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This book provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of Chronic obstructive pulmonary disease (COPD), emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in COPD.

Pocket Prescriber Pulmonary Medicine is a concise, up-to-date prescribing guide containing all the ‘must-have'information that clinical professionals treating patients with respiratory conditions need to know. This book provides focused information for all health professionals prescribing drugs for or to patients with a respiratory condition and is an essential guide for pulmonologists, intensive care physicians, emergency medicine doctors and general practitioners and nurse prescribers, in training and in practice.

The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine.

This volume covers data describing the role of free radicals and antioxidants in respiratory disorders, including the data that deal with clinical and pre-clinical trials. Chapters describe the relationship of oxidative stress to a number of respiratory and pulmonary conditions from a basic science and clinical perspective, including chronic obstructive pulmonary disease, asthma, acute lung injury, pulmonary hypertension, toxicity and fibrosis, cancer and asbestosis. The book also discusses the use of conventional biomarkers of oxidative stress and breath condensates as adjuncts to classical laboratory testing, the effect of antioxidants on cellular protection, as well as the development of novel antioxidant modalities.

This issue of Clinics in Chest Medicine is Guest Edited by Peter J. Barnes FRS, FMedSci from Imperial College London and will fosus on COPD. Article topics include epidemiology, pathophysiology, cellular and molecular mechanisms and comorbidities of COPD, diagnosis and phenotype of COPD, pulmonary rehabilitation, asthma and COPD, biomarkers, bronchodilators, non invasive ventialtion, and new drug therapies.

The book includes recommendations for COPD from published guidelines (eg, the GOLD, ATS, and NICE guidelines) and presents them in the context of relevant clinical treatment issues. This is an in-depth guide on the management of COPD, concentrating on the impact of COPD on a patient as well as how healthcare professionals can intervene and educate the patient at an early stage and thereby slow the onset of severe symptoms.

The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology.

Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.

This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has changed dramatically in recent years, and much of this new information is brought together in this volume written by inter­ nationally recognised authorities. The aim of the book is to review in depth the changing concepts of inflammatory processes in asthma and to discuss the implications for research of this common chronic disease. Many of the advances in and future therapy our understanding of asthma have originated from a pharmacological approach, and this volume highlights the promising new options for pharma­ cological intervention. It is hoped this book will be invaluable for research scientists and clinic­ ians involved in asthma research and will be a major reference resource for chest physicians and those involved in the development of novel pharmaceu­ tical entities. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN and A. LAmNEN. With 10 Figures...................... 1 A. Introduction................................... 1............... B. Methods to Investigate the Pathology of Human Asthma............ 1 C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks........................... 2 I. Mast Cells.................................. 4.............. II. Eosinophils............................................... 7 III.Neutrophils.............................................. 10 D. Bronchial Epithelial Inflammation During an Asthma Attack........ 10 E. Epithelial Regeneration.............................. 12.........

Managing COPD is an in-depth guide on the management of patients with COPD concentrating on the impact of COPD on a patient as well as how healthcare professionals can intervene and educate the patient at an early stage and thereby slow the onset of severe symptoms. This book has been designed to increase physician awareness of the pathological processes involved in the aetiology of COPD which underpins effective disease management.

Written as a concise clinical reference guide covering the current and future airway disease treatments, this text encompasses: pathophysiology of respiratory tract diseasesthe methods of measuring airway and clinical responsesthe concepts upon which many treatments are used in COPD and asthma conditionsthe way in which these treatments work,

Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.• Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management• Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD • Most extensive reference to primary literature on both Asthma and COPD in one source.• Easy-to-read summaries of the latest advances alongside clear illustrations

Chronic Obstructive Pulmonary Disease (COPD) is growing in recognition as a major chronic disease and a key cause of acute medical admissions. It kills approximately 30,000 patients each year in England and Wales alone, and is set to be the third commonest cause of death by 2020 globally. This pocketbook is a concise companion for all health care professionals who come into contact with patients with COPD. It covers the full spectrum of COPD management ranging from smoking cessation to advanced COPD, bridging both the primary and secondary care aspects of treatment and discussing the latest advances in our understanding of the pathophysiology and new drug treatments of this disease. This compact volume of the Oxford Respiratory Medicine Library summarises up-to-date literature in a style that will have direct clinical application to busy healthcare professionals.

Over three previous editions, Clinical Tuberculosis has established itself as an indispensable guide to all aspects of tuberculosis diagnosis and treatment. This fully revised and updated fourth edition provides practical guidance to healthcare professionals involved in any aspect of patient management or disease control; chapters are included on epidemiology, pathology, immunology, disease presentation, diagnosis, treatment and management options. The problem of TB associated with HIV infection is given special emphasis, as are the increasing problems of multi-drug resistant strains and environmentally opportunistic mycobacteria. Chapter authors have been hand-picked to represent the most up-to-date thinking in their particular subject areas, making Clinical Tuberculosis the essential reference work for the bookshelves of respiratory physicians, infectious disease specialists, public health workers and other individuals involved in the management and control of tuberculosis worldwide.

Emphasizing the urgent need to clearly understand the underlying cellular and molecular mechanisms involved in COPD, this reference provides an up-to-date perspective on the inflammatory cells, mediators, and molecular pathology of COPD.

Despite being the most common respiratory disorder in the developed world and the fourth leading cause of death in the US, chronic obstructive pulmonary disease (COPD) has received little attention compared to other lung diseases. Often it is not diagnosed until in its advanced stage. An Atlas of Chronic Obstructive Pulmonary Disease provides a vis

With nearly 1700 references, Disease Markers in Exhaled Breath is essential reading for pulmonologists; anesthesiologists; physiologists; chest, pulmonary, thoracic, and cardiovascular physicians and surgeons; asthmologists; and upper-level undergraduate, graduate, and medical school students in these disciplines. It discusses the potential diagnos

This book provides a state-of-the-art account by academic respiratory physicians and senior pharmaceutical industry personnel on the development of new drugs for asthma, allergy and COPD. It contains 80 chapters of highly condensed information, presented in an attractive, reader-friendly format with much use of tables, figures and diagrams. In addition to summarizing the diverse range of current approaches, this handbook also looks into the future, considering many topics that are promising, but have only emerged in the last few years. Developments within established drug categories such as beta-2-agonists, steroids and leukotriene antagonists are also reviewed. Never before has a single book brought together so many pharmaceutical drug developers sharing their experience on such a wide range of respiratory topics!

Includes index.

Includes index.

Includes index.