1. Virtual ADMET Assessment in Target Selection and Maturation
- Author
-
B. Testa, L. Turski and B. Testa, L. Turski
- Subjects
- Pharmacokinetics, Drugs--Design, Drugs, Drug development--Data processing--Congresses, Drug development--Congresses
- Abstract
Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods.
- Published
- 2006