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This book contains the essential information required by physicians and bench scientists to understand the definition of a given autoimmune disease and its diagnostic criteria and treatment. Autoimmune diseases are a family of more than one hundred chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Autoimmune Disease Diagnosis: Systemic and Organ-specific Diseases, the editors have gathered a critical review by renowned experts of more than 120 autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. This edition of Autoimmune Disease Diagnosis is divided into two parts, the first covering systemic autoimmune diseases, and the second covering organ-specific autoimmune diseases. They cover all the newly approved classification criteria, such as those for systemic lupus erythematosus, antiphospholipid syndrome, several systemic vasculitis, etc. This edition also reviews newly described systemic autoimmune conditions: immune-mediated necrotizing myopathy, VEXAS, immunoglobulin G4-associated autoimmune disease, autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA), and autoimmune manifestations induced by immune-therapies. Several organ-specific diseases have been added, including autoimmune alopecia and other immune-mediated dermatosis, autoimmune encephalitis, and autoimmune dysautonomia, among others. This is an essential guide to the diagnosis of autoimmune diseases for internists, rheumatologists, clinical immunologists, primary care physicians, and bench scientists.

This practical guide provides radiation oncologists with clear, practical guidelines for delineating target volumes and radiation fields for a diverse group of hematologic malignancies. The treatment fields and volumes described in this guide can be used when treating with conformal therapies, such as intensity-modulated radiotherapy (IMRT) and/or proton therapy. Each chapter focuses on clinical target volume (CTV) contouring for specific hematologic malignancies, including lymphomas, leukemias and plasma cell neoplasms. Since target volumes can be complex in certain clinical circumstances, each chapter includes multiple, detailed illustrations of the volumes in representative cases contoured slice by slice in the planning CT images, with accompanying diagnostic images that are commonly used in image fusion. The book will be a valuable resource for practicing radiation oncologists, medical physicists, medical dosimetrists, residents, radiation therapists and other medical professionals.

The second edition of this text has proved to be a very successful pediatric study guide, helping many pediatricians around the world to study pediatrics in a very easy, simplified way. Even the most complex subjects are condensed into very straight forward and easy to remember information blocks. This book not only prepares students to pass their exams but also prepares pediatricians for general pediatric encounters, emphasizing all new updates from the American Academy of Pediatrics and American Board of Pediatrics. It has proved very popular among new pediatricians and new pediatric residents worldwide. In the last 3 years, the AAP and ABP have released a lot of updates, such as, management of fever in well-appearing infants, COVID-19, asthma management, and new vaccine guidelines from the CDC. The pediatric board exam always includes new diseases, which are included in each chapter, as well as new questions and answers that must be added to the last-minute review chapter, as well as other questions to be edited to follow the new recommendations and guidelines in pediatrics. New pictures and better quality illustrations are also included. Pediatric residents and fellows preparing for the board examination, pediatricians, and pediatric subspecialists preparing for certification maintenance will find Pediatric Board Study Guide: A Last-Minute Review, 3rd edition, easy to use and comprehensive, making it the ideal resource and study tool.

In recent years anesthesiologists have developed a more active role in the entire peri-operative period-from the decision for surgery, through recovery, discharge and beyond. In addition, the core training curriculum of anesthesiology has changed significantly to now include many non-operating room anesthesia rotations.General anesthesiology texts include varying degrees of perioperative management information, and a few titles are devoted specifically to the area. However, none combines a problem-based approach with review questions and answers with explanations. Following the format of the Anesthesiology Problem-Based Learning Approach series, each chapter in Perioperative Medicine describes a specific condition or situation and a virtual case presented through a series of questions and answers. With 48 chapters covering a broad array of conundrums encountered in clinical perioperative medicine, the text focuses on preoperative optimization of patients with different comorbidities, such as coronary artery disease, heart failure, chronic obstructive pulmonary disease, obstructive sleep apnea, diabetes mellitus, cirrhosis, substance use disorder, and anemia. Sections on how to choose preoperative tests, medication management, and handling ethical issues, like informed consent, DNR, and uncomfortable conversations with patients, are discussed in detail. Perioperative Medicine: A Problem-Based Learning Approach provides an up-to-date compendium of topics commonly presenting in daily practice and serves as a unique learning opportunity for the busy perioperative clinician approaching a new case and for clinicians in training who need to learn the basics.

Certain diseases may involve organ systems that cross the boundaries of specialties. For instance, a patient with scleroderma can develop interstitial lung disease, or a patient with relapsing polychondritis can have the clinical manifestation of subglottic stenosis. This book represents a collaboration between specialties, helping clinicians recognize the implications of disease both within their own specialty and in the overlapping specialty. Here, leading experts from the fields of rheumatology and pulmonology provide a masterclass in the care of patients with systemic illnesses that involve the immune system and the lungs.Key Features: Provides an evidence-based clinical approach to the patient with pulmonary manifestations of rheumatic disease Details cutting-edge research with input from the world's leading experts Discusses possible future directions for research and advancement

MEDICINE UPDATE • Medicine Update is being published as a comprehensive two-volume book divided into 20 sections comprising 281 chapters. • It includes chapters from leading experts from the field of medicine from India and overseas. • The book is a compilation of the current understanding of various aspects in medicine and up-to-date information from the available research data. • The book may prove to be a valuable resource for physicians and postgraduates in their day-to-day practice. PROGRESS IN MEDICINE •This book includes the scientific proceedings of the CME of APICON 2024. •It is organized into parts for different systems covering a wide range of pertinent clinical subjects. •It is helpful in everyday decision-making as well as postgraduate examination. •Recent updates on evidence-based guidelines for management and clinical medicine are provided. •This book includes chapters contributed by specialists in genetics, modern technology, and fundamental sciences. •Some chapters focus on soft skills, which are becoming more crucial in today's world •Topics that are frequently overlooked, like travel medicine, medical education, medicolegal concerns, and gerontology, are also included.

The second volume of the book Emerging Human Viral Diseases discusses pathogenesis, diagnostics, and therapeutic strategies against viral encephalitis, gastroenteritis, and human immunodeficiency viral infections. The chapters discuss symptoms, diagnostics, and preventive strategies against viral infections. The book also reviews the epidemiology and evolution of viruses causing these infections. It also examines symptoms and strategies for developing novel diagnostics and the vaccine against these viruses. Toward the end, it discusses various biosafety principles for handling emerging viruses and reviews various bioinformatics tools and databases in virology research. This timely book offers valuable resource for the scientists working in the field of emerging viral infections and those involved in preventing, controlling, and managing viral diseases. Inclusively this book will be valuable guide covering most recent scientific progress in emerging human viral diseases and management and will serve as the best resource for undergraduates, graduates, medical professionals, researchers, public health physicians, and national and international health authorities.

Unlocking the Future of Infectious Disease Research ResponseIn a world where emerging infectious diseases constantly threaten humanity, advances in science and technology promise defense against future pathogens before they cause pandemics. The field of emergency research response and preparedness remains in its infancy, however. Not until the 2014 West African Ebola outbreak was accelerated research broadly recognized as a crucial component of emergency response. Many outbreaks and one global pandemic later, it is clear the world must be prepared to launch accelerated research responses to prevent or mitigate infectious disease outbreaks, epidemics, and pandemics. Yet this nascent field is rife with critical scientific, ethical, and policy questions. How can local, national, and global systems collaborate across disciplines and political boundaries to protect health security? How can we conduct rigorous research in fragile or failed nation-states? What is needed for equitable distribution of vaccines and therapeutic medicines in short supply? How can we accelerate trials of vaccines and therapeutics during an emergency without compromising scientific rigor or ethical standards? How do we integrate communities and stakeholders into research preparedness and response? The editors bring decades of experience to their collaboration with renowned research scientists and health policy experts. Together they have crafted a compendium that proposes normative standards and offers practical guidance for preparedness and rapid research response. This pioneering, open access textbook presents principles and practices forged from experience in health emergencies – insights that illuminate a path forward for research response and preparedness. The goal is to stop outbreaks from becoming avoidable pandemics, and to mitigate illness, death, and social disruption if they cannot be stopped. Principles and Practice of Emergency Research Response merges historical understanding with insights into possible futures. It will serve as an indispensable compass for curtailing infectious disease threats through research, global health policy changes, and research capacity improvements where they are most needed. The editors hope that this book will be an ongoing reference for governments, health organizations, development agencies, researchers, policy experts, ethicists, and social scientists. To facilitate focused and enhanced learning, it incorporates pedagogical tools such as abstracts, learning objectives, discussion questions, real-life examples, and learning tracks. Robust global health security requires effective preparation for and response to emerging and re-emerging pathogens. This volume should help guide us towards a more resilient future.

The first of two companion books addressed the biology and clinical aspects of ovarian cancer. The companion title, Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies, discussed both classic and the most recent imaging approaches for detection, early diagnosis and treatment of ovarian cancer. This volume, Cell & Molecular Biology of Ovarian Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to ovarian cancer. Taken together, these two volumes form one comprehensive and invaluable contribution to the literature.The first of two companion books addressed the biology and clinical aspects of ovarian cancer. The companion title, Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies, discussed both classic and the most recent imaging approaches for detection, early diagnosis and treatment of ovarian cancer. This volume, Cell & Molecular Biology of Ovarian Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to ovarian cancer. Taken together, these two volumes form one comprehensive and invaluable contribution to the literature.

Now in its second edition, Hematology Board Review has been thoroughly revised and updated to contain the latest information that fellows and clinicians need to successfully prepare for the Hematology Certification Exam administered by the American Board of Internal Medicine (ABIM). The new edition now contains even more high yield board study content and review questions. For the hematology-oncology fellow, hematologist, medical oncologist, or internist looking to review a given disease or blueprint category prior to their examination, this extremely practical study guide provides the pertinent points of emphasis that are often highlighted on the exam. Chapters on blood disorders and disease sites cover epidemiology, etiology and risk factors, staging, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. Clinical pearls on other major subspecialty areas found on the exam include hematologic emergencies and supportive care, transfusion medicine, stem cell biology and hematopoiesis, cellular therapy, management of hematologic disease, complications after cellular therapy, and biostatistics. With 240 practice questions, detailed rationales, and a convenient print + digital package, Hematology Board Review gives you the tools to study your way and the confidence to pass the first time! Key Features: Aligns with the latest Hematology Certification Exam ABIM blueprint Provides a comprehensive yet concise review of all hematologic malignancies, blood disorders, transfusion medicine, cellular therapy, standard treatment regimens, and biostatistics Revised to include new treatment recommendations and FDA approvals Includes end-of-chapter assessment questions with detailed rationales - a total of 240 questions

Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs, Second Edition is a visually engaging reference detailing the essential basic and clinical science of all approved, effective, and life-prolonging drug therapies in oncology. Now with a greater emphasis on clinical context, application, and management in each chapter, this significantly revised edition provides both early-career and seasoned clinicians with a practical, bench-to-bedside approach and patient-oriented guide. The book provides detailed coverage of the major advances in cancer pharmacology at the forefront of our standards of care for solid tumors and hematologic malignancies, in addition to the basic science that is directly necessary and applicable when at the patient's bedside. Everything from traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents is explored, in addition to a new chapter covering pharmacogenomics. Accompanied by elegant illustrations, each chapter details the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic and molecular properties of the various agents, and their mechanisms of action. The book covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Thoroughly updated to include new FDA-approved treatments and applications, and written by leading experts in cancer pharmacology, this second edition continues to be a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology, including clinicians, pharmacists, nurses, and trainees. Key Features: Over 150 beautiful illustrations depict structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Contains more than 160 high-yield hematology and oncology board-style chapter review questions (more than double the previous edition) with descriptive rationales Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work, and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other treatment modalities Thoroughly updated and revised chapters cover new FDA drug approvals, disease-site indications, clinical applications and management of drug-to-drug interactions, and toxicities Discusses challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments Provides important pharmacotherapy context with clinical pearls in each chapter that help support a patient-oriented, bedside approach

This title provides a practically applicable guide to the use of immunomodulators and biologics to treat cutaneous diseases. Chapters cover the mechanisms, applications and safety concerns pertaining to the latest systemic therapies. Extensive guidance is provided on how to design lab monitoring schedules, manage patient follow-up visits, develop tapering plans and assess adverse outcomes. The book also reviews how to initiate off-label applications and establish methods of matching mechanisms for a range of diseases to the mechanisms of the available therapies. The latest updates in the development and utility of systemic immunomodulators, biologics and JAK Inhibitors from clinical trials and updated guidelines are also discussed. Immunomodulators and Biologics in Dermatologic Treatment comprehensively describes the use of a range of systemic therapies for immunomodulation in dermatology and how best to incorporate these into practice. It therefore represents a valuable resource for novice readers and experienced dermatologists involved in the management of these patients.

This book is a comprehensive guide on microbiome research, from the fundamentals of to the latest advancements in microbiome-based therapeutics. The initial chapters introduce the concept of the human microbiome delving into the intricate relationship between the human host and its microbiome. The chapter also examines the various tools and techniques used in microbiome research and the role of computational biology in analyzing vast amounts of microbiome data. The subsequent chapters review the role of the microbiome in various health conditions, including metabolic disorders, immunological disorders, gastrointestinal tract disorders, management of cancers, metabolic disorders, and mental health disorders. Towards the end, the book examines the regulatory considerations surrounding microbiome-based therapeutics, and ethical considerations surrounding microbiome-based therapeutics. This book is a comprehensive and cutting-edge guide for researchers, healthcare professionals, and students interested in the field of microbiome research and its potential for transforming healthcare.

Interdisciplinary Rheumatology: Rheumatology and Gastroenterology is the first complete textbook to examine the myriad complications of rheumatic syndromes in the gastrointestinal tract. Each disease is summarized for a broad medical audience, with focus on the consequences of the disorder throughout the gut. The reader will formulate an understanding of the clinical, pharmacological, and nutritional aspects of the interface of these two specialties with expert contributors from a range of academic centers. Rheumatologists and gastroenterologists will be able to recognize, evaluate, and treat gastrointestinal symptoms of autoimmune diseases and collaborate in improving the experience and outcomes of these complex patients.

This book offers an insightful exploration into the relationship between diet and Multiple Sclerosis (MS), aiming to address a crucial question: Can dietary interventions serve as effective preventative and therapeutic measures for patients with MS? Delving into this question, the book examines various nutritional components and regimens, shedding light on their potential impacts on the progression, relapse rate, and development of MS. It offers readers valuable insights into how dietary choices can influence the management of this condition. Backed up by evidence gathered from review and clinical trial papers, the book discusses the role of vitamins such as A, B, and D, as well as dietary supplements like caffeine, carnitine, and lipoic acid in benefiting patients with MS. Particular attention is given to the significance of vitamin D in lowering the risk of developing MS and its immunomodulatory effects on the inflammatory processes associated with the disease. In parallel, the book also addresses the detrimental effects of diets such as the Western or high salt diet (HSD) on MS prognosis, emphasizing how these dietary regimens can harm the gut microbiome and exacerbate inflammatory responses, ultimately promoting demyelination of the central nervous system (CNS). The book then explores alternative dietary approaches that confer a protective effect on the gut microbiome and the CNS, including whole grain, fasting, Mediterranean, and ketogenic diets. This comprehensive resource is an essential reading for patients with MS seeking to understand the potential impacts of diet on their overall health, as well as healthcare professionals and researchers interested in exploring dietary interventions for MS management.

This book highlights the role of vitamins in preventing or reducing the pathogenesis or treatment of infectious viral diseases based on current ongoing research and past work. Using clinical evidence and trials that suggest the potential benefits of vitamin supplementation as prophylactic and therapeutic in infectious viral diseases, each individual vitamin is described in this context in separate chapters. It will be a valuable reference aid to researchers, clinicians, and medical bodies to develop improved therapeutic regimens.Key Features: Acts as a one-stop resource on the relevance of vitamins in infectious viral diseases. Provides a clinical focus on disease prevention and therapy using vitamins for clinicians and researchers. Discusses the molecular mechanisms of vitamins in COVID-19 and other viral diseases.

Preserving good skin condition has significant quality of life implications for diabetic patients, especially for those suffering from related ulcers or diabetic foot syndrome. This timely work on the cutaneous manifestations of diabetes offers an interdisciplinary approach to help the practitioner's differential diagnosis and choice of the best therapeutic options. Starting from the broader picture to focus successively on infections of the skin, problems resulting from reduced circulation, leg ulcers, it also includes parts on wound and skin care. Chapter topics include complications and imaging, dermatoses and (auto) inflammatory skin diseases. Richly illustrated and presented in a clear style, Cutaneous Manifestations in the Diabetic Patient is meant for clinical dermatologists, general practitioners, internal medicine practitioners but will be a valued companion to nursing personnel and health care professionals involved in the care of diabetic patients, enabling early detection and safe management.

The purpose of this unique title is to provide internal medicine residents and physicians, as well as other professionals engaged in internal medicine practice, with a single resource of comprehensive, abundantly helpful, time-saving training and practice notes. Developed by a now highly experienced hospitalist physician during his three years'residency training in internal medicine, as well as during his current role as a practicing hospitalist, these notes provide a broad framework and tool not only for the learning and practicing of internal medicine after graduation from professional schools and during training, but after residency training as well. The majority of the notes were presented as one to a few sentences, rendering the information succinct and easy to digest. The notes also provide simple, key information in patient care including, but not limited to, the workup and management of a wide range of clinical scenarios. The book was divided into three general areas -- 1) daily notes taken during the author's residency training (in the format of a diary with the original dates but updated knowledge and information), 2) notes for outpatient medicine and clinical subspecialties, and 3) notes as a hospitalist. The daily notes were based on knowledge and experiences the author learned from actual clinical cases (workup, medication regimen, patient education, and sometimes patient and family interactions). The notes for outpatient medicine and clinical subspecialties were based on specific topics/subspecialties and were heavily clinically oriented with a focus on patient care. The addition of notes as a hospitalist was based on the author's duties as a hospitalist, which requires knowledge and understanding of acute neurological and neurosurgical issues, various types of cancers, and some common yet complicated or uncommon clinical scenarios of infectious diseases. A major contribution to the internal medicine education literature, Internal Medicine Training Notes and Survival Guide: An Insider's Roadmap for the Journey from Resident to Attending Physician will appeal to a wide readership, including resident physicians, practicing physicians, physician assistants, and nurse practitioners in internal medicine.

The fourth edition of this compilation has seen qualitative improvements over the previous editions has been aligned to the new CBME curriculum. While the contents of the book are comprehensive, presentation is simple. Clinical images, tables, boxes, algorithms and diagrams are simple and enhance the learning. This book will definitely be an essential learning tool for students of internal medicine.

This fully revised and expanded second edition provides a comprehensive and up-to-date overview of nasal rhinitis polyposis, a condition that not only decreases patients'quality of life, but also affects the connections between the upper and lower respiratory tract, making its treatment of critical importance. New research findings, as well as new technical innovations, have changed the conventional medical and surgical approaches to the treatment of nasal polyposis, which has resulted in significant advances in the management of the disease. This reader-friendly and richly illustrated book gathers contributions by authors internationally recognized for their outstanding laboratory research and clinical practice. This second edition includes the latest information, together with new chapters on nasal polyposis endotyping, Asian polyps, epithelial barrier in nasal polyposis, biologics of nasal polyposis, microbiome of nasal polyposis, eosinophil & nasal polyposis, nasal polyposis in children, staphylococcus aureus, superantigens and nasal polyps, and antifungal treatment in chronic sinusitis. It offers comprehensive information to help readers improve the daily management of patients affected by nasal polyposis.

The book provides basic knowledge of clinical ophthalmic signs and their application in the clinical practice of medicine. It discusses several intra and extraocular signs that help the ophthalmologists to reach a diagnosis and suggest the presence or absence of an underlying severe sight-threatening or even life-threatening disease, such as diabetes, hypertension, cardiovascular disease, hematological disorders, systemic vasculitis, rheumatological disorders, brain tumors, sarcoidosis, or infectious diseases caused by M. tuberculosis, HIV or herpes viruses. The book is divided into two sections and each chapter is dedicated to one ophthalmic sign providing its pathophysiology, significance, differential diagnosis and clues to systemic disease. Each chapter is profusely illustrated with color and black and white images, and boxes with key messages on differential diagnosis and appropriate laboratory investigations. This book serves as a one-stop resource discussing the significance of individual ophthalmic signs and their context to sensitize the physicians, both the graduates and postgraduates in training, residents and fellows in ophthalmology, family medicine and internal medicine, and practicing physicians.

This handy volume, that can also serve as an integration to the preceding work Cellular Primary Immunodeficiencies by the same editor, presents detailed state of the art knowledge on Severe Combined Immunodeficiency (SCID) with extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured according to the most recent classifications including update on the immunological synapse, as well as on bioinformatics in primary immunodeficiencies leading the reader towards the computational immunology era. Readers will also find in-depth descriptions of SCID genes and related clinical application, and aspects such as differential diagnosis, clinical management, and the role of vaccines are also addressed. The authors are recognized experts world-wide and have crafted their chapters to turn Severe Combined Immunodeficiency in a valued, compact update for immunologists, paediatricians, internists, rheumatologists, and infectious diseases specialists, that MDs and PhD students will find informative as well.

This book aims to provide more nuanced diagnostic information beyond the standard ABCDEs of melanoma diagnosis to help screen atypical presentations alongside common presentations. By providing up-to-date diagnosis, staging, and therapy information with an emphasis on dermoscopy, this unique guide provides what longer, more comprenhensive texts cannot - a succinct and concise educaitonal guide for ease of use. While there are other longer references regarding melanoma, this book attempts to provide only essential information for optimal usability across disciplines. Though small in size, the book is comprehensive in its coverage, offering chapters on staging and diagnosis while going more in depth on chapters covering melanoma in childhood and during pregnancy. Images are primarily sourced from actual patients through extensive use of the dermatoscope to get the highest definition photo available. Melanoma - From Diagnosis to Therapy is a valuable resource for practicing dermatologists and residents as well as practitioners who work in general clinical settings and patients looking for a more detailed understanding of the disease.

A key problem in medicine is that certain diseases may involve organ systems that cross the boundaries of individual specialties. For instance, a patient with scleroderma can develop myocarditis, or one with vasculitis can manifest with aortitis, which in turn can affect the function of the aortic valve. This book represents a dialogue between specialties, helping clinicians understand the implications of disease both within their own specialty and in the overlapping specialty of the case. Here leading experts from the fields of rheumatology and cardiology provide a masterclass in the care of patients with systemic illnesses that involve the immune system and the cardiovascular system.Key Features: Provides a clinical approach to the patient with cardiovascular manifestations of rheumatic disease. Details cutting-edge research with inputs from the world's leading experts. Discusses possible future directions for research and advancement.

This book examines the development and applications of system biology approaches for the prevention, diagnosis, and understanding of disease mechanisms. It explores the applications of system biology in infectious diseases, including host-pathogen interaction, and the identification of targets for new therapeutics and intervention strategies. It covers the use of system biology for understanding and treating metabolic disorders towards personalized and precision medicine. The book further discusses the systems biology approaches for understanding the mechanisms of tumor progression and designing more effective cancer therapies. The chapter also reviews the current strategies in autoimmune disease treatment and highlights the opportunity that systems biology represents for the development of better and safer treatments. Importantly, the book discusses the current state of the systems-level understanding of diseases and both the therapeutic and adverse mechanisms of drug actions usingsystem biology approaches. Cutting across the disciplines, this book is a valuable source for researchers in genetics, molecular biology, cell biology, microbiology, and biomedical sciences.​

To the non-neurologist, neurology can be one of the most intimidating fields of medicine, yet it includes many common problems faced in everyday primary care practice. Written specifically for the general clinician, Practical Approach to the Neurological Patient: A Clinician's Guide provides clear, up-to-date, and easy-to-understand guidance on commonly encountered issues, helping you take an informed approach to patients with neurological concerns. Dr. William J. Mullally and a team of expert contributing authors address headache, dizziness, stroke, pain, head trauma, and much more, making this volume an indispensable resource for primary care practitioners, internists, family practitioners, medical specialists, medical residents, nurse practitioners, physician associates, and students. - Offers concise, comprehensive content designed to help guide the primary care provider or non-neurologist on how to manage patients with common neurological conditions. - Covers timely topics such as women's neurology, neurogenetics, pain neurology, sleep disorders, dementia, and headache (including facial pain). - Includes Key Points in every chapter, MRI images that show brain lesions, figures and tables throughout, and clinical algorithms to support everyday decision making. - Features multidisciplinary input from physician authors who are contributors to the American Journal of Medicine, as well as a nurse practitioner and physician associates.

The main objective of translational health science is to concentrate on discovering healthcare products for all people where care gaps exist. This book examines the applications of translational research, identifies its difficulties, outlines its essential characteristics, considers healthcare management strategies, and examines the public's perspectives today. This book assists aspiring implementation scientists in researching this area because the discipline is still relatively young for the wide range of researchers tackling the challenge of clinical and translational science, a field dedicated to examining human health and disease, interventions, and outcomes to develop new treatment approaches, devices, and modalities to improve health. This book Edition is the most authoritative and timely resource that introduces new physiological and therapeutic processes to engage the fastest-growing scientific outcomes from academic and industrial research. The chapters in this book give insights into perspectives on the field of clinical and translational science and discuss artificial intelligence in drug development and conventional and novel clinical trial designs. There is a lot of hope that using artificial intelligence (AI) will significantly advance all facets of healthcare, from diagnosis to therapy. AI is prepared to assist medical staff with various duties, including administrative workflow, clinical documentation, patient outreach, and specialist support like image analysis, medical device automation, and patient monitoring. Some of the most important uses of AI in healthcare will be covered in this book by eminent Scientists, Academicians, and Industrial persons from both clinical and non-clinical fields.

This book covers all aspects of how various Hormonal diseases affect Skin Health. It covers essential parts of the most common Hormonal disease - Polycystic Ovarian Disease (PCOD), i.e., its Pathogenesis, investigations, and individual clinical features with their Line of management.Chapters also provide information about other common yet less discussed hormonal issues like- Diabetes, Thyroid disease, and obesity affecting the skin and what signs and symptoms should be looked for in such patients for early diagnosis and treatment.Hence, this book assists Dermatologists, Consulting Physicians, Post Graduates, and Interns in a holistic understanding and practical management of standards as well as other miscellaneous issues like Diet and Hormones and Urticaria and Hormones.

A Reedsy Discovery'Must Read'with an'A'rating from Booklife by Publisher's WeeklyDrawing on 35 years of experience in the biotechnology industry developing innovative cancer medicines, Dr. Drew N. Kelner (Ph.D. in Biochemistry from Duke University) provides an insider's view of how the astonishing new immunotherapies that are changing the lives of cancer patients came about, how they work, and how these powerful new drugs are changing the paradigm of cancer medicine from the toxic and destructive triad of “cut, burn, and poison—surgery, radiation, and chemotherapy—to the use of'living drugs'made from engineered cells, modified viruses, and other molecular marvels that target the root causes of cancer and stimulate human immunity. In Taming Cancer, Dr. Kelner sends a message of hope to cancer patients and their families the world over by presenting a lucid vision of a time when a diagnosis of metastatic cancer is no longer by default a harbinger of impending suffering and death. Written for readers interested in developing a conceptual understanding of cancer and what can be done to confront it, the book also contains extensive endnotes for those who wish to delve deeper into the science. Taming Cancer provides the information needed to understand the changing landscape of cancer medicine and how immunotherapy and other targeted treatments are optimizing cancer care.

Since the emergence of 2022's monkeypox virus (MPXV) outbreak, it has been the heading of news and research articles that MPXV is being involving non-endemic areas after about its 80-year presence in endemic areas. Efforts are concentrated on understanding how MPXV has evolved to cause an epidemic. The book provides a comprehensive compendium of chapters on poxviruses in different domains. It concludes that the main problem we should deal with is not to address how MPXV has overcome the distance between non-endemic and endemic areas, but it is the non-cooperativity of logistics, research, and science in managing poxviruses'outbreaks.

The book aims to be a handy compendium to the very voluminous texts of gastroenterology and hepatology existing in the knowledge market and provides the reader with an easy understanding of the bench knowledge (basic sciences) as they apply to bedside practice (clinical gastroenterology). With introduction and contributions from Prof Eamon Quigley, Former president of World Gastroenterology Organization and American College of Gastroenterology, the book covers the recent advances in the basic sciences that form an important pillar of the knowledge, thereby linking basic sciences such as anatomy, physiology, biochemistry, molecular medicine, etc. to clinical conditions, diseases and new therapeutic approaches in gastroenterology and hepatology. The book is written in a simple easy to read format, with a lot of diagrams and flowcharts, making it a handy guide. It also discusses in-depth about very common clinical conditions encountered in hospital settings such as ulcerative colitis, pseudomembranous colitis, colonic cancer, amebiasis, and various other syndromes and diseases. This book is a useful read for fellows and trainees in Gastroenterology and Hepatology, as well as gastroenterologists, hepatologists and physicians interested in digestive disorders.

This textbook is intended to fill a perceived gap in this domain of a holistic approach to all pleural pathologies. All the chapters of this book are written by specialists; dealing with pleural pathology pertaining to specific diseases in their specialty.

Both volumes sold as a combined set for a one-time purchase! Older adults represent the most rapidly growing demographic in the U.S. and in many developed countries around the world. The field of geriatric medicine is still relatively young, and is only recently seeing a significant increase in peer reviewed literature. Medicare and Medicaid expenditures related to older adults are nearly a trillion dollars/year in the US. How our healthcare system cares for older adults, and how those older adults navigate an increasingly complex system, is of the utmost importance. According to the Institute of Medicine, physicians and other healthcare professionals receive an inadequate amount of training in geriatric medicine. Geriatric medicine is based on the concept of delivering person centered care with a focus on function and quality of life. It is essential that physicians, nurse practitioners, physician assistants, pharmacists, social workers and other health care professionals all be knowledgeable about thegeriatric approach to care. Geriatric medicine varies from most other fields in medicine. While many specialties function on the basis of evidence-based literature, geriatricians and other clinicians caring for older adults must integrate relatively limited evidence with variable physiological changes and complex psychosocial determinants. Geriatricians are used to caring for 90 year olds with multiple chronic illnesses. Their variable physiology leads to uncertain responses to pharmacotherapy, and their personal goals and wishes need to be incorporated into any plan of care. Practicing geriatric medicine requires the ability to see patterns. But it goes one step further, as the rules are constantly in flux. Every patient is an individual with particular needs and goals. In order to provide true person centered care to older adults, one has to incorporate these factors into the decision making process. The proposed handbookis designed to present a comprehensive and state-of the-art update that incorporates existing literature with clinical experience. Basic science and the physiology of aging create a background, but are not the main focus. This is because every chapter has been written through the lens of “person centered care.” This book is about focusing on what matters to the person, and how that is not always about pathology and physiology. The reader generally will not find simple solutions to symptoms, diseases and syndromes. In fact, the key to caring for geriatric patients is the ability to think both critically and divergently at the same time. Geriatrics encompasses multiple disciplines and spans all of the subspecialties. It requires knowledge of working within an interdisciplinary team. It requires an appreciation of how quality of life varies with each individual and creates treatment and care plans that also vary. And most of all, it requires a firm commitment to first learning who the person is so that all of the necessary data can be analyzed and integrated into a true person centered plan of care. This book aims to serve as an unparalleled resource for meeting these challenges. Updated and revised from the previous edition, this text features over 40 new peer-reviewed chapters, new references, and a wide array of useful new tools that are updated on a regular basis by interdisciplinary and interprofessional experts in geriatric medicine.

Written by experts in the field, Precision Molecular Pathology of Aggressive B-Cell Lymphomas contains the most recent revisions from the 5th Edition WHO and 2022 International Consensus Classification diagnostic categories and serves as an important resource for trainees, pathologists, haematologist/oncologists, other clinicians involved in lymphoma care and lymphoma researchers. It provides a comprehensive yet concise synthesis of emerging molecular advances that inform patient care and improve understanding of disease mechanisms. In addition, it provides the necessary background to how molecular techniques are performed to enable the reader to better interpret and critically evaluate relevant and emerging data. As part of the Molecular Pathology Library series, this book focuses specifically on aggressive B-cell lymphomas given the increasing relevance of molecular data for diagnosis and treatment of these disorders. This evidence-based text contains 25 chapters and is divided into 5 parts. Part 1 provides a brief history and background of aggressive B-cell lymphomas. Landmark events in their classification and treatment are given in order to place the substantial advances in the field in context. Part 2 reviews molecular pathology methods, including the increasing use of next generation sequencing techniques in clinical practice. Parts 3 and 4 focus on individual subtypes of aggressive B-cell lymphoma, including a summary of the diagnostic criteria and key pathologic and clinical features for each entity. Finally, Part 5 focuses on emerging molecular technologies that may significantly impact clinical practice.

From the latest vaccination evidence, recommendations, and protocols... to new vaccine development and the use of vaccines in reducing disease, Plotkin's Vaccines, 8th Edition, covers every aspect of vaccination. Now completely revised and updated from cover to cover, this award-winning text continues to provide reliable information from global authorities, offering a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as'an indispensable guide to the enhancement of the well-being of our world,'Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Contains all-new chapters on COVID-19, vaccine hesitancy, and non-specific effects of vaccines, as well as significantly revised content on new vaccine technologies such as mRNA vaccines, emerging vaccines, and technologies to improve immunization. - Presents exciting new data on evolution of adjuvants across the centuries, dengue vaccines, human papillomavirus vaccines, respiratory syncytial virus vaccines, tuberculosis vaccines, and zoster vaccines. - Provides up-to-date, authoritative information on vaccine production, available preparations, efficacy and safety, and recommendations for vaccine use, with rationales and data on the impact of vaccination programs on morbidity and mortality. - Provides complete coverage of each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, as well as epidemiology and public health and regulatory issues. - Keeps you up to date with information on each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Covers vaccine-preventable diseases, vaccine science, and licensed vaccine products, as well as product technologies and global regulatory and public health issues. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Der Begriff menschliches Mikrobiom hat sowohl in der Wissenschaft als auch in der Öffentlichkeit in letzter Zeit große Aufmerksamkeit gefunden. Das Buch führt den aktuellen Forschungsstand des gastrointestinalen Mikrobioms und seinen Einfluss auf eine Vielzahl an Erkrankungen zusammen und benennt neue therapeutische Möglichkeiten, die sich aus den Erkenntnissen ergeben. Internisten, Fachärzte anderer Disziplinen und andere interessierte Fachgruppen erhalten einen Überblick neuer wissenschaftlicher Konzepte. Namhafte Experten aus der Mikrobiom-Forschung erläutern diagnostische und therapeutische Ansätze für die Themenfelder der onkologischen Erkrankungen, Adipositas, Infektionserkrankungen, Neurodegenerative Erkrankungen wie auch den gastrointestinalen funktionellen Krankheitsbildern wie Reizdarmsyndrom oder FD. Eine gute Orientierung bietet das Buch bei der wachsenden Zahl von Studien - unter funktionellen Gesichtspunkten und hinsichtlich von Einsatzmöglichkeiten der zunehmenden Erkenntnisse für die Diagnostik, Prophylaxe und Therapie von Erkrankungen. Es werden Zusammenhänge zwischen Gesundheit und Krankheit und mikrobiellen Konsortien sowie Funktions-Zuschreibungen an bakterielle Spezies und ihre metabolischen Charakteristika vorgenommen. Weiterhin wird die Funktion kommensaler bakterieller Gemeinschaften und der Einfluss dysbiotischer Veränderungen auf die Gesundheit erläutert. Auch die Einflüsse des Mikrobioms auf die Wirksamkeit pharmakologischer Interventionen (z.B. Checkpointinhibitoren) werden als neues relevantes Feld der Mikrobiom-Forschung besprochen.

This book delves into the various aspects of the renin-angiotensin-aldosterone system (RAAS) and its role in cardiovascular disorders. It explores the use of anti-hypertensive agents, with a focus on (ACE) angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs). The chapters cover topics such as the preferred use of ACE inhibitors over ARBs in high-risk patients, the impact of these agents on insulin resistance, their role in acute heart failure and peripheral artery disease, and their immunomodulatory activity in hypertensive patients. Additionally, the book examines the role of ACE inhibitors and ARBs in COVID-19 patients and provides insights into recent trends in managing hypertension through RAAS inhibition. It serves as a valuable resource for researchers, clinicians, and healthcare professionals involved in the field of cardiovascular medicine.

The second edition of this important textbook covers all aspects of neuroendocrine tumors (NETs), from epidemiology, pathological classification and evaluation, and molecular biology through to diagnostic imaging methods and therapeutic options, including the latest targeted therapies and immunotherapies. Readers will find individual discussion of each of the various types of NET: gastrointestinal, lung, and pancreatic tumors such as insulinomas, gastrinomas, glucagonomas, VIPomas, somatostatinomas, PPomas, and non-functioning pancreatic NETs, as well as medullary thyroid carcinomas, pheochromocytomas, paragangliomas, etc. In addition to NETs, endocrine tumors such as thyroid tumors and adrenocortical tumors are also covered. The contributing authors are internationally recognized experts who bring a wealth of science and experience to the subject. This book will be an invaluable source of information for practicing medical oncologists, surgeons, endocrinologists, gastroenterologists, and pathologists as well as for trainees in these fields.

This book provides essential information on the epidemiology, diagnosis and management of common and some rare infections in travellers. It will equip readers with key knowledge on clinically important emerging and re-emerging infections caused by wide variety of bacteria, viruses and parasites. The coverage ranges from influenza, hepatitis, malaria and tuberculosis to Ebola virus disease, Lassa fever, Crimean Congo haemorrhagic fever, dengue, Zika virus infection and many other important diseases. The emergence and spread of antimicrobial-resistant microorganisms is discussed, and practical advice is included regarding disease prevention in travellers and humanitarian aid workers. Other generic chapters address the clinical approach to fever in the returning traveller, and preparedness and response to emerging infectious diseases. This comprehensive, up-to-date book will be an excellent source of information and guidance for all clinicians and researchers with an interest in infectious diseases, microbiology, epidemiology, and travel medicine.

Lung transplantation is a successful therapeutic option for patients with end-stage respiratory failure. Although the clinical outcomes of this procedure have been constantly improving, the care of patients undergoing lung transplantation is still a striking challenge for the entire team involved in the process. The complexity of a clinical lung transplant program requires a trained, multi-specialist team and continuing technical update. Technology provides exciting new opportunities for the improvement of clinical outcomes. This text provides a comprehensive, practical and up-to-date insight into clinical lung transplantation. It moves along the pre-, intra-, and post-operative phases of transplantation. It explores the most relevant surgical, medical and immunological concepts of this field. The content focuses not only on the technical, scientific and medical aspects of lung transplantation, but also on the administrative, regulatory and nursing topics of running a lung transplant program. Rather than presenting purely theoretical chapters, the text sets the focus on clinical dilemmas and practical issues involving all the professionals who actively run a lung transplant program. The reader will be able to access the book for reference on any topic related to clinical care in lung transplantation. This text is intended as a practical resource for surgeons, physicians and health professionals involved in lung transplantation or in setting up a lung transplant program. All chapters are written by experts in their fields and will include the most up to date scientific and clinical information. The overall intent of this publication is to assist the health care provider in all the daily aspects of lung transplantation and to offer a modern, practical source of suggestions and answers.

This book covers contemporary essays by opinion leaders on crucial topics in dermatology that are not readily available in other textbooks and journals. The essays are written in an unconventional style compared to other textbook styles. Each chapter is authored by a globally renowned expert in that field.The book focuses on artificial intelligence in dermatology, placebo and nocebo in dermatology, mind and skin diseases, unconventional/holistic views on skin aging, evidence-informed dermatology, procedural dermatology, investigative dermatology, lasers and light sources in dermatology, skin in rheumatologic diseases, immunology of the skin, live imaging techniques in dermatology, and so on. The book will help specialists look at the subject from an entirely different perspective and understand how dermatology is evolving in the 21st century. A wide range of dermatology topics is covered, providing a snapshot of contemporary dermatology and the dermatology of the future. It promises to be a delightful journey from basic science to translational science to clinical science. This book will be Intellectually stimulating for dermatology trainees, practitioners, and academicians.

This book presents the recent developments in immunomodulatory biomaterials for cell-based therapies in various diseases, including diabetes, cancer, cardiovascular disease, and bone regeneration. The authors first cover the fundamentals of conventional immunology and immunomodulation, before focusing on the history, advantages, and challenges of cell therapies. Biological cell therapy has gained immense attention for various diseases due to unique advantages it has over chemical drugs regarding cost, ease of production, toxicity, and therapeutic efficacy. However, these cell-based therapies need an inert delivery system that can locally deliver cells and minimally elicit foreign body response. The book discusses the foreign body response to the immunomodulatory biomaterials as well as the current and future strategies for potential mitigation of considerable immune responses toward immunomodulatory biomaterials and devices.

This book is the first authoritative and comprehensive text dedicated to the understanding of how cholesterol triggers vascular inflammation and mechanical injury that leads to heart attacks, strokes as well as other organ and tissue pathology. It includes chapters on the background of cholesterol crystal formation and methods for their detection as well as a description of the physiochemical transformation of metastable ‘liquid'cholesterol to a solid flat plate crystalloid within the cellular and extracellular environment resulting in volume expansion. Chapters also discusses cholesterol crystals and other crystalloid molecules found in atherosclerotic plaque. In addition, the book examines how cholesterol crystals can induce similar injurious processes in other organs including the retina of the eye to cause blindness, in solid cancers causing further tumor growth and in the brain of patients with Alzheimer's. And lastly, the book addresses various potential therapeutics that disrupt the physiochemical transformation of cholesterol from a liquid to a solid, inhibit its role in triggering inflammation and tissue injury while ushering a path towards targeted therapies.Cholesterol Crystals in Atherosclerosis and Other Related Diseases will be of interest to cardiologists as well as individuals in various fields of science including crystallography, basic and clinical imaging, cardiac oncology, and drug discovery.

This book gives the reader an appropriate background for diagnosing and treating patients with vestibular disorders. Most causes of vertigo can be effectively treated, and there have been major advancements in both vertigo diagnosis and treatment in recent years. Unfortunately for many practitioners, modern training in the management of vertigo was not included as part of their residency. The major barrier to effective treatment in most patients seems to be lack of awareness of the correct diagnoses and treatment options on the part of providers. This book directly addresses that knowledge gap.The text is divided into 16 chapters. The initial chapters are an overview of normal vestibular anatomy, function, and testing. The next section of the book builds on these chapters to discuss the treatment of specific disorders like Ménière's disease, vestibular neuritis, benign paroxysmal positional vertigo, and third mobile window conditions. The connectionbetween vestibular disorders and psychiatric conditions such as anxiety and depression is discussed. Recent advancements in the treatment of vestibular disorders are covered with chapters on vestibular physical therapy and vestibular implantation. The book closes with a discussion of aging and the vestibular system.Disorders of the Vestibular System is an excellent guide to this rapidly evolving field and will be of great use to physicians in otolaryngology, neurology, and general practice who are likely to encounter patients with dizziness and vertigo.

This is an original work dedicated to an important and current topic in nephrology: organ crosstalk in acute renal injury. Acute kidney injury is a prevalent and serious syndrome. The related mortality to this syndrome has not been significantly reduced in the last decades despite the advances in renal replacement therapy technology. For this reason, a new approach to obtain an effective treatment is urgently needed. The organ crosstalk perspective could be useful in order to achieve this objective since it implies a very early acute kidney injury diagnose and treatment. This book includes a comprehensive review of the organ crosstalk perspective in acute kidney injury. Organized in two parts, the chapters in the first part present general subjects as an introduction to analysing the crosstalk concept. These chapters give an overview of the concepts of biosemiotics, hormones, neurotransmitters, cytokines, signalling and adhesion molecules, organ intercommunication, and epigenetics. The second part gathers chapters on the different kidney crosstalk, such as brain, lung, heart, liver, gut, and placenta. Finally, there is a chapter dedicated to the influence of renal replacement treatment on kidney crosstalk. Since acute kidney injury is a topic of interest to many health professionals, this work will be a useful resource to general practitioners, internal medicine physicians, geriatricians, nephrologists, critical care therapists, immunologists, and also biologists and bioengineers.

This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called “magic bullet” (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.

The first volume of the book-Emerging Human Viral diseases presents pathogenesis, diagnostics, and therapeutic strategies against viral respiratory and hemorrhagic fever diseases. The initial chapter discusses the underlying factors contributing to the emergence of these viral diseases. The subsequent chapters introduce structure, composition, and organization of viral genomes, and provide insight into function of important viral proteins. It also discusses the host factors that influence the outcome of viral infection and host immune response to the infections caused by these viruses. The book also discusses clinical manifestation and strategies for the prevention of virus diseases and highlights the recent technical advances in the diagnosis of virus diseases, prevention, and control strategies for viral infections. This timely book offers valuable resource for the scientists working in the field of emerging viral infections and those involved in preventing, controlling, and managing viral diseases.

The purpose of this book is to outline the topics that are critical in the dermatological approach to patients with cancer. This purpose will be accomplished by discussing the value of a multidisciplinary approach, and case examples will be used, including some from the Hospital Sírio-Libanês, a pioneering institution in the treatment of cancer. In all, the book will present and discuss the best global evidence for the dermatologic care of patients with cancer, skin cancer, and solid organ- and bone-marrow-transplanted patients. The clinical, surgical, pathologic, imaging, radiotherapy, oncology and palliative care aspects of the dermatologic care of cancer patients will be covered. The book will also discuss subjects such as genetics, biology, evidence-based medicine, and new diagnostic methods and tools such as dermoscopy and confocal microscopy. Chapters will be based on the following key areas: educating clinicians on how to prevent skin cancer in patients, screening and counseling, diagnosis and treatment of pigmented lesions, melanoma and nonmelanoma skin cancer, cutaneous lymphomas, sarcomas, leukemic and lymphomatous infiltrations, cutaneous metastases, cutaneous paraneoplasic manifestations and cutaneous adverse reactions to chemotherapy and radiation treatment. The primary audiences are dermatologists, oncologists, radioncologists and oncologic surgeons. The secondary audience is residents in these fields. The goal is to prepare and update all specialists on this important clinical and research area.

The second edition comprehensively reviews the wide field of rare pulmonary diseases. Issues such as less common diseases affecting the airways, systematic disorders with lung involvement, interstitial lung diseases, and many other orphan conditions of the lungs are explored in this book. The progress and advances made in the field and the limited number of patients presenting each condition makes it very difficult for clinicians to be up-to-date in this field. Readers will discover how to diagnose and manage these rare orphan diseases. Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease is a practical, informative book written by a team of international authors with much experience in rare pulmonary diseases Orphan Lung Diseases: A Clinical Guide to Rare Lung Disease, second edition provides synthesized and easily accessible information about the main orphan lung diseases, to aid clinicians in charge of patients with rare disease,or who consider the diagnosis of a rare disease in their patient. It is a practical, informative guide written by a team of international experienced authors in rare pulmonary diseases.

This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.