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This book contains the contribution to the 36th Hemophilia Symposium, Hamburg 2005. The main topics are epidemiolgy, hemophilia therapy, orthopedic treatment in hemophiliacs, hemostaseologic diagnosis and pediatric hemostaseology. The volume is rounded off by numerous free papers and posters on hemophilia, inhibitors in hemophilia and diagnostics.

First published in 1980, Murano and Bick provide well rounded accounts into the effects of Hemostasis and Thrombosis as well as a guide to the general physiology, associated disorders and therapeutic techniques used to address them. This book is ideal for students and practicioners of Hematology as well as those with a general interest in medicine.

The latest edition of this practical handbook provides a concise yet comprehensive overview of common and rare problems with hemostasis and thrombosis. Through thoroughly updated and revised chapters, the text features practical information on diagnosing and managing troublesome hematologic conditions often found in clinical practice. The handbook also spotlights advances in the field since the publication of the last edition, including multiple novel coagulation factors for hemophilia, the increasing use of novel anticoagulants and their reversal agents, and the increasing use of genetics for diagnosis. Written by experts in the field, Hemostasis and Thrombosis, Fourth Edition is an invaluable resource for healthcare professionals who treat patients afflicted with these conditions.

In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike.

This book offers a thorough, clinically oriented review of hemostasis and its impact on the practice of dentistry. Readers will gain a sound understanding of the pathophysiology of hemostasis and the pharmacology of antithrombotic and prothrombotic medications. Perioperative dental management strategies of value in patients with different congenital and acquired disorders of hemostasis are carefully explained, and the role of surgical techniques and local and topical agents in helping to minimize and control bleeding is described. Helpful instruction is also provided on the indications for antithrombotic medications and the management of patients receiving such therapy, including the risks of altering medications. As the number of available oral antithrombotic agents continues to increase, dentists will encounter significantly more patients receiving treatments that affect hemostasis. In presenting comprehensive, up-to-date information on hemostasis, hemostatic disorders, antithrombotic therapy, and safe dental management, this book will serve as a rich source of information and a useful guide for practitioners and students alike.

First published in 2006, the bestselling Wintrobe's Atlas of Clinical Hematologyhas now been comprehensively updated by a brand-new editorial team to bring you state-of-the-art pictorial coverage of the complete range of hematologic conditions. Thousands of meticulous, full-color images capture the characteristic appearance of each pathologic entity, and concise descriptions point out features of diagnostic importance. The result is a peerless reference to facilitate confident diagnosis in hematology.

Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects, Third Edition, is the only pocket-sized, quick reference for pathology and transfusion medicine residents and fellows. It covers all topics in transfusion medicine and clinical and laboratory-based coagulation. Chapters are organized by multiple hierarchical headings and are supplemented with up to 10 suggested reading citations. This single handbook covers all the topics required to meet the goals of a major program in transfusion medicine and clinical coagulation. Changes to this edition include the latest AABB standards and new chapters focused on a wider range of specific populations requiring blood and related products. Coverage includes essential updates on peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in therapeutic apheresis and new cellular therapies. - Includes new chapters on blood products, new methods for product modification, and an expanded section on clinical settings, including new chapters on a wider range of patient populations - Teaches through a new case study format with concise bullet points, essential tables, and further reading lists - Presents information in a standardized format throughout, allowing each chapter to be focused on a well-defined subject consisting of less than 6 pages

Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. Provides essential practical management for all those working in the field of hemostasis and thrombosis Includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading Highlights controversial issues and provides advice for everyday questions encountered in the clinic

This updated and extended edition of the SickKids Handbook takes the reader through the entire field of pediatric thrombosis and hemostasis. An introductory section concisely explains the complex pathophysiology of thrombosis and hemostasis. The chapters that follow include practical, evidence-based information on the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children. Special features include practical clinical algorithms and appendices that cite normal laboratory reference ranges, as well as recommended dosages of blood products and major hemostatic agents. A stand-alone chapter is dedicated to developmental hemostasis and bleeding in the neonate. A chapter on antithrombotic therapy in children gives succinct information on the old and new anticoagulants, antiplatelet drugs and thrombolytic agents. Written and reviewed by international experts in the field, this handbook is intended for health care professionals involved in the assessment and care of children with inherited and acquired bleeding and clotting disorders, including general and specialist pediatricians (in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists), hematologists/oncologists (pediatric and adult), as well as medical trainees, nurses, nurse practitioners and pharmacists.

In this second edition of Disorders of Thrombosis and Hemostasis in Pregnancy - A Guide to Management the content has been thoroughly updated, with a particular focus on strengthening the management sections to ensure that advice on management represents state of the art.

Coagulation testing is the basis for the diagnosis of bleeding and thrombotic disorders, as well as the mainstay of anticoagulant monitoring and management. This handbook provides practical information and guidance on topics relevant to directing a coagulation laboratory, filling a void in the literature. Since the first edition, all chapters have been updated and an entirely new chapter is included on pharmacogenomics and pharmacogenetics. The book will aid pathologists, clinical laboratory scientists and other physicians serving as laboratory directors to understand and carry out their responsibilities. It will also assist residents and fellows in learning the basics of coagulation testing and serve as a useful day-to-day reference for coagulation laboratory supervisors, technologists, and technicians. Finally, clinicians may find aspects of the book helpful in understanding the role of the coagulation laboratory in patient evaluation and monitoring.

Since the second edition of Hemostasis and Thrombosis published over a decade ago, advances on assessing, treating and preventing common and rare hemostatic problems have emerged. This latest edition features these new developments while providing practical information on diagnosing and managing these troublesome conditions often found in clinical practice. Concise and convenient, healthcare professionals will find this text to be an invaluable resource.

The author examines hemostasis in animals from all seven major vertebrate classes. Her research provides unique insights into the phylogenetic development of the various phases and components of hemostasis. This monograph is a valuable reference for students, researchers, and teachers of biology, zoology, veterinary science, and human medicine.

A unique clinical focus makes Consultative Hemostasis and Thrombosis, 3rd Edition your go-to guide for quick, practical answers on managing the full range of bleeding and clotting disorders. Emphasizing real-world problems and solutions, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler provide all the clinical guidance you need to make optimal decisions on behalf of your patients and promote the best possible outcomes.Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located.Efficiently look up concise descriptions of each condition, its associated symptoms, laboratory findings, diagnosis, differential diagnosis, and treatment.Get the latest information on hot topics such as Disseminated Intravascular Coagulation, Thrombophilia, Clinical and Laboratory Assessment and Management, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia.Apply today's newest therapies, including those that are quickly becoming standard in this fast-changing field.Meet the needs of specific patient groups with a new chapter on Bleeding and the Management of Hemorrhagic Disorders in Pregnancy and an extensively updated chapter on Thrombosis and Cancer.Zero in on key information with a new user-friendly design, and all-new full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout.

A Karger'Publishing Highlights 1890–2015'title This handbook takes the reader through the entire field of pediatric thrombosis and hemostasis. An introductory section concisely explains the complex pathophysiology of hemostasis and thrombosis. The chapters that follow include practical, evidence-based information on the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children. Special features include practical clinical algorithms and appendices that cite normal laboratory reference ranges, as well as recommended dosages of blood products and major hemostatic agents. A stand-alone chapter is dedicated to developmental hemostasis and bleeding in the neonate. A chapter on antithrombotic therapy in children gives succinct information on the old and new anticoagulants, antiplatelet drugs and thrombolytic agents. Written and reviewed by international experts in the field, this handbook is intended for health care professionals involved in the assessment and care of children with inherited and acquired bleeding and clotting disorders, including general and specialist pediatricians (in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists), hematologists/oncologists (pediatric and adult), as well as medical trainees, nurses, nurse practitioners and pharmacists.

Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs. NEW to the Sixth Edition… • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives. • Full color throughout • A companion website that offers full text online and an image bank. • A new introductory section of chapters on basic sciences as related to the field • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups. • Overview chapters preceding each section address broad topics of general importance. This is the tablet version which does not include access to the supplemental content mentioned in the text.

Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents. With the increase average age of the population coupled with changes in life style in recent years, there has been a significant increase in cardiovascular and hematological disorders. Thus scientists in both academic institutions as well as the pharmaceutical industry are developing better therapeutic agents to improve the quality of life. This impetus has lead to the search for novel agents from various sources that interfere withcardiovascular and hematalogical processes. Although at first glance exogenous factors appear to function as ‘villains', several life-saving drugs have been developed based upon these factors. Such drugs or drug leads include those that inhibit the angiotensin converting enzymes (Captopril and Enalapril), that block platelet receptors (Eptifibatide and Tirofiban), or that digest thrombotic plugs (Alfimeprase and bat plasminogen activator) to name a few. Several new and exciting success stories are currently unfolding. In this book, recent studies on some of the exogenous factors that play crucial roles in cardiovascular and hematological disorders are reviewed in order to consolidate the efforts in this area of research and to recruit new, talented researchers. The 25-30 review chapters, each written by experts in their field, compiled herein are devoted to exogenous factors affecting platelet aggregation, anticoagulant and procoagulant proteins, fibrinolytic proteins and hypotensive agents (For details see, Contents of the Book). This book is intended to help to create elevated awareness and enthusiasm in the field of exogenous factors. I believe that this book will provide greater impetus to the search for novel proteins based on naturally occurring exogenous factors. This will be the first book dealing extensively with exogenous factors in the last 25 years. The book will provide a ready reference to the different approaches used to solve complex problems in protein chemistry and pharmacology of exogenous factors. The book will update our understanding of the structure-function relationships and mechanisms of action of exogenous factors and provide great insights into future directions for solving the remaining challenges.

Transfusion Medicine and Hemostasis is a manual-style book that links transfusion medicine and hemostasis to laboratory methods and diagnostic tests engaged in routine and specialized coagulation laboratories. The book is divided into two main parts with chapters that are brief and readable. The first main part of the book is subdivided into blood banking and transfusion medicine. Under blood banking, the chapters cover blood collection, donation process, component manufacturing, donor testing and storage; transfusion-medicine chapters examine the components for transfusion, pre-transfusion immunohematology testing, blood groups, blood products and their modifications, approaches to transfusion therapy in specific clinical settings, and transfusion reactions and complications. In addition, chapters that talk about apheresis, cellular therapy, and tissue banking in the hospital setting are included. Hemostasis, the second main part of the book, is subdivided into three sections. The first section, clinical coagulation, includes chapters about neonatal thrombocytopenia, inherited platelet function disorders, immune thrombocytopenia, immune-mediated coagulopathies, congenital bleeding disorders, and acquired bleeding disorders. The second section relates to laboratory testing of coagulation, with chapters about laboratory assessments of platelet disorders, von Willebrand disease, coagulation factor disorders, fibrinogen and fibrinolysis, tests for hypercoagulable state and for activation of the coagulation system, and laboratory support for anticoagulation. The third section discusses coagulation factor products. This book will be valuable for the education of trainees, practitioners, and future leaders in these fields.

This practical guide provides all the information necessary to understand the clotting mechanisms, as well as how to prevent, diagnose, and treat bleeding and clotting disorders. Practical Hemostasis and Thrombosis has been updated to reflect all the important advances made since the first edition. It includes an in-depth description of platelet abnormalities and disseminated intravascular coagulation, as well as covering the laboratory and molecular biological tests needed for the diagnosis of bleeding and clotting disorders. Clinicians will find useful advice for everyday questions in each specialty area as the book describes hemorrhagic and thrombotic problems in cardiology, neurology, hepatology, nephrology, oncology, obstetrics, pediatrics, intensive care and transfusion medicine. An invaluable resource for all hematologists, trainee hematologists preparing for examinations and clinicians this book should be kept close at hand for frequent consultation

Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.

Effectively and efficiently diagnose and manage today's full range of clotting and bleeding disorders using clinical case studies that demonstrate real-world problems and solutions! For each condition examined, you'll review concise descriptions of its associated symptoms, along with laboratory findings, diagnosis, differential diagnosis, and treatment - all the clinical guidance you need - at your fingertips. It's the ideal real-life reference tool for busy physicians!A reader-friendly design, coupled with nearly 385 illustrations and at-a-glance tables - many new to this edition - equip you to quickly locate the guidance you need.Abundant laboratory protocols enable you to select and interpret lab tests more easily.A complete section on women's health issues helps you stay current in this evolving area. A new chapter on the impact of herbal medicines examines their effect on hemostasis and their interaction with other drugs.New coverage of hemostatic issues in traumatology, sepsis, interventional radiology, pulmonology, and cardiology allows you to master the latest advances.

Provides a comprehensive yet concise and practical guide to the full range of clotting and bleeding disorders encountered in clinical practice. Presented in three sections, this book informs and advises clinicians in all stages of diagnosis, management and prevention of thrombotic and hemostatic disorders. Why Buy This Book? Essential practical management for all those working in the field of haemostasis and thrombosis A comprehensive yet concise and practical guide to the full range of clotting and bleeding disorders encountered in clinical practice. Advice to guide clinicians through the diagnosis, treatment and prevention of thrombotic and haemostatic disorders Each chapter to follow a standard template supplemented with a mini-contents list, key points, further reading and a summary box Highlights controversial issues and provides advice for everyday questions

With contributions from a team of specialists, Women's Issues in Thrombosis and Hemostasis examines the background and current management of a range of topics. Along with a comprehensive overview of basic principles, the book explores common clinical issues, including complications of pregnancy, such as inherited or acquired thrombophilia and the r