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Ob damals im Studium oder heute bei der Vorbereitung von Vorträgen, ob bei der wissenschaftlichen Arbeit oder in Diskussionen zur Funktionsweise des Gehirn- immer und immer wieder kam ich an einen Punkt, an dem ich kurz und knapp Informationen zu einer Struktur haben wollte. In den gängigen Lexika fehlen die meisten Termini, und über die Lehr-und Handbücher oder über die Originalarbeiten ist der Zugriff recht langwierig. Kurz und gut: ein Glossar neuroanatomischer und neurofunktionaler Termini mußte her. In langjähriger Arbeit entstand nun das vorliegende Glossar, das all jenen helfen soll, die'mal eben'Informationen zu Strukturen des Gehirns nachschlagen wollen. Dabei war es nicht das Ziel, aktuellste Forschungsergebnisse und -diskussionen zu dokumentieren, sondern solide Grundinformationen zusammenzustellen, die helfen, die entsprechende Struktur schnell und effizient in einen Gesamtzusammenhang einzubetten. In diesem Sinne ist das vorliegende Glossar zu verstehen. Ein herzlicher Dank geht an folgende Personen, die alle einen Teil des Glossars tragen: an Herrn Dr. Lange für die Initiierung des Buches und die reibungsfreie Betreuung, an Frau Wilbertz für das effiziente Vorantreiben der Produktion, an Frau Dr. Harder für das Korrekturlesen und die wertvolle Zuarbeit, an meine Familie für das treue Warten -und, last but not least, an die Firma iAS (www.brainmedia.de) für die Abbildung auf der Titelseite.

This dictionary is an ideal reference for researchers and students, providing information on all structures related to neuroanatomy. Its standardized entries are sorted in alphabetical order to guarantee quick and easy access. The Dictionary of Human Neuroanatomy is based on the data presented in the InterBRAIN CD-ROM and lists approximately 1,000 neuroanatomical terms.

The topographical and functional architecture of the human brain is highly complex. This stereoscopic atlas provides new insight into the human brain. The illustrations in this stereoscopic atlas have been developed using a new 3D-visualization computer model. In combination with the CD-ROM, which contains all 173 illustrations as rotatable 3D models, this innovative atlas provides a new conception of spatial structures. It has never been so easy to understand the architecture of the human brain!

The development of a comprehensive vaccine against Neisseria meningitidis, the causative agent of meningococcal disease, has remained elusive because of bacterial diversity and immunologic evasion. In Meningococcal Vaccines: Methods and Protocols, Andrew Pollard and Martin Maiden have assembled an impressive collection of the latest molecular and cellular techniques for the development, evaluation, and implementation of vaccines to be used against this dreaded disease. The contributors-leading scientists, clinicians, and public health physicians-describe in detail the many approaches to vaccine design, as well as the assessment of immune response to vaccine candidates and novel vaccine formulations. They also present as a test case the recent implementation of a new meningococcal vaccine in the United Kingdom. A companion volume, Meningococcal Disease: Methods and Protocols, contains detailed methods for diagnostic microbiology, bacterial characterization, epidemiology, host-pathogen interactions, and clinical studies. Timely and comprehensive, Meningococcal Vaccines: Methods and Protocols provides the scientist, public health physician, epidemiologist, clinical microbiologist, and clinician with the essential tools to lay bare the secrets of the meningococcus and to develop, evaluate, and implement successful new meningococcal vaccines.

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

Highly practical and comprehensive, this book provides a multimodal framework for helping patients with acquired brain injuries to identify and achieve meaningful functional goals in the home and community. In a convenient large-size format, the volume features rich case examples and interdisciplinary tools and strategies. Post-acute cognitive, physical, communication, emotional, vocational, interpersonal, family, and quality-of-life domains are all addressed, using state-of-the-art restorative and compensatory approaches. Coverage includes both individual and group therapies. Fifty reproducible forms and handouts can be photocopied from the book or downloaded from the companion website. The website also features a supplemental chapter on efficacy and outcomes research in neurorehabilitation, appendices with helpful resources, color versions of selected figures, and more.

Multiple Sclerosis (MS) is an inflammatory autoimmune disease affecting the brain and spinal cord. Despite significant advances in treatment modalities the prognosis of this patient population is still poor. New Updates on Clinical Aspects of Multiple Sclerosis reviews the clinical guidelines for diagnosis and treatment management for both pediatric and adult patients with Multiple sclerosis (MS). Multiple chapters present the various subtypes of MS in a case-based format, providing readers with the presentation of differential diagnosis. This book will also review the advancements in methods of assessing demyelinating plaques including, 7T MRI, DTI, PET, and MR spectroscopy. Multi-contributed, this book will become the essential guide for anyone in the field of MSExplores the practical applications of optical coherence tomography (OCT) and OCT angiography (OCTA) in assessing MS.Delves into utilizing advanced imaging modalities and corresponding radiological findings for the diagnosis and monitoring. Includes cutting-edge technologies: 7 Tesla (7T) magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), positron emission tomography (PET), and magnetic resonance spectroscopy (MR spectroscopy).

This comprehensive review covers the full and latest array of interventional techniques for managing chronic pain. Chapters are grouped by specific treatment modalities that include spinal interventional techniques, non-spinal and peripheral nerve blocks, sympathetic interventional techniques, soft tissue and joint injections, and implantables. This second edition features new chapters covering challenges with opioid therapy, impact of COVID-19, and spinal interventional techniques.Practical step-by-step and evidence-based guidance is given to each approach in order to improve the clinician's understanding. Innovative and timely, Essentials of Interventional Techniques in Managing Chronic Pain is a critical resource for anesthesiologists, neurologists, and rehabilitation and pain physicians.

This volume is an accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system (CNS). Chapters cover the major RNA viruses, their impact on the CNS, and the similarities and differences in pathological outcomes that can be observed. Neuroscientists, be they students, researchers, or clinicians, will benefit from the timely coverage provided.Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers can use the book to understand clearly the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of the human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell type-specific defects affect brain function and cause poor clinical outcomes.The book is aimed primarily at neuroscience students and postgraduates wishing to learn about virology and professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed; however, readers across the disciplines of science, technology, engineering, and mathematics will find this topical and timely publication of value.

Das Praxisbuch der Neurorehabilitation…… komplett aktualisiert und überarbeitet: Das große Praxisbuch bietet Grundlagen- und Praxiswissen, detailliert, kritisch, verständlich und an den Bedürfnissen der Patienten orientiert – ein rundum alltagstaugliches Arbeitsbuch für Teams, ein Lehrbuch für die Aus- und Weiterbildung. Mit neuen Kapiteln u.a. zu Telerehabilitation und der Umsetzung spezieller Therapieformen wie Virtual Reality, musikgestützte Therapie, Natur und Tiere.Umfassend: Mit ausführlicher Darstellung der Grundlagen und der Tätigkeitsfelder, beginnend von der Behandlung auf der Stroke Unit bis hin zur Rückkehr in Familie und Beruf.Interdisziplinär: Die gemeinsame Ausbildungs ​​– und Arbeitsgrundlage für alle Berufsgruppen, die in interdisziplinären Teams zusammenarbeiten: Ärzte, Pflegekräfte, Physiotherapeuten, Ergotherapeuten, Logopäden, Neuropsychologen, Sozialpädagogen, Musiktherapeuten u.a.Aktuell: Wissenschaftlich, evidenzbasiert, durchgängig mit bio-psycho-sozialer Orientierung und von den Prinzipien der ICF (Internationale Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit) geleitet.Kompetent: Fundiertes Fachwissen aus langjähriger Erfahrung, vermittelt von über 50 renommierten internationalen Autoren (aus Deutschland, Schweiz, Großbritannien, Finnland, USA).Informativ: Auch mit Reflexionen über Themen wie „Kontextsensitive Neurorehabilitation“ „Teamarbeit und Zielsetzung“, „Sexualität“, „ Identität und Biografie“, „Holistische neuropsychologische Rehabilitation“.Leserfreundlich: Leicht zugänglich mitEinheitlicher Aufbau der Kapiteloptischer Textstrukturierung: mit Trailers, Praxistipps, Übersichtsboxen, Exkursen („Näher betrachtet“) und mehr…

The fifth addition of this classic text that focuses on the diabetic foot continues the tradition of the previous four editions. More specifically, it includes contributions from a distinguished panel of clinicians and researchers, who have either participated in previous editions or are new, who provide up-to-date information on the pathophysiology and management of diabetic foot ulceration. As with the previous editions, it is divided into three sections: the first part focuses on clinical features and diagnosis; the second on pathophysiology; and the third on the management of diabetic foot problems. The main emphasis of the clinical part is on the multidisciplinary approach that has been mainly developed by the world-renowned Joslin-Beth Israel Deaconess Foot Center, which pioneered the management of diabetic lower extremity problems. Also like previous editions, the author panel includes diabetologists, podiatrists, vascular surgeons, infectious disease specialists,orthotists, plastic and orthopedic surgeons, the majority of whom work at the Joslin-Beth Israel Deaconess Foot Center. In addition, the fifth edition not only describes the state-of-the-art current methods in clinical practice but also includes a thorough update of all research progress during the last five years. This updated edition of this timely text will be of significant value to all physicians and researchers with interest in a comprehensive understanding of the diabetic foot.

How to Build a Human Brain takes a developmental approach to understanding brain structure and function. It guides readers through the evolution of the human brain, from its cellular building blocks, up to hind brain structures and functions, and through to neocortex and associated functions. In doing so, it enables students to develop a comprehensive knowledge of the relationship between brain networks and functions, neural underpinnings of functional problems seen after neuropathology, and neuroanatomy.Written in an engaging style, each chapter follows a blueprint format with subsections on issues like'damage and repair'and'faulty wiring'as the brain is ‘built'across the course of the book. The author includes illustrative case studies and entertaining fast fact boxes to highlight the real-word relevance of each brain structure being examined. This textbook offers an accessible reference for students of neuroscience, cognitive neuroscience, neuropsychology,and biological psychology.

The Oxford Textbook of Neurohaematology is a single source of knowledge on the diverse neurological conditions associated with malignant and classical haematological diseases. The book covers the full range of haematological diseases, both malignant and classical, that impact the central, peripheral, and autonomic nervous systems. The book is divided into three sections. In the first section, neurological conditions associated with malignant haematological diseases are presented. This section begins with chapters on primary haematological malignancies of the nervous system including primary central nervous system lymphomas, vitreoretinal lymphoma, and other rare primary malignancies such as Hodgkin disease and lymphoproliferative disorders. Next, a chapter on histiocytic tumours of the central nervous system presents the neurological conditions associated with the Langerhans and non-Langerhans histiocytoses. This is followed by chapters covering the neurological complications of systemic myeloid and lymphoid malignancies. The second section of the book covers neurological complications of the treatments used in the management of haematological malignancies such as chemotherapy, radiation, and immunotherapy including chimeric antigen receptor T cells. The third and final section of the book features chapters on the neurological complications associated with classical haematological diseases including disorders of red blood cells (e.g., sickle cell anaemia), disorders of platelets and coagulation (e.g., immune thrombocytopenia), and disorders of white blood cells (e.g., hyperviscosity syndrome). Edited by leading authorities in the field, this book will serve as a useful resource for neurologists, haematologists, and oncologists, as well as for subspecialists and allied health professionals involved in the management of haematological diseases and their neurological manifestations.

Dieses Buch beleuchtet die Wirkungen von Musik auf Gesundheit, Wohlbefinden und Lebensqualität aus der Sicht interdisziplinärer, musikwissenschaftlicher und medizinischer Forschung. Hochrangige Expert•innen aus vielfältigen Fachgebieten stellen die wissenschaftlichen Grundlagen für medizinische, therapeutische, pädagogische und andere Anwendung vor. Inhaltlich spannt es den Bogen von den psychophysiologischen Grundlagen emotionaler Wirkungen des Musikhörens bis hin zu musikmedizinischen und -therapeutischen Interventionen. Musik erweist sich vielfach als äußerst wirksame, nahezu nebenwirkungsfreie und vergleichsweise kostengünstige unterstützende Strategie für Prävention, Therapie und Rehabilitation in vielen medizinischen Fachbereichen.Ein breites Spektrum musikalischer Aktivitäten einschließlich Musikhören, Laienmusizieren, Chorsingen, Tanzen und verschiedene Formen musiktherapeutischer Strategien steht den Erfordernissen unterschiedlicher Zielgruppen, individuellen Unterschieden, Vorlieben und kulturellen Hintergründen gegenüber. Die Neuauflage wurde aktualisiert und mit Inhalten zu COVID 19 und einer neuen Sektion zu gesundheitlichen Belastungen durch Musik erweitert.Ärzt•innen und medizinisches Personal in Sozial- und Pflegeberufen erhalten profunde Informationen über Chancen und Grenzen musikbezogener Angebote. Die Kapitel eignen sich ebenso als Einstiege für Wissenschaftler•innen zahlreicher Fachrichtungen aus Sozial-, Natur- und Geisteswissenschaft.

This official textbook of the Society of Neurocritical Care (SNCC) comprises a comprehensive review of all possible neurologic conditions that one may encounter in the practice of neuro-intensive care. It covers various topics, from the history and origin of neuro-intensive care to psychological and nursing care. Neurocritical care is the intensive care management of patients with life-threatening neurological and neurosurgical illnesses such as massive stroke, bleeding in or around the brain (subarachnoid hemorrhage, intracerebral hemorrhage, subdural hemorrhage, intraventricular hemorrhage), brain tumors, brain trauma, status epilepticus, nerve and muscle diseases (myasthenia gravis, Guillain-Barre Syndrome), spinal cord disorders and the cardiopulmonary complications of brain injury. Neurocritical care units specialize in managing the unique needs of such critically ill patients. The textbook is divided into many sections. Chapters discuss issues related to palliative care and describe some of the commonly performed procedures in the neuro-intensive care unit as well. It provides a straightforward and systematic approach to various clinical problems encountered during intensive care management of neurologic patients. It includes a separate section on special considerations in neurocritical care. The book includes ample figures, flowcharts and algorithms. The textbook is a valuable resource for residents, fellows and trainees in neuroanesthesia, neurointensive care, critical care, and anesthesia. It serves as a quick guide to all intensivists managing neurosurgical patients. It is also helpful for general intensivists who occasionally manages neurologic patients.

This second edition updates established evidence for contemporary management of ischemic stroke. Therapeutics for acute management, secondary prevention, recovery, rehabilitation, asymptomatic cerebral ischemia, special populations, and implementation of stroke systems of care are all discussed. Chapters are authored by leading academicians from around the world with real-world clinical practice experience, and comprise the scientific rationale and expert consensus recommendations, which underlie prevailing (and possibly future) therapeutic strategies for managing ischemic cerebrovascular disease. New chapter topics include neuroprotectants, treatment of the oldest old, brain-computer interfaces, disparities, and the global burden. The specialist or general practitioner will gain critical knowledge in stroke management, current clinical challenges and promising new therapies under investigation.

This revised, expanded third edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics. Each chapter now contains teaching/training MCQs to help with retention of information learnt from each chapter and this will be of considerable use to those training or about to the examined inthe field of inherited stroke.Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge.

The relentless march of scientific progress, propelled by innovative technologies and the promise of artificial intelligence, has ushered in an era of unprecedented knowledge and discovery. Yet, this surge in information and technological advancement has left scholars, researchers, and medical professionals grappling with the immense task of translating this wealth of data into practical solutions for real-world problems. As they strive to enhance our understanding of brain health and tackle conditions and disorders that have eluded resolution for over a century, there is a critical need for a unified and coherent approach. Advances in Neurosciences, Neuropsychiatry, and Neurology is a groundbreaking book that is not just a source of knowledge but a roadmap to resolving the perplexing challenges in these fields. With a laser focus on consolidating theoretical insights and presenting clinically relevant findings, this book stands as a beacon of guidance for those seeking to leverage the transformative potential of technology and scientific advancement. It provides an invaluable toolkit of therapeutic strategies, aimed to seamlessly integrate into clinical practice. For researchers, professionals, and students in the fields of neuroscience, medicine, psychology, and related disciplines, this book is a gateway to a deeper understanding of the remarkable advances that are shaping the future of brain health. Explore a variety of topics, from compelling case reports to thought-provoking theoretical discussions, and let your intellectual exploration be guided by empirical studies and systematic reviews. Advances in Neurosciences, Neuropsychiatry, and Neurology is an invitation to be a part of the solution to the most pressing problems in these fields.

This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved.In thethird edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology.

In diesem Buch wird die Kunsttherapie, ein spezifisches Instrument zur Erhaltung der Gesundheit im Bereich der affektiven Entwicklung, der Rehabilitation, der Motorik und der kognitiven Funktionen, eingehend analysiert und diskutiert. Kunsttherapie basiert auf der Annahme, dass der Prozess des künstlerischen Schaffens – Musik, Tanz, Malerei – Emotionen auslöst und die Gehirnaktivität steigert. Sie wird eingesetzt, um das persönliche Wachstum zu fördern, bestimmte Gehirnbereiche oder Aktivitätsmuster zu unterstützen und die neuronale Vernetzung zu verbessern. Die Behandlung neurologischer Erkrankungen mit künstlerischen Strategien bietet uns eine einzigartige Möglichkeit, die strukturellen Netzwerke des Gehirns zu beeinflussen und die Fähigkeit des Gehirns zur Bildung neuer Verbindungen zu verbessern. Auf der Grundlage der Plastizität des Gehirns hat Kunsttherapie das Potenzial, unser Repertoire zur Behandlung neurologischer Erkrankungen zu erweitern. Neuronale Substrate sind die Grundlage komplexer Emotionen bei Kunsterfahrungen und gehen mit einer umfassenden Aktivierung kognitiver und motorischer Systeme einher. Dementsprechend vermag Kunsttherapie Verhalten, Kognition, Aufmerksamkeit und Bewegung zu modulieren. In diesem Zusammenhang kann die Kunsttherapie wirksame Instrumente zur Verbesserung des allgemeinen Wohlbefindens, der Lebensqualität und der Motivation im Zusammenhang mit neurologischen Erkrankungen bieten. Das Buch erörtert die Kunsttherapie als ein mögliches Verfahren zur Behandlung neurologischer Störungen und nähert sich dem Verhältnis zwischen humanistischen Disziplinen und der Neurologie aus einer ganzheitlichen Perspektive, die das wachsende Interesse an dieser Verzahnung widerspiegelt.Dieses Buch stellt eine Übersetzung einer ursprünglich englischsprachigen Ausgabe dar. Die Übersetzung wurde mithilfe von künstlicher Intelligenz vorgenommen (maschinelle Übersetzung durch DeepL.com). Eine anschließende menschliche Überarbeitung wurde vorwiegend im Hinblick auf den Inhalt durchgeführt, sodass sich das Buch sich stilistisch von einer herkömmlichen Übersetzung unterscheidet.

Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.

Dieses Praxisbuch liefert alles Wesentliche für die Betreuung von Patienten mit Demenz in der Ergotherapie. Wie erfolgt die Befunderhebung bei demenzkranken Menschen? Weshalb sind Angehörige und Zugehörige von demenzkranken Patienten für den Aufenthalt im Krankenhaus von großer Bedeutung? Inwiefern muss bei der Auswahl von Liedern, Gedichten und Spielen die Vergangenheit der einzelnen Patienten berücksichtigt werden? Die Expertin liefert Ihnen die Antworten! Aus dem Inhalt: · Grundlagen zu Gedächtnis und Formen der Demenz · Befunderhebung, Therapie und Methoden · Einzel- und Gruppentherapie, Therapiemittel und –materialien · Selbstsorge für Therapeuten und angrenzende Berufsgruppen Neu in der 6. Auflage:Zusatzkapitel zu Demenzerkrankten im Akutkrankenhaus Erweitern Sie Ihr Wissen und profitieren Sie von der Erfahrung und den Tipps der Expertin!

Dr. Richard Polin's Neonatology Questions and Controversies series highlights the toughest challenges facing physicians and care providers in clinical practice, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient.The thoroughly updated, full-color, 4th Edition of Neurology: Provides a clear management strategy for common and rare neonatal neurological disorders, offering guidance based on the most up-to-date understanding of underlying pathophysiology. Places emphasis on controversial areas that can entail different approaches. Features the most current clinical information throughout, including recent trials for hypoxic-ischemic encephalopathy, acute management of symptomatic seizures, and congenital viral meningoencephalitis: neonatal herpes simplex virus, congenital cytomegalovirus, congenital Zika, and COVID-19. Includes three new chapters on neurological and neurobehavioral evaluation in the neonatal period; white matter injury; and cerebellar hemorrhage in the premature infant. Highlights gaps in knowledge that should serve as a strong stimulus for future research. Utilizes a consistent chapter organization to help you find information quickly and easily, and contains numerous charts, graphs, radiographic images, and photographs throughout. Offers the most authoritative advice available from world-class neonatologists/neurologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume Neonatology Questions and Controversies set, which includes online access that allows you to search across all titles! Gastroenterology and Nutrition Hematology and Transfusion Medicine Neonatal Hemodynamics Infectious Disease, Immunology, and Pharmacology Renal, Fluid, and Electrolyte Disorders Neurology The Newborn Lung

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read on the Oxford Academic platform and offered as a free PDF download from OUP and selected open access locations. Brain Computations and Connectivity is about how the brain works. In order to understand this, it is essential to know what is computed by different brain systems; and how the computations are performed. The aim of this book is to elucidate what is computed in different brain systems; and to describe current biologically plausible computational approaches and models of how each of these brain systems computes. Understanding the brain in this way has enormous potential for understanding ourselves better in health and in disease. Potential applications of this understanding are to the treatment of the brain in disease; and to artificial intelligence which will benefit from knowledge of how the brain performs many of its extraordinarily impressive functions. This book is pioneering in taking this approach to brain function: to consider what is computed by many of our brain systems; and how it is computed, and updates by much new evidence including the connectivity of the human brain the earlier book: Rolls (2021) Brain Computations: What and How, Oxford University Press. Brain Computations and Connectivity will be of interest to all scientists interested in brain function and how the brain works, whether they are from neuroscience, or from medical sciences including neurology and psychiatry, or from the area of computational science including machine learning and artificial intelligence, or from areas such as theoretical physics.

This new edition fully updates and expands Faro and Mohamed's Functional Neuroradiology, a gold standard, comprehensive introduction to the state-of-the-art functional imaging in neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 12 major sections, including: Diffusion and Perfusion Imaging, Magnetic Resonance Spectroscopy and Chemical Exchange Saturation Transfer Imaging, Multi-Modality Functional Neuroradiology, BOLD Functional MRI, Diffusion Tensor Imaging, Presurgical Brain Tumor Mapping, Emerging neuroimaging techniques, Functional Spine and Hydrocephalus imaging, and Neuroanatomical Gray and Whitematter Brain Atlases. This second edition is fully updated throughout and includes more than 15 new chapters on topics such as: Brain tumor Radiogenomics, CNS Tumor Surveillance and Functional MR Perfusion Imaging, CNS Machine Learning, Focused Ultrasound therapy, TBI Sports Related Injury, and CNS Lymphatic system. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.

This new, and heavily revised, edition of Psychopharmacology, provides a comprehensive scientific study of the effects of drugs on the mind and behavior. With the growing prevalence of psychiatric and behavioral disorders and the rapid advances in the development of new drug therapies, this textbook offers an essential understanding of the necessary details of drug action. The book presents its coverage in the context of the behavioral disorders they are designed to treat, rather than by traditional drug classifications, to strengthen understanding of the underlying physiology and neurochemistry, as well as the approaches to treatment. Each disorder from the major diagnostic categories is discussed from a historical context along with diagnostic criteria and descriptions of typical cases. In addition, what we presently know about the underlying pathology of each disorder is carefully described. Providing a solid foundation in psychology, neuroanatomy and physiology, the book also offers a critical examination of drug claims, as well as coverage of evidence-based alternatives to traditional drug therapies. Throughout, this text discusses how drug effectiveness is measured in both human and animal studies. Topics new to this edition include: a stronger emphasis on the environmental impacts on drug effectiveness; more on the mechanisms of adverse reactions to drugs and information on managing drug side effects; the risks and benefits of using'mood stabilizing drugs'to address behavior in youth with ADHD or ASD; and discussion of the research-to-practice gap in pharmacological care for children and adolescents. Accompanied by a robust selection of support material, this textbook is ideal for undergraduate and pre-professional students on courses in Psychopharmacology, Clinical Psychopharmacology, Drugs and Behavior. It is a valuable contribution to highlight the symbiotic relationship between psychopharmacology and the neural and behavioral sciences.

This new edition of Neurosurgery: The Essential Guide to the Oral and Clinical Neurosurgical Exam provides a concise and practical guidebook of the core knowledge and principles for the International and Intercollegiate FRCS Specialty Examination in Neurosurgery. It is a vital resource for the American Board of Neurological Surgery (ABNS) and other neurosurgical examinations around the world. Written by neurosurgeons at the top of their field and based on new guidelines, this book takes students through how to succeed in the FRCS neurosurgery exams and provides an overview of crucial short and intermediate cases designed to mirror the exam's testing of a candidate's clinical knowledge, diagnostic acumen, investigation and interpretation, treatment options and taking consent. Including 72 vital online revision flash cards, covering critical and diverse examination cases from trauma to paediatric spine exams, this edition also contains crucial guidance to Vivas on the following: Operative surgery and surgical anatomy Investigation of the neurosurgical patient The non-operative clinical practice of neurosurgery This book is a must-read for candidates preparing for the final Intercollegiate Specialty Examination in Neurosurgery (UK), International FRCS Specialty Examination in Neurosurgery (UK) International FRCS Specialty Examination in Neurosurgery as well as the American, Canadian, European and Australasian exams. In addition to helping candidates pass their final exams, the book provides wonderful insight into Neurosurgery for Medical Students, Surgical Residents and Neurosurgical Consultants.

This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Fragile X and Related Autism Spectrum Disorders, Volume 172 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on The dopamine hypothesis of Autism Spectrum Disorder: a comprehensive analysis of the evidence, A Review of the Use of Psychotropic Medication to Address Challenging Behavior in Neurodevelopmental Disorders, Lipid metabolism alterations in fragile X syndrome and other neurodevelopmental disorders, Genesis, modelling and methodological remedies to autism heterogeneity, Toward an Understanding of the Role of the Exposome on Fragile X Phenotypes, Glial-mediated dysregulation of neurodevelopment in Fragile X Syndrome, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in International Review of Neurobiology series Updated release includes the latest information on Fragile X and Related Autism Spectrum Disorders

This atlas is the first fully visual reference to cover psychiatry broadly, appealing to psychiatric as well as non-psychiatric clinicians and trainees who need an easy-to-use visual resource with holistic approach to patient care. Written by expert clinicians and educators, this text describes basic clinical and scholarly information across the field utilizing an easy-to-understand format. The rich figures and tables describe etiology, pathophysiology, phenomenology, and treatment even in areas that are difficult to illustrate, including substance-related disorders, neurodegenerative diseases, personality disorders, and others. The visual approach proves valuable to some of the most innovative techniques in psychiatry, including implications for neuroimaging. Comprehensive and unique, Atlas of Psychiatry is a landmark reference for all medical practitioners looking for an intricate yet accessible visual resource.

Clusterkopfschmerz und andere trigeminoautonome Kopfschmerzerkrankungen sind durch wiederkehrende Attacken von einseitigen, intensiven Kopfschmerzen gekennzeichnet. Die Lebensqualität der Betroffenen ist meist stark beeinträchtigt und oft ist es schwierig, kompetente Behandler zu finden. Wie können Betroffene mit den Kopfschmerzattacken umgehen, diesen vorbeugen und auch mit der Erkrankung am sozialen Leben teilnehmen? Dieser Ratgeber stellt wirksame medikamentöse und verhaltenstherapeutische Behandlungsoptionen vor und bietet praktische Übungen für den Alltag. Betroffene erhalten umfassende Information und Hilfestellungen zur Krankheit und deren Bewältigung.

This book introduces neurourology as an emerging interdisciplinary area that covers the basic and clinical studies of the neural control on the normal lower urinary tract and the lower/upper urinary tract dysfunction due to neuropathy disorders. It systematically describes all aspects of neurourology from the epidemiology of the neurogenic bladder; to the pathology and pathophysiology of the lower urinary tract; to the diagnosis and treatment of the neurogenic bladder by conservative therapies or surgeries. This book provides a useful resource for medical doctors, nurses and students in the field of neurourological conditions.In this 2nd edition, 15 chapters are added, e.g. on urodynamic practice, psychogenic reasons of LUTDs, standard of care, physiotherapy, upper urinary tract rehabilitation to enable self-catheterization, pediatric neurourology, new surgical procedures. The editors have invited an impressive number of renowned contributors, including 98 internationally recognized specialists in this field from 25 countries in Europe, Asia, North America, and South America. This handbook provides a useful resource for medical doctors, nurses and students in the field of neurourological conditions.

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their detection by biomarkers.Biomarkers and methods used in critical care and critically ill patients are discussed, as well as biomarkers in trauma and special conditions. Specific biomarker components are explained and models for modeling trauma in research are presented.This systematic handbook is an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and physicians who want a thorough overview of various injuries, trauma, and their detection methods.

Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book. The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, the demonstration of unique clinical and neuroradiological aspects of febrile status epilepticus, and the prospect of predictive (bio)markers to identify and characterize cognitive and epilepsy outcomes are exciting and important. In this edition, the authors and editors tackle these developments in chapters addressing the questions of parents, physicians, allied health care professionals and basic and translational scientists. Reviews all aspects of febrile seizures, including epidemiology, neurobiology and treatment Discusses novel and newly discovered information based on up-to the minute methods Provides an engaging style that is accessible to clinicians, researchers and educated parents

Huntington's disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents adistinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.

This user-friendly, comprehensive and highly relevant book allows readers to gain a better understanding of mental health issues in sport and exercise. The field of sports psychiatry continues to grow globally at a rapid pace. This, in part, can be explained by the changing culture of sport leading to an appreciation of the role of psychiatric symptoms and syndromes in the world of sport, but also the increasing spread of both highly performance oriented and grass-roots basic sports and the associated risks in large sections of the population. The long-standing stigma attached to mental health problems, such as depression, anxiety, ADHD, suicide, brain injuries, substance-abuse, is being challenged not only by high-profile athletes, but also in public health and general mental health services. The book utilizes an innovative case-based and structured didactical format to provide short summaries of recent research by leading experts in the respective fields, as well as up-to date prevention and clinical guidelines for all relevant disorders in a way that is easily accessible to the large and growing groups interested and active in sports. This work is relevant for all mental health professionals and can also be used by a wider readership including medical doctors, psychologists, athletes and coaches. A second volume covers the role of exercise as an effective treatment for a number of common psychiatric conditions, such as depression, anxiety, eating disorders and substance abuse.

This book provides a detailed practically focused guide on the latest diagnostic and treatment techniques available for normal pressure hydrocephalus (NPH). Chapters in this work cover the latest developments related to this condition. It introduces how to use a range of diagnostic modalities including magnetic resonance scanning along with how artificial intelligence and machine learning methodologies can be applied. Cases are presented to reinforce how the methods covered can be appropriately applied and guiding principles are also given to assist the reader in developing a thorough understanding of the topic. Potential complications and means of mitigating these are also described. Normal Pressure Hydrocephalus is a detailed practically applicable resource on NPH with insightful contributions covering relevant aspects of pathophysiology, diagnostic modalities and treatment strategies, making it an ideal resource for all medical practitioners whoencounter these patients.

Recent Advances in the Neurological and Neurodevelopmental Impact of HIV brings together world-leading experts in the field of HIV, to provide new and critical insights into HIV treatment and management for children and adolescents. Those infected with HIV are living longer thanks to antiretroviral drugs, and HIV-related neurological and neurodevelopmental disorders therefore require urgent attention, particularly complications which arise from long-term medication use. The authors summarise key findings in these important areas, as well as gaps in research and implications for paediatric HIV work. Readers will discover ways of optimising the neurological health of children and adolescents living with HIV through better care provision and earlier intervention. ⦁ Outlines the important clinical neurological issues facing children and young adults with HIV infection ⦁ Presents up-to-date diagnostic and treatment approaches ⦁ Provides practical clinical strategies to improve the care of children and adolescents with HIV An essential resource for all clinicians involved in the care of children and adolescents with HIV and their families, including doctors, paediatricians, psychologists, and other health practitioners and researchers.

The 3rd edition of this book provides a comprehensive, fully updated, overview of diabetic neuropathy. Divided into three sections, chapters are authored by leading scientists and physicians in the world. The 1st section, Clinical Features and Diagnosis, discusses the clinical examination of diabetic neuropathy as well as the use of objective point-of-care devices in diagnosis. The 2nd section, Pathophysiology, reviews the pathophysiology of diabetic neuropathy and potential therapeutic targets. The last section, Clinical Consequences and Treatments, reviews the management of diabetic neuropathies as well as the latest treatment options for various neuropathies. Diabetic Neuropathy, Third Edition, will be of interest to clinicians, practitioners, and researchers, as well as students, residents, and fellows.

This book presents a multispecialty and multidisciplinary approach on Amyloidosis and Fabry disease. These two “rare” diseases are underdiagnosed and have systemic peculiarities that should be emphasized for diagnosis. In both cases, early diagnosis is important for initiating treatment sooner, achieving better prognosis, and improving patients'quality of life. The history of these patients, in general, involves a long journey among health professionals to obtain a diagnosis. Even after a patient is diagnosed, there are still difficulties in understanding these complex diseases, managing complications, and defining specific treatment. Therefore, this work will be a valuable resource for many healthcare professionals, including physicians of various specialties, nurses, physiotherapists, and medical students. It will also be of interest to patients who would like to understand Amyloidosis and Fabry disease. The content will give healthcare professionals a clinical perspective and provide insights on proper care. Readers will be able to recognize the symptoms related to each disease and will be guided during diagnosis and treatment. Chapters include an overview on clinical course, and will address neurological, ophthalmological, dermatological, gastrointestinal, hematological and cardiology manifestations, orthopedic care, mutations, expressiveness according to epigenetics and multidisciplinary treatment. Chapter authors from around the world will contribute sharing their experience in managing these diseases.

In'Fast Facts: Early Hearing'Detection and Intervention an international team of contributors brings together the evidence that supports the effectiveness of universal newborn hearing screening (UNHS) and early hearing detection and intervention services (EHDI). As well as considering elements essential to successful UNHS/EHDI programs, including screening technologies, resources, data management and family-centered early intervention services, the team discusses the resources needed to deliver such programs as well as the performance of screening programs globally. The aim is to provide a comprehensive compendium of information to make the case for greater recognition of the importance of UNHS/EHDI and so improve the life chances of children who are diagnosed as deaf or hard of hearing. Table of Contents: • Newborn hearing screening and EHDI • Rationale for UNHS/EHDI programs • Prevalence of newborn hearing loss and performance of screening programs • Global status of newborn and infant hearing screening • Genetic and CMV testing • Medical evaluation and management of permanent childhood hearing loss • Middle ear effusion and other barriers to timely diagnosis • Data management systems for newborn hearing screening programs • Establishing UNHS/EHDI programs • Pediatric diagnostic audiology • Amplification device fitting • Family-centered early intervention • Unilateral hearing loss and auditory neuropathy spectrum disorder

Learn more about how the central nervous system governs human behaviour with an industry-leading text. Biopsychology, Global Edition, 11th Edition by authors John Pinel and Steven Barnes presents a clear, engaging introduction to the topic offering a unique combination of biopsychological science and personal, reader-oriented discourse, ideal for students studying Physiological Psychology and Biopsychology courses. Well-known for its accessible and student-focused approach to the discipline, the book successfully interweaves the fundamentals of the field with clinical case studies, social issues, personal implications, useful metaphors, and memorable anecdotes. The plethora of themed features, and visual illustrations will challenge your critical thinking skills and support your understanding of the concepts introduced. The latest Edition also incorporates two new emerging themes (Thinking About Epigenetics'and'Consciousness') and includes up-to-date coverage of the most recent developments in the field.

The second edition of The Neurologic Examination looks at how to conduct a clinical neurological examination through a pathophysiological approach to the nervous system. This new edition is brought up to date with new data on genetic and immunological disorders and a significant expansion of illustrations of skin manifestations of neurologic disorders. The book provides in-depth instructions for clinicians with a logical order of history and the different parts of the examination. Organized by the functional anatomy of the nervous system, the book provides a bridge from basic science to symptoms and signs of many common and rare neurologic disorders, which will help in making diagnoses. The authors look at how to carry out an examination in different circumstances, from outpatients to patients in respiratory distress, with stroke and epilepsy, and various states of consciousness including coma. Laboratory testing is recommended when appropriate, but the main emphasis is on history and physical examination. The book contains over a hundred discussion boxes with details about neurologic disorders and history. While mainly directed to students and residents learning how to do a neurologic examination, it will still be useful even for more experienced clinicians.

Introduction to Basic Aspects of the Autonomic Nervous System, Sixth Edition, Volume One is an all-encompassing reference on the autonomic nervous system's basic function, dysfunction and pathology. This volume describes the anatomy of the autonomic nervous system and its role in the regulation of blood pressure, body temperature, respiration, micturition, digestion and renal function. Additional chapters focus on the autonomic modulation of the neuroendocrine system, sexual function, and immunity. There is also a chapter on mummies and the autonomic nervous system. With these chapters, readers will gain extensive knowledge on the autonomic nervous system's anatomy, functional organization and neurochemistry, which is critical to care for patients with autonomic disorders and guide patient-oriented research. Provides an extensive reference on the autonomic nervous system and its crucial functions and dysfunction Discusses all aspects of autonomic physiology and pathology Outlines several physiological processes regulated by the autonomic nervous system, including thermoregulation, blood pressure, micturition, respiration, digestion and renal function Features chapters on the modulation of the neuroendocrine system, sexual function, immunity, and a new chapter on mummies and the autonomic nervous system

The Temporal Lobe, Volume 187 covers the exponential growth of studies on the relationships between brain and language/cognition, many of which involved the temporal lobe. This volume summarizes research on the anatomy and function of the temporal lobe under both normal and pathological conditions. In addition, it discusses the interactions of the temporal lobe with other brain structures. The book highlights the role of the temporal lobe in language processing as well as vision, object, face recognition and processing. The book also discusses the temporal lobe's role in reading, speech and the processing of color, music, action and memory. Temporal lobe disorders, assessments and treatments are also covered, including encephalitis, Alzheimer's, epilepsy, Korsakov's syndrome, and more. Summarizes research on the anatomy and function of the temporal lobe Identifies the importance of the temporal lobe to language and speech Includes how the temporal lobe interacts with other brain structures Reviews disorders of the temporal lobe, including dementia, encephalitis, and more

“This updated textbook was much needed as there has been increased attention in recent years toward brain injuries. The book provides updated guidelines and clinical practice recommendations that support the intended audience of trainees and current practitioners. This update makes it the current standard text for any brain injury specialist.'---Doody's Review Service, 4 stars This revised and greatly expanded Third Edition of Brain Injury Medicine continues its reputation as the key core textbook in the field, bringing together evidence-based medicine and years of collective author clinical experience in a clear and comprehensive guide for brain injury professionals. Universally praised as the gold standard text and go-to clinical reference, the book covers the entire continuum of care from early diagnosis and assessment through acute management, rehabilitation, associated medical and quality of life issues, and functional outcomes. With 12 new chapters and expanded coverage in key areas of pathobiology and neuro-recovery, special populations, sport concussion, disorders of consciousness, neuropharmacology, and more, this'state of the science'resource promotes a multi-disciplinary approach to a complex condition with consideration of emerging topics and the latest clinical advances. Written by over 200 experts from all involved disciplines, the text runs the full gamut of practice of brain injury medicine including principles of public health and research, biomechanics and neural recovery, neuroimaging and neurodiagnostic testing, sport and military, prognosis and outcome, acute care, treatment of special populations, neurologic and other medical complications post-injury, motor and musculoskeletal problems, post-trauma pain disorders, cognitive and behavioral problems, functional mobility, neuropharmacology and alternative treatments, community reentry, and medicolegal and ethical issues. Unique in its scope of topics relevant to professionals working with patients with brain injury, this third edition offers the most complete and contemporary review of clinical practice standards in the field. Key Features: Thoroughly revised and updated Third Edition of the seminal reference on brain injury medicine Evidence-based consideration of emerging topics with new chapters covering pathobiology, biomarkers, neurorehabilitation nursing, neurodegenerative dementias, anoxic/hypoxic ischemic brain injury, infectious causes of acquired brain injury, neuropsychiatric assessment, PTSD, and capacity assessment Multi-disciplinary authorship with leading experts from a wide range of specialties including but not limited to physiatry, neurology, psychiatry, neurosurgery, neuropsychology, physical therapy, occupational therapy speech language pathology, and nursing New online chapters on survivorship, family perspectives, and resources for persons with brain injury and their caregivers Purchase includes digital access for use on most mobile devices or computers

This book provides healthcare professionals in Critical Care setting an easy consultation guide to fight against COVID-19. The book is divided into sections: Fundamentals of COVID-19, Pneumological critical care, Neurological manifestations, Cardiovascular manifestations, Renal manifestations, Haemostasis and coagulation, Other multi-organs involvement, Principles of therapy. Each section includes: · brief pathophysiology of COVID-19 (ventilation, neurological, cardiovascular, etc.); · principles of management (enriched with flowcharts and figures); · principles of therapy; · tips and key messages. Readers can find the most updated advices on how to face the ongoing pandemic: from principles of conventional oxygen therapy, assisted and invasive mechanical ventilation in critically ill COVID-19 patients to the complications sometimes underestimated. Tables and flowcharts provided are based on current knowledge in COVID-19 to help the clinician managing COVID-19 patients by a multiple-organs prospective. Written by international key opinion leaders of each field, the book represents a point of reference for all professionals involved in the management of COVID-19 pandemic.

This volume elucidates the pivotal ethical and legal issues arising from the use of brain organoids for research, therapeutic and enhancement purposes.The function of the human brain is still a mystery. Until recently, only post-mortem tissue was available for a structural examination of the brain. Consequently, the examination results could only reflect the state at the end of life. However, in order to better understand the development and function of the human brain, dynamic and functional investigations of different human brain cells are necessary. This is where brain organoids, artificially grown in vitro miniature brains, provide the opportunity for more flexible research scenarios.At the same time, however, the use of brain organoids in research and therapy raises the question of how these new entities are to be treated from an ethical and legal point of view. Against this background, this volume aims at clarifying the normative implications of the use of brain organoids in research and therapy. The ethical reflections on the status of brain organoids, informed consent, human-to-animal chimeras and neuro-enhancement are mirrored by corresponding legal analyses. The ethical and legal assessments are preceded by an introduction to the scientific and medical background of the brain organoid technology. A final chapter will be devoted to the issue of whether international harmonization of normative standards for brain organoid research and therapy is feasible and advisable.