verbreitet und warum Diäten in der Behandlung ungeeignet sind.

Plastination is currently considered one of the most innovative forms of conservation of complete bodies, sections and organs, both human and animal, for use in undergraduate and postgraduate teaching, as well as morphological research. In this sense, to develop the various plastination techniques, specific equipment and specialized training of academics are required, who have the ability to carry out the diversity of protocols that exist, depending on the anatomical material to be preserved. The decomposition of organic matter is a vital process in nature, but it is also an impediment to morphological studies and research. This is particularly important in biological specimens that shrink considerably when exposed to normal atmospheric conditions. For this reason, it has always been a constantly pursued objective for anatomists. Plastination, in this regard, is a true alternative in the conservation of perishable biological tissues (complete bodies, complete organs such asbrains, livers, lungs, kidneys, hearts, muscles, joint preparations, cuts in sections of complete corpses) - or from isolated regions, etc.) reaching a dry and imperishable state through the use of different polymers and special plastics, ensuring that the organs, limbs and entire bodies do not lose their texture and apparently normal disposition. This original book describes in detail and in an updated way the plastination techniques for the conservation of human and animal biological material, demonstrating the applications in teaching and research of anatomy, morphological sciences and health sciences. The didactic chapters present the history and the fundamentals of plastination techniques (steps, equipment, supplies, material, temperature), as well as its clinical, surgical and research applications. The work also features biosafety issues and provides Ethical Considerations in Plastination. Advances in Plastination Techniques is intended for a cross-section of academics, technicians and advanced students from all areas of Health Sciences - including Physicians and Dentists - and Veterinary Sciences.

This volume contains eight chapters that detail advances in health and disease. Chapter One presents state-of-the-art research of Ovalbumin bioactive peptides (OVA-BAPs). Chapter Two focuses on providing a comprehensive overview of OVA in human nutrition and the food industry. Chapter Three elaborates on an approach to identify critical factors affecting the pharmacokinetics in rats of several formulations of acyclovir. Chapter Four provides a comprehensive review of the literature on the pathophysiology and current therapies of CP-induced hemorrhagic cystitis. Chapter Five focuses on endocrine immune-related adverse events (irAEs), including their pathogenesis, risk factors, diagnostic processes, clinical characteristics, and management. Chapter Six discusses the benefits of beetroot juice in resistance training. Chapter Seven presents the challenges and opportunities in postgraduate medical education. Lastly, Chapter Eight discusses biologically encapsulated nanoparticles, which are used for improving drug interaction to control and cure disease.

This book is the first volume to individually dissect and explore the reasons physicians are leaving medicine. It lays out potential solutions to many of the problems, which will result in a happier practicing physician. Chapters begin with the nature of the problem, and go through a physician's life cycle on the job, from medical school through post-grad and onwards. Chapters will also cover issues as a practicing physician and how to help alleviate these problems. The book ends with potential solutions to the issue of physician burnout. Physician Burnout: Why Doctors Are Leaving Medicine and How to Fix It is a must-have resource for practicing physicians, healthcare providers, and healthcare management. It is also a great resource for medical school students and those looking to get into the healthcare field.

This volume contains eleven chapters that detail advances in health and disease. Chapter One examines the role of demethylases in regulation, with an emphasis on existing and upcoming treatments that focus on this enzyme class. Chapter Two provides a multiparametric acoustic analysis of voice assessments. Chapter Three discusses the clinical applications and outcomes of splenectomies. Chapter Four analyzes the safety of laparotomy compared with the effectiveness of the procedure. Chapter Five proposes a multiple-factor regression mathematical model for predicting the diabetic foot ulcer development risk. Chapter Six presents the risk factors, indications, and management of relaparotomy after cesarean section delivery. Chapter Seven elaborates on the critical role of Sphingosine-1-phosphate (S1P) in wound healing cascades, with the goal of advancing the application of S1P-targeted therapeutic strategies in clinical treatment. Chapter Eight provides an overview of recent innovative developments, directions, and trends in the field of Paracetamol. Chapter Nine explains the function of paracetamol in treating dental pain and compares the risks and advantages of its use. Chapter Ten provides standard statistical rules that thoracic surgeons unfamiliar with statistical modeling analysis should follow. Finally, Chapter Eleven explains a study that applied next-generation sequencing and subsequent data analysis to investigate several food-borne non-typhoidal Salmonella strains.

55 Übungen für mehr Achtsamkeit im Berufsleben! Der Schlüssel für eine gute Betreuung im Gesundheitswesen ist die Wahrnehmung der Bedürfnisse des Gegenübers und von sich selbst. Besonders in Zeiten, in denen Zeitdruck und Stress alltäglich sind, ist es herausfordernd empathisch zu bleiben. Einfach im Alltag einzusetzen und zum Teamtraining geeignet. Die zweite Auflage ist komplett überarbeitet.

Die Belastungen steigen, die Kräfte schwinden: Ein Burnout droht. In diesem Ratgeber finden Sie praktische Anregungen, wie Sie wieder entspannen, genießen und frische Energie sammeln, anstatt erschöpft, gestresst und ausgebrannt To-do-Listen abzuarbeiten. Sie erfahren, was Sie selbst dazu beitragen können, um Burnout vorzubeugen oder zu lindern. Das alles gelingt mit dem jahrtausendealten Wissen des Qigong, der altchinesischen Philosophie und der Traditionellen Chinesischen Medizin, kurz TCM. Wie achten Sie liebevoll auf Ihre Grenzen? Wie lernen Sie neugierig aus Krisen? Wie bewältigen Sie Herausforderungen gelassen? Wie entdecken Sie Ihre Kraftquellen? Antworten darauf finden sich in den wichtigsten Weisheits-Lehren der TCM: dem 5-Elemente-Modell und dem Yin-Yang-Prinzip. Der Ratgeber erklärt das Burnout-Phasenmodell aus TCM-Sicht. Für jede Burnout-Phase finden Sie praktische Selbsthilfe-Tipps sowie einfache, aber wirkungsvolle Übungen für Körper, Geist und Seele. Mithilfe der klaren Anleitungen, Bilder und Videos erlernen Sie die kraftspendenden Atem-, Bewegungs- und Meditations-Übungen in wenigen Minuten. So können Sie endlich wieder genussvoll entspannen, tief durchatmen und jeden Tag freudig beginnen.

Bewegungsmangel gilt als wichtiger Risiko- und Realisationsfaktor für die Entwicklung von de facto fast allen chronischen Erkrankungen, wie z.B. Adipositas, Diabetes, Arteriosklerose, Arthrose oder auch neurodegenerativen Veränderungen. Zur Hauptursache - der physischen Inaktivität - kommt häufig noch eine kalorische Über- und Fehlernährung hinzu. Als gemeinsamer Ausgangspunkt für die Entstehung solcher Erkrankungen wird die Dekonditionierung gesehen, die bei längerem Bestehen über Funktionsstörungen zu Änderungen in der Struktur führt. Das Buch geht den Ursachen der Krankheitsentstehung auf den Grund und zeigt auf, welche physiologischen bzw. pathophysiologischen Vorgänge im Organismus ablaufen, wenn er längerfristig aufgrund eines sedentären Lebensstils nicht ausreichend bewegt wird. Es diskutiert dabei die wichtige Rolle der Muskulatur und des sensomotorischen Systems, die mit Querverbindungen zu fast allen Organen vernetzt sind. Neue Erkenntnisse zu den Reaktiven Sauerstoffspezies (ROS) und den Myokinen unterstreichen die Bedeutung einer ausreichenden körperlichen Aktivität zur Erhaltung der Gesundheit. Präventive und therapeutische Konsequenzen werden ständig abgeleitet! Das Buch richtet sich an alle Berufsgruppen, die degenerative Erkrankungen aufgrund mangelnder Bewegung behandeln und mehr über den physiologischen Zusammenhang der Krankheitsentstehung und die aktiven Konsequenzen erfahren möchten.

This book helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. The book covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms. This model has been successfully applied in various conditions, including inborn errors of metabolism, primary immunodeficiency, and endocrine disorders. However, integrating metabolomics with other omics datasets and clinical phenotypes requires careful study design, analytical tools, and data analysis and interpretation. This groundbreaking new book provides essential guidance for researchers, students, and professionals looking to leverage metabolomics in their own work, including biochemical and clinical geneticists, pharmacogenomics and pharmacometabolomics experts, pharmaceutics and diagnostic researchers, medical scientists, clinical dietitians, metabolic engineers, clinical chemists, and personalized medicine specialists.

This book aims not only to introduce fundamental biostatistics topics but to explain them through R-project (R-studio).'R'is perhaps the more used statistical software in the medical field. It is structured as a'scientific journey'and comes with a sham yet realistic dataset ready to be analysed. The dataset along with the R-script can be downloaded from GitHub, and each chapter has dedicated scripts that will enhance the understanding of R and biostatistics. Specifically designed for whoever works in the medical-academic environment, this practical guide will help the reader to become familiar with basic to advanced biostatistics topic (descriptive - analysis / regression etc.) and to gain solid knowledge of R.

This book provides a practical guide on the art and science of compassionate care in an era of healthcare crisis due to the COVID-19 pandemic that is inflicting long-lasting financial and psychosocial trauma on an unprecedented scale. A new approach to compassionate care is presented based on the overarching concepts of empathy, person and family centeredness, therapeutic relationship, kindness, gratitude, spirituality, communication skills, shared decision making, positive psychology, adversity-activated development, self-care, compassion fatigue, spirituality which are more than ever critical in successfully managing the pandemic adversity in front of us. This book draws on clinical experience, educational activities and evidence-based knowledge from academic physicians (primary, secondary and tertiary care), nurses,psychologists, health economists, healthcare managers, health policymakers, medical professionals students and patients. It provides skills and knowledge that can be implemented in daily clinical practice based on all levels of healthcare on a whole-person approach. An array of clinical cases, patient journeys, published evidence and practical experience is combined to deliver in a practical way unique guidance and advice. The target audience is all healthcare professionals, health policymakers, healthcare managers and patient associations. This approach of Compassionate Care is of great importance and can save lives and money in these unprecedented times of global healthcare care system challenges.

Nutrazeutika sind Hausmittel, die eigenständig aus Lebensmittel zubereitet werden und aufgrund ihrer Inhaltsstoffe eine wissenschaftlich nachgewiesene physiologische Wirkung auf die Gesundheit haben. Das Buch geht dem Phänomen ihrer Wirkung auf den Grund und beschreibt Anwendungs- und Zubereitungsmöglichkeiten dieser besonderen Lebensmitteln. Im allgemeinen Grundlagenteil wird das Wesen und der Nutzen von Nutrazeutika erklärt und es werden die unterschiedlichen Verarbeitungsmethoden vorgestellt. Im größten Abschnitt des Buches beschreibt die Autorin die einzelnen Lebensmittel und erklärt deren Wirkung und Wirkmechanismus. Beispiele dieser Lebensmittel sind alltägliche Kräuter, Gewürze, Obst und Gemüse, wie sie in jedem Haushalt eingesetzt werden, z.B. Kamille und Anis sowie Äpfel und Zwiebel. Die abschließenden Kapitel thematisieren die Anwendung in der Gesundheitsförderung sowie in der Therapie bei verschiedenen häufigen Indikationen.Das Buch richtet sich an alle Personen, die in der Gesundheitsberatung tätig sind, wie etwa Diätologen, Ernährungswissenschafter, Ernährungsmediziner sowie an alle an dem Thema Interessierten.

​Der ulnokarpale Schmerz entspringt aus einer funktionell äußerst wichtigen Region am Handgelenk. Aufgrund der Komplexität der Strukturen ist einerseits die Kenntnis der Anatomie und andererseits das Verständnis der Biomechanik dieser Gelenkregion essentiell für eine zielgerichtete Untersuchung und Diagnostik. Nach Darlegung dieser Grundlagen werden die häufigsten Differentialdiagnosen, von traumatisch bedingten Läsionen über degenerative Alterationen bis zu angeborene Pathologien vorgestellt und die möglichen konservativen bzw. operativen Therapiemöglichkeiten präsentiert.

This unique book is a major contribution to the literature on persuasion in communication, and on doctor-patient communication, in particular. Written by a physician-scientist with deep experience on the topic, the book offers a comprehensive analysis of what makes an argument in medicine persuasive, outlining the characteristics of an argument that causes people to accept that the conclusion(s) of an argument are true. Although the book focuses on medical arguments in particular, the general approach offered by the author is appropriate for any informal argument. The central emphasis is that although sound logical construction and true premises are required to establish the logical truth of a conclusion, this is insufficient for persuasion to occur. Although formal logic can exist independent of human reception, real-world arguments must have both an arguer (the individual constructing the argument) and an audience (individuals listening and evaluating the argument).Whether the audience is capable of changing their world view is as important as the logical construction of the argument, maintains the author. To illustrate all points, a plethora of examples in medical research and in diagnosis and treatment decisions are presented. Medical Persuasion: Understanding the Impact on Medical Argumentation is a unique contribution to the clinical literature and will be of immense interest to medical practitioners, researchers, and philosophers as a way of gaining insights into constructing arguments for their peers and patients. In addition, medical trainees will gain important insights in the production of medical knowledge and medical practices, and even students in the social sciences and humanities will find the work valuable as a conduit to gaining insight into the reception of an argument.

This book is comprised of twelve selected chapters on advances in health and disease. Chapter one covers applications of nano-formulations in drug delivery for skin disease treatments. Chapter Two examines the use of dipeptidyl peptidase-4 inhibitors in the clinical management of diabetes mellitus. Chapter Three reviews the role of sex hormones in asthma therapy. Chapter Four looks at therapies for critically ill COVID-19 patients. Chapter Five examines resistance plasmids; the key to the adaptation of pathogenic microorganisms in hospital environments. Chapter Six shows how oleic acid prevents oxidative stress by inhibiting metabolic pathways in clinical disorders. Chapter Seven reviews the question of post-COVID-19 reactive arthritis, and whether it is a myth or reality. Chapter Eight examines the diagnosis and treatment of dermoid ovarian cysts in children and adolescents. Chapter Nine reviews the beneficial effects of testosterone replacement therapy in older individuals. Chapter Ten covers the state of the art in difficult to treat rheumatoid arthritis. Chapter Eleven provides therapeutic updates on the condition of juvenile psoriatic arthritis. Chapter Twelve examines the underdiagnosed pathology of sinus tarsi syndrome.

Neuroanatomy is considered one of the most complex subjects in the field of anatomy. The reliable literature for students is limited to classical anatomical books, many of them re-editions of publications from the previous century, with black-and-white illustrations or computer-generated images. In this sense, the literature lacks a neuroanatomical atlas depicting the brain's surface anatomy and intrinsic anatomy with actual anatomical preparations. This illustrated and concise book is designed to fill the gap by providing high-quality photographs of actual anatomical preparations of the entire central nervous system. It is organized into eight chapters and presents high-definition photographs of thoroughly labeled anatomical preparations. The Cartographic Atlas of the Brain is intended to benefit medical students, residents and practitioners of Neurology, Neurosurgery, Neuroanatomy, Radiology, Neurobiology and other branches of the Neurosciences.

This captivating and clinically illuminating title presents the story of Dr. Michele Pato's personal experience with traumatic brain injury (TBI). With profound candor and humor, Dr. Pato chronicles her journey through the enormous physical, psychological, and emotional challenges encountered following her accident, treatment, and recovery. After years of rehabilitation and reflection, Pato relays her extraordinary story through an engrossing narrative that simultaneously pedagogically serves clinicians who treat TBI, while also offering important insights for patients and caregivers affected by TBI. Across 18 chapters, Pato addresses each physiological aspect of her treatment and recovery, including her battles with aphasia, neuromuscular and memory issues, tinnitus, and vertigo – to name just several of the setbacks she had to overcome. The book also details Pato's struggle to recover while negotiating a multitude of roles: maintaining a physician-researcher leadership position in academic medicine; managing relationships with her husband (a prominent physician-scientist as well), interacting with family and friends; and, most of all, overcoming the emotional frustrations associated with long-term physical recovery, such as relearning what were once innate motor and speech skills. A riveting account of personal injury that was met with extraordinary determination, patience, grace, and commitment to recovery, Nerve is a unique and valuable resource for clinicians, patients, caregivers and anyone else whose life has been touched by TBI

Der „Psychotherapie-Kompass“ bietet Orientierung und räumt mit falschen Vorstellungen über Psychotherapie und Psychotherapeuten auf. Schritt für Schritt vermitteln die erfahrenen Autoren dem Leser das notwendige Wissen zu psychischen Erkrankungen und Psychotherapie – von der Suche nach einem Therapieplatz, der Beantragung einer Therapie bis hin zur Rezidivprophylaxe. Das Buch berührt aber auch Themen wie Medikamente, stationäre psychiatrische Behandlung, Patientenrechte und vieles mehr. Die wichtigsten Musterformulare, Fragen und zahlreiche Webseiten-Verweise finden Sie ebenfalls in diesem Buch.

Die Labormedizin gilt nach Expertenmeinung als ausschlaggebend für rund 70% aller klinischen Entscheide, wird jedoch hinsichtlich ihrer Kosten und des Kosten-Nutzen-Verhältnisses labordiagnostischer Verfahren kritisch betrachtet. Mit diesem Buch veröffentlicht das Institut für Innovation & Evaluation im Gesundheitswesen eine von der schweizerischen Foederatio Analyticorum Medicinalium Helveticorum (FAMH) veranlassten Studie, um den gegenwärtig generierten und zukünftig zu erwartenden Nutzen von Laboranalysen aus der Perspektive von Patienten und Gesellschaft zu untersuchen. Dies ist ein Open-Access-Buch.

Dargestellt wird zunächst das Krankheitsbild des angeborenen Enteropeptidase-Mangels (Morbus Hadorn). Es zeichnet sich durch eine Gedeih- und Wachstumsstörung aus. Anschliessend wird die Genstrukturaufklärung mittels PCR und Sequenzierung beschrieben. Zuletzt wird auf Arbeiten von Kollegen eingegangen, die mittels dieser Methode erstmals Genmutationen bei betroffenen Patienten finden konnten.

This volume contains eight chapters that detail advances in health and disease. Chapter One provides a comprehensive review on the physicochemical, pharmacological and pharmacokinetic properties of paracetamol. Chapter Two reports about simulated microgravity, its effects on different organs of a healthy body, and its role in various types of diseases. Chapter Three discusses vitamin D and its relationship with nephrotoxic drugs. Chapter Four describes the epidemiology, pathogenesis, diagnosis (classification), and treatment of patients with hypertrophic pachymeningitis related to antineutrophil cytoplasmic antibody associated vasculitis. Chapter Five reviews the current scientific data regarding the genetic causes and novel genes involved in various abnormalities of sex development disorders. The authors in Chapter Six report their clinical experience with poly-methyl-methacrylate for a novel in vivo bone defect closure in various neurosurgical operations. Chapter Seven provides a detailed comparison of multiple studies that were conducted using a variety of approaches with the goal of preventing drug-drug interaction (DDI) responses, which are a form of adverse pharmaceutical reactions. Lastly, Chapter Eight covers upcoming nanotechnological methods and updates on liposomal research.

This book presents a collection of chapters on Covid-19 topics, with focus on the metabolomics and diagnosis. The chapters report on diagnostic tests for detection of SARC-CoV-2 virus and related proteins as well as post-Covid omics. This book covers Fourier-Transform Infrared spectroscopy and spectromicroscopy applied to Covid-19 studies and Carbon Nanomaterials as Covid-19 Electrochemical sensors. Moreover, the reader will find content on 3D printing for virus diagnosis, as well as organ-on-a-chip models for viral infection proteomics interaction.