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This book titled “From Pap Smear to HPV Vaccine − the Cervical Cancer Prevention Industry” by Dr. Sin Hang Lee provides a comprehensive analysis of how the HPV industry has invaded and eroded the women's health care system in the field of cervical cancer prevention. The analysis based on currently available science and public records provides the readers interested in cervical cytopathology, HPV molecular diagnostics and HPV vaccination with a clear understanding of issues and solutions to cervical cancer prevention. Pap smear screening in the United States was first implemented as an annual test in the late 1940s. Its widespread use for early detection of precancerous cells destined to proceed to invasive carcinoma for timely ablative treatment markedly reduced the morbidity and mortality rates of cervical cancer. No one should die of cervical cancer if every woman continued receiving proper annual Pap smear screening carried out by a team of cytology technologist, pathologist and gynecologist. However, this teamwork broke down when cytology samples were sent to geographically distant centralized commercial laboratories for screening. Under such business atmosphere, cytology screeners, pathologists and gynecologists hardly speak to one another to discuss any potential diagnostic problems. Overwhelming numbers of unnecessary colposcopic biopsies have been performed on essentially healthy women when “false positive” cytology reports are sent to their gynecologists. However, it is the false-negative results which draw public attention while stories about Pap smear litigation cases are circulated around social media sites when follow-up tests unexpectedly reveal an invasive cancer during the patient's annual screening. Further chaos was created after human papillomavirus (HPV) infections were discovered by Dr. Harald zur Hausen to be one of the most important risk factors for developing cervical cancer. A handful of opportunists successfully persuaded the Food and Drug Administration to regulate their HPV assays as cancer tests and anti-HPV vaccines as cancer vaccines so that they can market these products by tapping into the public's fear of cancer. Commercial HPV tests detect many reversible cytopathology changes with high viral loads per cell, but are not sensitive enough to detect high-grade precancerous cells with low viral loads per cell. Without performing DNA sequencing, none of these test kits can provide an accurate genotyping for follow-up of persistent HPV infections, a true cancer risk. This book points out there is no factual evidence that HPV vaccination has prevented a single case of cervical cancer. Using reversible precancerous histologic changes as surrogate endpoints in clinical trials to support the claim of efficacy of HPV vaccination in prevention of cervical cancer is flawed. Since the HPV vaccine Gardasil relies on using residual HPV L1 gene DNA fragments bound to aluminum salt as the toll-like receptor 9 agonist to boost innate immune response, high levels of pro-inflammatory cytokines are generated in the vaccinees. These pro-inflammatory cytokines may cause serious adverse events in genetically and physically predisposed individuals. Women consumers are advised to read this book before choosing the modalities for cervical ancer prevention to protect their own health and lives as well as those of their loved ones.

Human papillomavirus (HPV) infection transcends multiple fields of science and medicine. The management of HPV-related disease is demanding and often requires a persistent multimodal approach involving various medical disciplines. In this volume, experts present a comprehensive view of HPV research with an emphasis on clinical presentations, diagnosis, management and vaccine development. The state of the art in molecular biology is provided in addition to discussions on clinical morphology and the utility of dermatoscopy in identifying HPV disease. In a multidisciplinary approach to dermatological, plastic and reconstructive, gynecological, otolaryngological and colorectal management, different treatment strategies are highlighted. Finally, Dr. Neil Christensen discusses viral immunology, and the difficulties and successes in the development of an HPV vaccine. Bringing together basic science and clinical information on HPV, this book is an excellent resource and reference for all researchers and clinicians who encounter human papillomavirus-related disease.

Cervical Cancer screening, which includes the PAP test and HPV testing is an essential part of a woman's routine healthcare. This issue of the Ob/Gyn Clinics covers colposcopy and screening for women at all stages of life, along with the HPV vaccine, treatment options, and what is on the horizon regarding ever-changing screening methods.

Wie berät oder behandelt man eine Patientin mit Endometriose? Welche Vorteile hat die diagnostische Hysteroskopie gegenüber anderen Methoden? Wie behandle ich Blutungsstörungen? Sind OC-Anwendungen bei Mammakarzinom-Patientinnen indiziert oder kontraindiziert? Worauf muss man bei einer Bauchspiegelung achten? Gynäkologen begegnen als'Hausärzte der Frauen'im Berufsalltag vielfältige Fragen zur modernen Diagnostik und zu neuesten Behandlungsmethoden, die das ganze, faszinierend breite Spektrum des Fachgebietes der Frauenheilkunde umfassen. Die Buchreihe'Frauenärztliche Taschenbücher'behandelt konsequent aktuelle Themen aus der gynäkologischen Praxis. Deshalb liegen die Schwerpunkte klar auf der Praxisrelevanz und auf der einprägsamen Darstellung der Sachverhalte. Zahlreiche Fallbeispiele mit hochqualitativen typischen Bildern und separat hervorgehobene Merksätze machen die Taschenbücher zu wertvollen Ratgebern und beliebten Begleitern im Berufsalltag.

Wie berät oder behandelt man eine Patientin mit Endometriose? Welche Vorteile hat die diagnostische Hysteroskopie gegenüber anderen Methoden? Wie behandle ich Blutungsstörungen? Sind OC-Anwendungen bei Mammakarzinom-Patientinnen indiziert oder kontraindiziert? Worauf muss man bei einer Bauchspiegelung achten? Gynäkologen begegnen als'Hausärzte der Frauen'im Berufsalltag vielfältige Fragen zur modernen Diagnostik und zu neuesten Behandlungsmethoden, die das ganze, faszinierend breite Spektrum des Fachgebietes der Frauenheilkunde umfassen. Die Buchreihe'Frauenärztliche Taschenbücher'behandelt konsequent aktuelle Themen aus der gynäkologischen Praxis. Deshalb liegen die Schwerpunkte klar auf der Praxisrelevanz und auf der einprägsamen Darstellung der Sachverhalte. Zahlreiche Fallbeispiele mit hochqualitativen typischen Bildern und separat hervorgehobene Merksätze machen die Taschenbücher zu wertvollen Ratgebern und beliebten Begleitern im Berufsalltag.

Despite the substantial efforts made to prevent the disease by early detection, cervical cancer remains a leading cause of mortality among women worldwide. The European Research Organization on Genital Infection and Neoplasia (EUROGIN) pursues a wide variety of educational and training activities, aiming to spread accurate and state-of-the-art information in the field of cervical cancer prevention. The latest outcome of these activities is presented in this book. Providing a concise update of the current knowledge on human papillomavirus (HPV) infections and their intimate link to cervical cancer, the book focuses on five interrelated topics: high- and low-risk HPV infections, methods for HPV detection and use of molecular markers, HPV testing in primary screening and patient management, morphological diagnosis and treatment, as well as prevention of cervical cancer by vaccines. Written by leading international experts, this publication is targeted at a multidisciplinary readership consisting of health care professionals from diverse specialties engaged in the management of HPV-associated diseases.