Search

This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artificial intelligence can improve the precision of treatments. The advent and basis of predictive cancer care, the role of pathologists in translational cancer research, the analysis of cancer samples, the management of biopsy results, and the accuracy of biopsy results are also discussed. Precision Cancer Medicine: Role of the Pathologist details how pathologists can use the latest biomarkers and apply artificial intelligence technology in cancer diagnosis and management. It is also relevant to oncologists and medical practitioners involved in cancer management seeking an up-to-date resource on the topic.

This book introduces recent topics regarding carcinogenesis, including manifold findings of cell proliferation biology, abnormal cell division, pathophysiology, diagnosis, prevention and treatment implicated in the fields of cancer. Carcinogenesis is a multistep process initiated by external stimuli that lead to genetic changes in normal cells or stem cells, resulting in proliferation, apoptosis, dysplasia and neoplasia. The expression, post-translational processing, and targeting of the gene products are frequently altered in transformed and malignant cells. Currently, prognosis of advanced cancer remains poor in spite of the development of novel therapeutic strategies. Improved knowledge of the oncogenic processes and signaling pathways that regulate tumor cell proliferation, differentiation, angiogenesis, invasion and metastatis has led to the identification of several potential therapeutic targets, which have driven the development of molecularly targeted therapies. The target is “drugable”, as an enzyme (kinase) or cell surface molecule (membrane-bound receptors) that can be easily screened for small-molecule inhibitors or targeted by a specific antibody. New perspectives in cancer treatment have appeared with the advent of microRNAs, a novel class of noncoding small RNAs. Moreover, identification of the genes that are differentially expressed between sensitive and resistant cancer cells for chemotherapy and radiation is important in the ability to predict the clinical effectiveness of therapy and develop new therapeutic tools. This book provides recently discovered information concerning cancer biology as well as translational treatment for cancer patients.

The book Psychoneurocybernetic Conquest of Carcinogenesis and Cancers is written to be understood by the informed layman as well as by scientists. It should be of special interest to physicians, health-care givers and laymen who want to know about the latest knowledge concerning the true cause of all cancers and their prevention, diagnosis and modern therapy. It will surely inform and entertain anyone who cares about ethics in medicine or the funding of medical research, including references to original scientific and popular literature. According to general (not only medical) knowledge, based upon personal experiences in conservative, surgical, thermo- and radiotherapy of neoplasms over many years, the authors have presented the dissipative nature of cancer so that everyone could understand the neoplastic diseases, the modern rules of psycho-oncology and the primary significance of one's own lifestyle in the formation and progress of cancer along with importance of caring about the environment inhabited by people. They have summarized the public reactions to cancer and infertility in relation to the historic discovery of natural psychoneurocybernetic cause of cancer, mathematical interpretation of its cause, obstetrical prevention of human cancers and psycho-neuro-endocrine therapy of diseases, especially caused by baneful information.

With over two hundred types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies. Bringing together the state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate research goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. Readers are provided with a realistic view of what is known and what is yet to be uncovered on the aberrations in the fundamental biological processes, deregulation of major signaling networks, alterations in major cancers and the strategies for using the scientific knowledge for effective diagnosis, prognosis and drug discovery to improve public health.

Chemical Induction Of Cancer: Structural Bases and Biological Mechanisms Volume IIA deals with the organic and biochemical principles behind cancer. This volume includes Part III of the work, which covers structure-activity relationships of chemical carcinogens, the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Under this is Chapter 5, which tackles conjugated aromatic systems. The text is recommended for doctors, organic chemists, and biochemists with an advanced knowledge in biochemistry and organic chemistry and would like to know more the biochemical processes of cancer.

The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard to its biosynthesis, inhibition of synthesis, and development of resistance to inhibitors. The book further tackles the biochemical mechanisms of chemical carcinogenesis; the oncogenic viruses; and the molecular correlation concept. The text also demonstrates phenotypic variability as a manifestation of translational control; and plasmacytomas. Molecular biologists, virologists, pathologists, cell biologists, oncologists, pharmacologists, and students taking related courses will find the book useful.

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins. The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and related compounds. The structure-activity relationships, metabolism, and environmental significance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and related compounds thiocarbonyl compounds are also encompassed. The book further tackles the structure-activity relationships, metabolism, and environmental significance if fatty acids, detergents, and other surfactants with oncogenic potential. The text then looks into the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Chemists, geneticists, and those involved in cancer research will find the book invaluable.