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This book presents an integrative, dualist model of mental disorder for psychiatry, as a counter to the so-called'biomedical'approach that dominates the field today. Starting with the humanist concept that mental disorder is real, it uses a computational approach to build a genuinely bio-psycho-social model. This shows that mental disorder is primarily psychological in nature, not biological. The historical background extends as far as Descartes, and proceeds via some of the revolutionary thinkers who have shaped modern society. In particular, it builds on the work of George Boole, Alan Turing and Claude Shannon to construct a radically new concept of the mind as a real, informational space which, for better off for worse, can malfunction. It extends this idea to build models of personality, of personality disorder, and then of mental disorder. Finally, the concepts are tested against a variety of themes from other fields to show its generality. Based in the philosophy of science and of mind, this work represents a radical departure from anything in the history of psychiatry. Its purpose is to provide a formal, articulated model of mental disorder to fill the theoretical void at the core of modern psychiatry. This book is written for medical students and recent graduates, for psychiatrists, psychologists, social workers and, broadly, anybody with an interest in human affairs, such as philosophy, politics and other related fields.

Psychiatry Reborn: Biopsychosocial Psychiatry in Modern Medicine is a comprehensive collection of essays by leading experts in the field, and provides a timely reassessment of the biopsychosocial approach in psychiatry. Spanning the sciences and philosophy of psychiatry, the essays offer complementary perspectives on the ever more urgent importance of the biopsychosocial approach to modern medicine. The collection brings together ideas from the series of Loebel Lectures by world leaders in the field of psychiatry and associated Workshops at the University of Oxford, including revised versions of the Lectures themselves, and a wide range of related commentaries and position pieces. With contributions from psychiatry, psychology, neuroscience, and philosophy, the book provides the most comprehensive account to date of the interplay between biological, psychological, and social factors in mental health and their ethical dimensions. The 23 chapters of this multi-authored book review the history and place of the biopsychosocial model in medicine, and explore its strengths and shortcomings. In particular, it considers how understanding this interplay might lead to more effective treatments for mental health disorders, as developments in genomic and neurobiological medicine challenge traditional conceptions and approaches to the research and treatment of mental health disorders. The book explores the challenges and rewards of developing diagnostic tools and clinical interventions that take account of the inextricably intertwined bio-psycho-social domains, and the ethical implications of the conceptualization. It concludes with chapters drawing together the book's range of expertise to propose a best conception of the model, and how it might be adopted going forward in an age of exponentially increasing technological advances and of integrated/collaborative care. The volume is intended to present the BPS model as it stands today in the academy, the lab, and the clinic, and to start to address the challenges and potential that the model has for each.

This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers'for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.

La práctica psiquiátrica ha sido objeto de controversia desde distintos puntos de vista. La medicina la ha considerado una especialidad rezagada e inaccesible; la psicología la ha acusado de negligencia en el estudio de la vida psíquica normal; la sociología ha señalado su desarrollo descontextualizado y sus efectos discriminadores, y la biología ha contado muy poco con ella para el estudio del funcionamiento del cerebro. Por añadidura, la ideología y la política también la han zarandeado a conveniencia, en ocasiones usando partituras de cierta pobreza intelectual. Son pocas las instancias culturales que no se han pronunciado en algún momento sobre la naturaleza de las alteraciones psiquiátricas, inevitablemente presentes en la historia de la epopeya humana. Los psiquiatras no pueden permanecer callados, por muy exhaustos que estén de tanto discutir con unos y con otros. Es por ello que en este libro, ganador de la primera edición del Premio Staccato de Ensayo en Psiquiatría, se hace un (breve) análisis crítico de la historia de la psiquiatría como especialidad médica, y se propone un desarrollo alternativo, fundamentado en los progresos de la biología, en la incorporación de nuevas áreas de conocimiento biomédico y en una epistemología rigurosa que deje el menor margen posible a la mera opinión.

As long-term cancer survival becomes a widely-shared experience, the quality of life of people living with and beyond a cancer diagnosis is increasingly important. Optimising the prevention and treatment of any psychiatric consequences of certain tumours and treatments is now central to high-quality cancer care. Biological Psychiatry of Cancer and Cancer Treatment provides the reader with expert guidance on how to prevent, detect and manage the'organic'psychiatric disorders experienced by people with cancer. Containing 13 chapters on topics from'Surgery and Radiotherapy', and'Hormone and Cytokine treatments'to'Clinical Psychiatric Assessment of Patients with Cancer'this unique resource offers readers with fully up-to-date and high-quality information on how to enhance the quality of life for patients living with, and beyond cancer. Offering a unique approach to oncology and psycho-oncology, Biological Psychiatry of Cancer and Cancer Treatment is an invaluable resource for academic psychiatrists, liaison psychiatrists, neuropsychiatrists, Oncologists, neuro-oncologists, palliative medicine doctors and drug development scientists.

The discovery of chlorpromazine for the specific treatment of schizophrenic symp­ toms and, later on, of imipramine for the specific treatment of depressive symptoms marked a new milestone in clinical psychiatry and basic neuroscience 40 years ago. The exploration of biochemical mechanisms of action of these psychotropic drugs created new theories on the pathophysiology of psychiatric disorders, such as the dopamine hypothesis of schizophrenia and the catecholamine and serotonin hypotheses of depression. Thus the discovery of these biological treatments had a major impact on natural science-oriented research. Biological psychiatry as we know it today has its origin in these psychopharmacological drugs and influences many disciplines in psychiatry. It was a fortunate coincidence that Hans Hippius, whose 70th birthday we celebrated this year with an international symposium, started his professional career during this time in the 1950S. He was one of the early pioneers in clinical psycho­ pharmacological research and enthusiastic about both the scientific and the thera­ peutic prospects of the new psychotropic drugs. He has worked in this field for more than three decades and has made many lasting contributions to biological psychiatry. Among the many activities, his contributions in the development of the new atypical antipsychotic drug clozapine should be mentioned.

Written by an experienced nurse lecturer who also trained as a mental health nurse, this book explores the underlying biology associated with the pathology of mental health disorders and the related nervous system. Fully revised for this second edition, the text includes three new chapters on brain development,pharmacology and learning, behavioural and developmental disorders. Integrating up-to-date pharmacological and genetic knowledge with an understanding of environmental factors that impact on human biology, The Biological Basis of Mental Health Nursing covers topics including: the physiology of neurotransmission and receptors hormones and mental health the biology of emotions, stress, anxiety and phobic states the biology of substance abuse the pharmacology of psychoactive drugs developmental disorders brain anatomy and development the biology of behaviour genetics and mental health affective disorders: depression, mania and suicide schizophrenia autism and other syndromes the ageing brain and dementia degenerative diseases of the brain epilepsy. Accessibly laid out, with many of diagrams, tables and key points at the end of each chapter, this is an essential text for mental health nursing students, practitioners and educators.

The long-awaited final installment of the Biocognitive Model Series Humanizing Psychiatrists is the third of a series directed at developing the Biocognitive Model of Psychiatry as the replacement for the three nineteenth century models of mental disorder, psychoanalysis, behaviorism and biological psychiatry. In this volume, the author continues to explore the logical status of theories used in psychiatry. He shows that Dennett's functionalism and Searle's biological naturalism cannot be used as the basis for a theory for biological psychiatry. He argues that phenomenology is a valuable technique but can never form a genuine theory. in addition, he shows how orthodox psychiatry uses its publishing industry to suppress criticism of itself, which is a gross breach of scientific ethics. He then shows how his Biocognitive Model of Mind can be applied to clinical practice with dramatic results. Praise for Niall McLaren's Biocognitive Model of Mind'This book is a tour de force. It demonstrates a tremendous amount of erudition, intelligence and application in the writer. It advances an interesting and plausible mechanism for many forms of human distress. It is an important work that deserves to take its place among the classics in books about psychiatry.'--Robert Rich, PhD, AnxietyAndDepression-Help.com'Dr. McLaren brilliantly wields the sword of philosophy to refute the modern theories of psychiatry with an analysis that is sharp and deadly. His own proposed novel theory could be the dawn of a new revolution in the medicine of mental illness.'--Andrew R. Kaufman, MD Chief Resident of Emergency Psychiatry Duke University Medical Center About the Author Niall McLaren, M.D. is a psychiatrist practicing in Darwin, in the far north of Australia. He has long had an interest in the philosophical and logical status of theories used in psychiatry.His work is radical in the extreme but he sees no option if psychiatry is to move beyond its present status as an ideology and finally into the realm of the sciences. For more information please visit www.NiallMcLaren.com

Biological psychiatry has dominated psychiatric thinking for the past 40 years, but the knowledge base of the discipline has increased substantially more recently, particularly with advances in genetics and neuroimaging. The third edition of Biological Psychiatry has been thoroughly updated taking into account these developments. As in the earlier editions of the book, there are comprehensive reviews and explanations of the latest advances in neurochemistry, neuroanatomy, genetics and brain imaging— descriptions not only of methodologies but also of the application of these in clinical settings. It is within this context that there is a considerable emphasis in the book on brain–behaviour relationships both within and without the clinical setting. This edition has been enhanced by the inclusion of new chapters, one on anxiety and another on motivation and the addictions. The chapter that relates to treatments has been extended to include the latest information on brain stimulation techniques. The overall book is well illustrated in order to help with an understanding of the text. For the third edition, Professor Michael Trimble has been joined by Professor Mark George as co-author. These are two of the world's leading biological psychiatrists who both have considerable clinical as well as research experience which they have brought to the book. Unlike multiauthored texts, it has a continuity running through it which aids understanding and prevents repetition. This book is strongly recommended for all practising psychiatrists and trainees wishing for an up-to-date, authoritative, easy to digest and acessible review of the latest advances and conceptualizations in the field. It will also appeal to neurologists interested in neuropsychiatry and biological psychiatry or the psychiatric aspects of neurological disorders, as well as other practising clinicians (psychologists, social workers, nurses) in the mental health field.

Does psychiatry have a future? Assailed from many directions, under constant attack for its reliance on'a drug for all problems'and increasingly unable to attract bright new trainees, the specialty is showing every sign of terminal decline. The reason is simple: modern psychiatry has no formal model of mental disorder to guide its daily practice, teaching and research. Unfortunately, the orthodox psychiatrists who control this most conservative profession are utterly antagonistic to criticism. Despite the evidence, they maintain a blind faith that'science will deliver the goods'by a biological examination of the brain. This book argues that their faith is entirely misplaced and is contributing to the destruction of an essential part of civilized life, the fair and equitable treatment of people with mental disorders. The author offers a rational model of mental disorder within the framework of a molecular resolution of the mind-body problem. Fully developed, this model will have revolutionary consequences for psychiatry--and the mentally-afflicted. Acclaim for the writing of Niall Mclaren, M.D.'This book is a tour de force. It demonstrates a tremendous amount of erudition, intelligence and application in the writer. It advances an interesting and plausible mechanism for many forms of human distress. It is an important work that deserves to take its place among the classics in books about psychiatry.'--Robert Rich, PhD, AnxietyAndDepression-Help.com'Dr. McLaren brilliantly wields the sword of philosophy to refute the modern theories of psychiatry with an analysis that is sharp and deadly. His own proposed novel theory could be the dawn of a new revolution in the medicine of mental illness.'--Andrew R. Kaufman, MD, Chief Resident of Emergency Psychiatry, Duke University Medical Center'I found Niall McLaren's book to be an incredibly well-written and thoughtprovoking. It is not, by any means, easy reading. It is also not for someone who doesn't have some form of background in understanding the various psychological theories and mental health conditions. I think that this would make an excellent textbook for a graduate class that allows students to question the theories that we already have.'--Paige Lovitt for Reader Views About the Author The author is a psychiatrist of some 35 years standing. He writes philosophy in the bush outside Darwin, northern Australia, with his family as critics. For six years, while working in Western Australia, he was the world's most isolated psychiatrist. For more information please visit www.FuturePsychiatry.com PSY018000 Psychology : Mental Illness MED105000 Medical : Psychiatry - General PHI015000 Philosophy : Mind & Body

Four years have passed since the last edition (3rd) of this book was published. In the intervening years, several reviews of this book have provided highly encouraging remarks about the value of this book in transmitting information on classification and treatment of psychiatric disorders to the audience. We are proposing to revise all chapters with an eye on accuracy and ease of use, and this is an especially timely endeavor with the upcoming publication of the Diagnostic and Statistical Manual V. All the appropriate new information on biology, etiology, diagnosis and treatment of psychiatric disorders will be added to the current proposed edition. It is our goal to recruit the same authors (if possible) who contributed to the previous edition. While all chapters will be updated (see TOC), those marked by asterisks will be the most likely to undergo more revision. Psychiatry has emerged as a burgeoning scientific field with major advances in etiology and treatment of several disorders. Just as there was excitement in the anatomic advances that took place a hundred years ago when Emil Kraepelin and his collaborators took on the enormous task of classification of psychiatric disorders based on rational scientific thinking, new advances in genetics, biochemistry, neuroanatomy and pharmacotherapy of mental disorders have brought us even closer to a better understanding of complex disorders like schizophrenia, bipolar disorder, depression and even autism. The major goal of the previous edition of this classic book was to update the busy clinician, psychiatric resident and medical student with the most up-to-date information on etiology, diagnosis and treatment of psychiatric disorders. This goal remains the focus of the fourth edition of this book. In this updated and expanded edition, the reader will be provided with the most contemporary information and literature supported by a close survey of the field. This new edition of this classic title, with its focus on biologic and medical aspects of psychiatry, will continue to be of significant help to all interested in the scientific practice of psychiatry.

Completely revised and updated, this Second Edition spans every issue related to ADD care and treatment. New chapters focus on emerging issues, the overlap of sleep disorders, how sleep disorders mimic ADD/ADHD and/or increase the symptoms, ADHD and sleep apnea, ADHD and restless legs or periodic limb movements in sleep, sleep in children, adolesce

Andrew Lakoff argues that a new'pharmaceutical'way of thinking about and acting upon mental disorder is coming to reshape not only the field of psychiatry, but also our very notions of self. Drawing from a comprehensive ethnography of psychiatric practice in Argentina (a country which boasts the most psychoanalysts per capita in the world) Lakoff looks at new ways of understanding and intervening in human behaviour. He charts the globalization of pharmacology, particularily the global impact of US psychiatry and US models of illness, and further illustrates the clashes, conflicts, alliances and reformulations that take place when psychoanalytic and psychopharmacological models of illness and cure meet. Highlighting the social and political implications that these new forms of expertise about human behaviour and human thought bring, Lakoff presents an arresting case-study that will appeal to scholars and students alike.

Quem lê os artigos em jornais e revistas que oferecem dicas e soluções para o bem-viver tem a impressão de que os diversos campos da medicina estão à disposição para tornarem as pessoas mais felizes às custas de alguns medicamentos e uma ou outra intervenção cirúrgica. Nas últimas décadas, a partir do lançamento do Prozac, palavras como?depressão?,?serotonina? e outras se tornaram parte de nosso cotidiano? um cenário relacionado com um modelo que busca a felicidade através das sensações corporais e não mais da realização intelectual. Como conseqüência, vivemos um momento de excessiva medicalização da sociedade, onde a psiquiatria biológica se tornou o discurso hegemônico sobre os transtornos mentais, apesar da frágil sustentação teórica desta corrente. A psiquiatria, antes situada na fronteira dos domínios médico, social e moral, encontra-se agora reduzida ao corpo. Em A Psiquiatria no divã, Adriano de Aguiar descreve os modos de funcionamento dos discursos e práticas da psiquiatria contemporânea, marcada pela hegemonia da psiquiatria biológica, procurando entender não o que ela é, mas como ela funciona, quais os dispositivos a que ela se conecta e que novas realidades e subjetividades ela traz. Um estudo instigante que transcende a discussão sobre a clínica psiquiátrica e contribui para a reflexão sobre a sociedade contemporânea.

The multidisciplinary field of developmental psychobiology has uncovered new findings in behavioral progressions that have led to exciting avenues for therapeutic intervention. Developmental Psychobiology examines typical and atypical behavioral and neural development, reflecting a broad sampling of this multidisciplinary field in its five densely informative chapters. Here, ten contributors discuss early attachment, face processing, reading disability, Tourette's syndrome, and schizophrenia as a disorder of neurodevelopment -- emphasizing three fundamental topics that are especially relevant to biological and child psychiatry: • Learning and development and the methods for studying them -- Understanding normal progressions as a dynamic behavioral and neural process will have a significant impact in determining the biological substrates of clinical disorders and how we can target effective treatments and interventions for behaviors such as the waxing and waning of symptoms in Tourette's syndrome and OCD, eye contact and gaze in autism, word reading in dyslexia, and working memory in schizophrenia.• The establishment of typical and atypical developmental progressions in systems -- Both plasticity and stability are critical in the normal development of behavioral and neural systems. For example, certain behaviors are appropriate at one age but inappropriate at other ages, whereas some clinical disorders may not diminish or change with age and may be viewed instead as developmental delays or deficiencies.• The impact of methodological advances on imaging and genetics in understanding typical and atypical behavioral and neural development -- How have developments in noninvasive tools for looking into the developing, behaving human brain -- imaging, computational modeling and genetic techniques -- helped us to inform or constrain our understanding of typical and atypical development? Until now, biological psychiatry has been based on psychopharmacological work, but now, with imaging and genetic techniques, we can further characterize the biological mechanisms underlying a disorder. With chapters that elucidate the newest research in the field, Developmental Psychobiology provides clinicians an abundance of insight that can provide practical help to patients and a richer understanding of the underpinnings of cognitive and emotional disorders.

This essential text for mental health nursing students, practitioners and educators explores the underlying biology associated with the pathology of mental health disorders and the related nervous system.

In this authoritative volume you'll find today's most important molecular neurobiological advances and their relevance to clinicians treating patients with mental illness. Molecular Neurobiology for the Clinician, Review of Psychiatry, Volume 22, will update you on the latest findings -- and their impact on psychiatry. You'll learn about • Discoveries with the potential to revolutionize your clinical approach by changing the ways in which you diagnose and treat patients• The effects on psychiatry of advances in the molecular basis of neuronal network function, particularly in relation to abnormalities in cognitive and emotional regulation, and the identification of novel molecular targets for drug development• How to apply these discoveries to diagnosing and treating major psychiatric disorders, including childhood- and adolescent-onset disorders, schizophrenia, drug addiction, and severe mood and anxiety disorders Molecular Neurobiology for the Clinician is an outstanding compilation of the best research by top names in the field. Psychiatrists, psychologists, psychiatric residents, and graduate students in neuroscience, psychiatry, and psychology will gain knowledge, understanding, and techniques for better diagnosis and treatment.

This volume examines attempts to identify genetic risk factors and environmental components contributing to the development of psychiatric disorders. It explores the symptoms, courses, outcomes, treatment responses and aetiologies of a range of psychiatric illnesses to improve disease classification schemes.

The 1990s, appropriately termed'the decade of the brain,'witnessed unprecedented advances in our knowledge of psychiatric neuroscience. Yet with every advance, we realized afresh that we were still in the beginning stages of a much longer journey.This text chronicles the next step of that journey. Structured around a proven teaching methodology that uniquely integrates the clinical aspects of psychiatric disorders with their neurobiology, this volume begins with two introductory chapters on functional neural circuitry and neural signaling pathways. The remaining six chapters present current knowledge on the neuroanatomic and neurochemical mechanisms underlying schizophrenia, addiction, anxiety, depression, bipolar disorder, and dementia/Alzheimer's disease. For clarity and consistency, each chapter features the same four divisions -- clinical presentation, neural circuitry, signaling pathways, and psychopharmacology -- as they relate to • Schizophrenia, which reviews studies of the neural basis of schizophrenia and describes how the cortex, the thalamus, the basal ganglia, and the medial temporal lobe work together during normal brain function and then how each is perturbed in psychosis. • Addiction, which focuses on the consequences of psychoactive substance use, including compulsive practices (e.g., eating, sex, Internet browsing) that might also involve the same brain circuits and signaling pathways. Of exceptional value are two unique illustrations that capture -- for the first time -- much of what we know about the anatomy and neurochemistry underlying the behavioral symptoms of addiction.• Anxiety, which presents current hypotheses regarding neurocircuitry and signaling pathways for the three best-studied (from a neurobiologic perspective) anxiety disorders: panic disorder, posttraumatic stress disorder, and obsessive-compulsive disorder.• Depression, which offers evidence for the involvement of highly interconnected cortical and limbic structures such as the prefrontal cortex, medial thalamus, amygdala, ventral striatum, hippocampus, and the hypothalamic-pituitary-adrenal axis in unipolar major depression, and suggests target areas (such as the cAMP pathway) for study in the development of new antidepressants.• Bipolar disorder, which shows that specific abnormalities in signal transduction pathways, including protein kinase activity, G protein levels, and gene expression, are unique to bipolar patients, concluding that the actions of lithium and anticonvulsants on intracellular signaling pathways provide a new paradigm for novel pharmacological interventions. • Dementia and Alzheimer's disease, which details current findings on neurofibrillary degeneration, relevant genes and proteins, pathogenesis (metabolic decline, defective cell repair, and Aß toxicity), and treatment strategies (neurotransmitter replacement, and neuroprotective and regenerative approaches). Discusses frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease, and vascular dementia. Meticulously researched and clearly written by 15 contributors -- all recognized experts from leading research and teaching institutions in the United States -- this compact and extensively illustrated volume stands out in the literature because it combines readability and practicality with the breadth and depth typically found only in far lengthier works. Psychiatric practitioners, residents, and students alike will welcome this informative, easy-to-read text, which will also be of special interest to mental health and pharmaceutical industry professionals, and of general interest to anyone who wants to know more about the biology of psychiatric illness.

How do brain, mind, matter, and energy interact? Can we create a comprehensive model of the mind and brain, their interactions, and their influences? Synthesizing research from neuroscience, physics, biology, systems science, information science, psychology, and the cognitive sciences, The Neurophysics of Human Behavior advances a unified theory of

Essential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtain

This practical volume furnishes a critical overview of the biological basis of bipolar affective disorder-relating theoretical biological models to clinical practice, summarizing current research as well as future directions for investigations, and providing a solid foundation for clinical interventions in bipolar illness.Ensures the clinical applicability and relevance of discussions by describing the importance of findings for the pathophysiology, symptomatology, course of illness, and pharmacotherapy of the disorder!Bipolar Disorderexamines the role of classic neurotransmitter systems implicated in mood disorder explores postreceptor signal transduction mechanisms in the pathophysiology of bipolar disorder and their relevance to mood-stabilizing treatments addresses advances in techniques for gaining more direct access to the diseased brain, such as neuroanatomical models and brain imaging studies develops a conceptual and theoretical framework for understanding how biological mechanisms affect clinical presentation, course of illness, and response to treatments of complex disorder compiles the latest results from various fields to form a basis for specific hypotheses about underlying biological disturbances in bipolar illness delineates ways in which the biology of bipolar disorder differs from other psychiatric diseases, including mood and anxiety disorders and schizophrenia locates specific findings within the context of present pharmacotherapy and other treatments, illustrating how they may direct development of new treatment strategies and more!Supplemented with references, tables, drawings, and photographs, Bipolar Disorder is a necessary resource for psychiatrists, neurologists, pharmaceutical and behavioral scientists, and medical school and graduate students in these disciplines.

The goal of this book is to provide a conceptual framework for understanding the relationship between the';psychological'; areas of medicine and the more somatic aspects of health care in our current social environment.