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Haematology encompasses a broad range of topics ranging from common and relatively benign conditions such as iron deficiency anaemia, hereditary diseases such as thalassaemia, to haematological malignancies that are often life-threatening. Burgeoning information arising from technological advances in recent years has made these subjects particularly challenging for medical students and non-specialist medical practitioners. This book aims to highlight the pathophysiology, clinical presentations and basic principles in the investigations and managements of haematological diseases that are prevalent in Asia. Each chapter begins with a real-case clinical scenario, followed by a set of questions and is complemented by photomicrographs, data charts and illustrations. Readers will have a grasp of the basic knowledge in haematology and the book will be a useful reference in their academic study and clinical encounters.

This fourth edition presents an updated and expanded text and illustrations to reflect continued morphologic, immunophenotypic, and especially molecular advances in the field of neoplastic hematology, mostly due to the rapidly expanding application of next-generation sequencing. Those advances not only allow a more reliable diagnosis of the majority of tumors and identification of early changes such as monoclonal B-cell lymphocytosis or clonal hematopoiesis of indeterminate potential (CHIP), but also in many cases identify mutations or phenotypic changes in tumors that can be targeted by mutation-specific or antigen-specific drugs. This edition incorporates the updated WHO classification of hematopoietic tumors and new immunophenotypic and molecular markers to provide a thorough pathologic overview of hematologic neoplasms while focusing on flow cytometric features. Special emphasis has been put on hematological neoplasms with crucial clinical significance such as acute promyelocytic leukemia, other acute leukemias, and difficult areas in flow cytometry. Flow cytometric features in AML, MDS, CMML, CLL and measurable residual disease were significantly expanded. There are many new comparative tables, illustrations, and diagrams of algorithmic approaches.

This book extensively reviews the purification and structure/function relationships of Factor VIII - von Willebrand Factor with the relevance of advances in the areas of biochemical, methodological and functional aspects to improved methodology and biotechnology.

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn's disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

This atlas presents not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. An expert hematopathologist here provides a valuable resource to understand, use, or interpret one or more of these diagnostic modalities with confidence. This new edition has a compact format with up-to-date information - especially on genetic aspects - and will be an indispensable reference for all professionals in the specialty. •Provides an unrivalled visual resource for differential diagnosis in neoplastic hematopathology •Enables specialist and trainee oncologists and pathologists alike to understand, use, and interpret diagnostic modalities with confidence •Supplies quick access to information via tables, algorithms, and composite figures

Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions.Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathology Modulation of peroxidase-induced biological damage

There is a critical need for iron intake during the first period of life. The growing infant requires iron to synthesize hemoglobin and to supply expanding tissues with iron-containing enzymes. A lack of iron will eventually lead to iron deficiency anemia, one of the most common single nutrient deficiencies in the world. Today, detailed information has increased our understanding of iron bioavailability from different dietary sources, uptake mechanisms of iron into the small intestinal mucosa for transport to hepatocytes and erythropoietic cells and subsequent receptor mediated cellular acquisition. Metabolic effects of iron deficiency have also been investigated in several tissues. This comprehensive text integrates recent information and address it from a nutritional perspective. It takes this focus because of the increased knowledge on the interrelationship between iron and other essential nutrients. Specific problems of iron nutriture and oxidant stress in prematurely born infants are also addressed in this informative new text

Blood microcirculation is essential to our bodies for the successful supply of nutrients, waste removal, oxygen delivery, homeostasis, controlling temperature, wound healing, and active immune surveillance. This book provides a physical introduction to the subject and explores how researchers can successfully describe, understand, and predict behaviours of blood flow and blood cells that are directly linked to these important physiological functions. Using practical examples, this book explains how the key concepts of physics are related to blood microcirculation and underlie the dynamic behavior of red blood cells, leukocytes, and platelets. This interdisciplinary book will be a valuable reference for researchers and graduate students in biomechanics, fluid mechanics, biomedical engineering, biological physics, and medicine.Features: The first book to provide a physical perspective of blood microcirculation Draws attention to the potential of this physical approach for novel applications in medicine Edited by specialists in this field, with chapter contributions from subject area specialists

Transfusion Medicine in Practice focuses on the clinical applications of transfusion, discussing the different settings in which transfusion is carried out, including surgery, transplant, trauma, intensive care, and paediatric neonatal and obstetric cases. The text also includes a full discussion of transfusion products and how to use them, pharmacologic products as an alternative to blood, and transfusion service management. This practical text on the clinical practice of transfusion will be an invaluable resource for all those involved in the use of blood and blood products.

Bone Marrow Processing and Purging: A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow transplantation. Previously, this information was communicated primarily by word of mouth; now experts in the field present detailed descriptions and evaluations of methods for marrow harvesting, evaluation (including tumor infiltration, flow cytometric analysis, and colony assays), comparative methods for automated nucleated cell separation and enumeration, tumor cell purging, T cell depletion, stem cell selection, gene transfer, and cytopreservation. Special sections address quality control and FDA regulations. The book provides a unique information source intended for clinicians, researchers, technical staff, transplant nurses, and medical students involved in this rapidly expanding area of medicine.

The second edition of this atlas has been revised and greatly en-larged to take account of recent diagnostic advances in the field of haematology. It contains 750 color photomicrographs of common and less common cell types, and is intended to supplement the per-sonal study of preparations under the microscope.The photographs are grouped into five sections covering red cells and their precursors; nonerythroid cells of myeloid origin; lympho-cytes, plasma cells and their derivatives and precursors; miscella-neous cells of blood and marrow, including foreign cells and para-sites; and the imprint cytology of lymph nodes and spleen. Each section is preceded by a brief introduction, and an appendix pro-vides technical details of staining methods. The text accompanying the illustrations serves chiefly to identify the cells, but also gives explanations of certain unusual appearances and the cytochemical reactions where necessary.A Colour Atlas of Haematological Cytology will be useful to students of medicine and medical laboratory science, as well as to doctors and technicians specializing in the diagnosis of haematological disease.

First published in 1989: State-of-the-art information on the topic of clinical thrombosis, including an introductory portion dealing with the principles of hemostasis and the pathogenesis of thrombosis, is presented in this text. The use of thrombolytic therapy in acute myocardial infarction is discussed. Other significant advances, such as the identification and understanding of the risk factors contributing to thrombosis such as Protein C and S deficiency, lupus anticoagulants, immune heparin-induced thrombocytopenia, new diagnostic techniques and newer modalities of therapy, are described. Clinical and pathophysiologic features of thrombosis disorders and special situations involving multiple organs are covered. This book also clarifies and updates the usefulness of the various diagnostic techniques.

First Published in 1974, this book offers a full, comprehensive guide into Methemoglobinemia. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.

Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.

Published in 1983: This monograph represents a complete discussion of disseminated intravascular coagulation and related syndromes. Special interest if places upon relating DIC and associated syndromes to all areas of medical specialty where it is commonly seen.

Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.

First published in 1980, Murano and Bick provide well rounded accounts into the effects of Hemostasis and Thrombosis as well as a guide to the general physiology, associated disorders and therapeutic techniques used to address them. This book is ideal for students and practicioners of Hematology as well as those with a general interest in medicine.

First published in 1993: This is the only recent book available that is completely devoted to failures of red blood cell production. A comprehensive review of the physiology of normal and deficient erythropoiesis is presented in a developmental perspective. The chapters provide the most up-to-date clinical concepts and trials, pose the important physiologic questions yet to be answered, and comprehensively review relevant modern technology in the assessment of erythroid failure.A pathophysiologic exposé gives students and others a simplified understanding of the subject. The book provides the clinician with a recommended approach to differential diagnosis, prognosis, and practical therapy for patients with aregenerative anemia. The relevance of biology is stressed by the analysis of animal models of anemia that have enhanced the understanding of erythropoietic failure in man.

First published in 1994, Role of Procoagulant Activity in Health and Disease discusses different aspects of the pathobiology and consequences of the induction of cellular procoagulants. The first part of the book addresses the molecular and cellular biology of procoagulant activity induction (PCA). This includes the recent data on cellular pathways of induction of PCA and the molecular nature of the different procoagulants identified to date. The book addresses interactions between macrophages and endothelial cells, focusing on those aspects most relevant to induction of procoagulant activities, including the role of adhesion molecules. The second portion of the book describes the relevance of PCA to a number of human and experimental diseases, including infectious diseases, gastrointestinal diseases, liver disease, renal disease, neoplastic diseases, allograft rejection, and pulmonary disease. This book will not only be of value to the basic scientist, but also to pathologists and clinicians, and to others wishing to understand the role of immunologically mediated induction of cellular coagulants and their relevance to disease.

First Published in 1988, this book offers a full, comprehensive guide into the workings and treatment of the Blood Vessels. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.

First Published in 1988, this book offers a full, comprehensive guide into the functions and treatment of the Blood Vessels. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.

Fibrinolysis in Disease reviews the state of the art of basic and clinical aspects of the fibrinolytic enzyme system. The text, authored by outstanding and internationally known investigators, is presented in two books.The Malignant Process, Interventions in Thrombogenic Mechanisms, and Novel Treatment Modalities discusses the molecular biology of the system's key components and their fundamental roles in a variety of thrombotic and metabolic disorders. Molecular and Hemovascular Aspects of Fybrinolysis presents the latest findings and concepts of the association between plasminogen activator (u-PA) overexpression and abnormal growth regulation in a variety of solid tumors and in leukemia. One chapter deals with various successful interventions in thrombogenic mechanisms, ranging from exercise and diet to anticoagulants and direct and indirect thrombolytic agents. It concludes with a projection of exciting, novel treatment modalities in thrombotic and malignant diseases.

Published in 1988: This book describes the consequences and implications of the genetic defect for the red cell as a whole.

Published in 1988: This book describes the consequences and implications of the genetic defect for the red cell as a whole.

Many experts now consider genetic evaluation to be pivotal for the optimal diagnosis, classification, risk stratification, and therapeutic decision-making for persons diagnosed with blood cancer. This new text specifically focuses on the genetic alterations essential for establishing diagnosis and assesses how they might impact the precision oncology standard of care. Providing an authoritative review of the state of the art, this is essential reading for physicians, hematologists, and oncologists for optimal management of individual patients.

This fully illustrated text is an essential guide for trainees in Haematology and Medicine studying for higher examinations, as well as for professionals wishing to expand their knowledge or revalidate.The book contains over 100 illustrated cases covering the whole field of malignant and non-malignant haematology, including coagulation problems and infectious diseases. Each case contains a set of questions written by two Royal College examiners, with answers on the reverse page. Readers can make differential diagnoses and devise treatment plans and prognoses, before turning the page to read the experts'detailed answers.The cases are presented in random order – just as they would be in real life – and are of varying lengths and degrees of difficulty, accompanied by hundreds of colour photomicrographs, photographs, and x-rays.This new edition is revised and updated, with new cases, images, and tables.

This book is made possible by the enthusiastic contributions of the authors of the chapters. They have been invited from young and active scientists in the field of t-PA research. I am grateful for their contribution and for the fact that all accepted the specifications of their chapter in order to obtain a structured book. Inevitably, some overlap does exist; on the one hand to enable controversial or unsettled areas to be discussed by the different experts with a different approach and background.It is a particular pleasure and honor that Dr. T. Astrup, as an eye-witness and essential contributor to the history of t-PA discovery and research, gives a unique account of the history of t-PA research in the first chapter of the book.

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into

Diagnostic Lymph Node Pathology presents a logical and systematic approach to lymph node biopsies and guides general pathologists and haematopathologists alike through the maze of differential diagnoses, enabling them to reach an accurate diagnosis.The book is presented in an easy-to-read format and contains boxes for quick reference detailing the clinical, morphological, immunohistochemical, and genetic features of each entity. Thoroughly revised, the third edition also includes more than 300 high-quality histological colour photographs along with updated references.This edition covers both classical and less well-known features of individual disease processes. It is a valuable guide for both professionals and trainees.

This third edition is the product of the author's 25 years of experience with flow cytometry; although it covers the wide spectrum of hematopoietic tumors, the focus remains on most important clinical diagnoses, such as acute promyelocytic leukemia, identification of blasts, identification of clonal B-cell population, differentiating mature versus immature T-cell proliferations, deferential diagnosis between hematogones and B-ALL or distinction between chronic and acute monocytic proliferations. All hematopathologists and neoplastic hematologists will find this an important resource for keeping up to date with developments in clinical practice.

Management of tumor patients now relies on new individualized approaches to treatment, requiring extensive knowledge of the molecular makeup of tumors. Updated and expanded, the third edition of Atlas of Differential Diagnosis in Neoplastic Hematopathology examines not only the differential diagnosis but also the detailed morphologic, immunophenoty

Highly Commended, BMA Medical Book Awards 2014Chronic myeloid leukemia is a clonal disease that results from an acquired genetic change in a single pluripotential hemopoietic stem cell. Efforts to confront this disease have been assisted by advances in cellular and molecular biology and the speed at which these findings have transformed the therapeutic algorithm. Nevertheless, there is some uncertainty with regards to how best to assess efficacy of treatment, especially with regards to the most appropriate surrogate markers for overall survival. From the standpoint of biology and clinical management, this handbook provides an authoritative state-of-the-art review of current and developing progress.

Although first reported in 1973, immune heparin-induced thrombocytopenia (HIT) remains one of the most frequent and devastating adverse drug reactions encountered by physicians. This thoroughly updated fifth edition from international experts Professors Warkentin and Greinacher is the gold standard for accurate diagnosis and management of this cond

The fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to

Red blood cells in humans-and most other mammals-have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this real

An ideal text for radiation oncologists, hematologist-oncologists, and radiologists, Image-Guided Radiotherapy and Functional Imaging in Modern Lymphoma Management is the foremost source for information on the increasingly important subject of image guided radiation therapy (IGRT) and its crucial role in the clinical evolution of high-precision ion

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengt

Custom-designed for clinicians on the frontline of treatment and prevention of the human papillomavirus (HPV), this stand-alone handbook provides the scientific background needed to understand and administer the new HPV vaccines. Written by some of the discoverers of these vaccines, this accessible text explores the biology and epidemiology of HPV,

As the number of patients with thrombosis and thrombolysis increases, there is a critical need for clinicians to learn the latest scientific discoveries and treatment options. This timely Third Edition is a comprehensive text for cardiologists, hematologists, and pharmacologists in need of a resource on current agent development technology for trea

Written by a team of leading authorities in pathogenesis, diagnostic techniques, and clinical management strategies in myelodysplastic syndrome (MDS), this text provides a concise, easy-to-follow review of the advances in the science, classification, diagnosis, and management of the condition. An ideal source for hematologists, oncologists, and can

A cross between a dictionary and an encyclopedia, Desk Reference for Hematology, Second Edition presents a concise yet thorough examination of hematology and its relationship with other systems and disorders. The 1500 alphabetically listed articles provide quick and easy access to expert information, the 150 tables put precise data at your f

With the new classification of chronic myeloproliferative disorders, and the rise of interest in molecularly targeted therapies, this timely text brings together international experts on the topic to discuss the current technologies and their implications for the treatment of patients.This title comprehensively covers chronic myeloid leukemia and P

Innovative Leukemia and Lymphoma Therapy provides a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as:tyrosine kinase inhibitors, histon deacetyla

Written with a broader perspective and knowledge, Cancer Supportive Care: Advances in Therapeutic Strategies presents state-of-the-art management options for the full range of symptoms, toxicities, and complications experienced by cancer patients. In addition to'bread and butter'topics such as pain control and nausea and vomiting, the book contai

Hematology data from in vivo toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials.Covering the three main blood cell types - erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics fo

Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides

Multiple myeloma is the second most prevalent hematological malignancy, with over 55,000 new cases diagnosed each year. This exciting new text, edited by lauded authorities on the topic, stands as the only available reference to assemble, review, and synthesizes the latest studies on translational therapies and clearly explains the impact of molecular pathogenesis, biology, and prognostic factors on the diagnosis, prognosis, and individualization of treatment and the development of novel therapeutic options for patients with myeloma.

With the recent discovery of JAK2 mutations in myeloproliferative disorders, medical science has taken a revolutionary stride forward toward understanding the pathogenesis of these diseases. This new advancement translates not only to a more rapid and reliable diagnosis, but also allows groundbreaking research into the development of new therapeuti

Written by authors from the world's most prominent cancer centers, Chronic Lymphocytic Leukemia supplies a comprehensive, up-to-date picture of CLL and how to better treat patients inflicted with the disease.New information on developments in the molecular pathogenesis of this disease impacts how physicians approach and treat patients with CLL. The various predisposing factors for the disease are addressed along with current and future treatment modalities and recommended standards of care.

In September of 2007 Gaucher Disease received a commendation in the Haematology category of the 2007 British Medical Association Medical Book Competition!Although rare in the general population, Gaucher disease is the most prevalent of the lysosomal storage disorders, making research into this particular orphan disorder an invaluable proto