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This supplement to Transplant International contains the Proceedings of the successful 5th Congress of the European Society for Organ Transplantation held in Maastricht from 7-10 October 1991. Of 827 abstracts submitted to the congress, 548 were selected by the Scien­ tific Committee for either oral or poster presentation. Of these 548 presenta­ tions, the guest editors selected 212 full papers for publication in this book. Two aspects are important where proceedings are concerned-the quality of the papers and the speed of publication. I thank our authors and guest editors, whose combined expertise has given us a guarantee of quality. I also thank our editorial and production teams for their tremendous efforts to hasten editing, proofreading, printing, and publication. In particular, I would like to express my gratitude to Maurits Booster, M.D., and Sylvia van Roosmalen for their assist­ ance and support in seeing this supplement through to completion. As a concession to time, we have waived some of our stringent rules of style and limited our correspondence with authors by, for example, page proofs being reviewed and corrected in house only. This enables us to publish two months earlier but has the disadvantage that, given the allotted time, we have not been able to ensure that each and every article has an abstract, nor that every'i'has been dotted in the reference lists or in the addresses/institute affiliations of all the authors.

Based on the manipulations during liver allocation, this paper investigates if a potentially caused redistribution of chances to survive can be judged as a completed or attempted killing or assault to the disadvantage of an affected patient.

The 5th International Symposium on Artificial Heart and Assist Devices was held in Tokyo on January 26 - 27, 1995, bringing together leading researchers and specialists from all over the world. The proceedings of the symposium presents the newest ideas and approaches in the field, and will be of special interest and relevance to all who are concerned with artificial organs, cardiovascular surgery, organ transplantation, biomaterials, and related disciplines. Reflecting the content of the symposium, the major topics in this volume include biocompatible material development, clinical use of assist devices, completely implantable devices, and heart transplantation. These are presented in the two main divisions of the book: The first consists of eight lectures by leading researchers, world-renowned in the field of the artificial heart. The second comprises more than 50 papers on such subjects as biomaterials, research and development of ventricular assist systems and the total artificial heart, and their use as a bridge to heart transplantation. An additional, special feature of the book is the inclusion of descriptions of exhibitions at the symposium, with photographs of all artificial heart devices and systems displayed by major laboratories and companies from around the world.

Advances in Abdominal Surgery 2002 contains papers from a group of Italian academic surgeons who contribute to a national research program entitled `Progress in Abdominal Surgery'. The research is supported by the Italian Ministry of the University. The primary objective of the group is to combine experimental and clinical approaches in the study of several surgical abdominal diseases. The authors of the individual chapters were requested to present an update in their own fields of research. This volume summarizes several important updates in abdominal surgery and pathophysiology. The contributions are grouped into six sections, namely Surgical Infection, Hepatobiliary and Pancreatic and Splenic Surgery, Colorectal Surgery, Fecal Incontinence, Minimally-Invasive Surgery, and Transplantation.

In Japan, cadaveric donor liver transplantation is not common even though cadaveric organ transplantation was legally established in 1998. In contrast, the number of living donor liver transplantations is increasing, with more than 1700 cases at 43 Japanese institutes by November 2001. Indications for and have become living donor liver transplantation are widening in Japan similar to those for cadaveric donor liver transplantation in the United States and Europe. At the same time, split liver transplantation from cadaveric donors shares some technical aspects with living donor liver transplantation. Remarkable progress has been reported recently, and thus it was an auspicious time to hold a symposium on'Current issues in liver/small bowel transplantation'in Japan. We were honored to hold a very fruitful symposium sponsored by the Keio University Medical Science Fund and to bring together top-rank transplant surgeons from Japan and other countries. It was a productive and rewarding time for all participants. We were able to share our experience through excellent presentations followed by active discussions and insightful com­ ments. At the symposium, we focused on current issues in liver transplanta­ tion such as widening indications for viral hepatitis and malignant tumors. We also discussed technical aspects and physiological problems in split/iiving donor liver transplant, novel strategies in immunosuppression, and the current status and future prospects in small bowel transplantation. This book contains the papers from all the distinguished guest speakers, focusing on the topics discussed at the symposium.

A symposium,'Perioperative Management of Pacemaker Patients', was held in May 1990 at the Karl-Franzens-Universitat, Landeskrankenhaus Graz, Austria. The purpose of the symposium, organized by the Departments of Anesthesiology and Surgery, was to discuss the current status of permanent pacemaker technology, emerging developments in this field, legal issues, indications and methods for tempor­ ary perioperative pacing, and the potential for pacemaker malfunction and adverse patient-pacemaker interactions in perioperative and other medical settings. It was hoped that participants would come to some consensus concerning recommendations for satisfactory perioperative management of pacemaker patients. This symposium was probably the fIrst occasion ever that brought together representatives of the pacemaker industry, implanting physicians, and physicians responsible for the management of pacemaker patients in perioperative and other hospital settings to discuss these important matters. Certainly, it was recognized by all who attended that there existed at the time little in the way of substantial knowledge of how to best manage pacemaker patients or patients with possible indications for temporary pacing in'unique'hospital settings especially with exposure to electroma­ gnetic and other potential interference, but in the absence of professional persons with direct knowledge of pacemakers and related devices. Much new information was presented and useful ideas exchanged, so that three symposium participants were of the opinion that papers presented at this meeting should be published as a collective work.

Dieses Buch schließt unmittelbar an das „Vorgängerprojekt“ Depression, Angst, traumatischer Stress und internistische Erkrankungen (ISBN 978-3-662-65872-7) an. Ein allgemeiner Einführungsteil stellt das tragende Konzept der somatischen und psychischen Komorbidität dar und unterstreicht einen engen Zusammenhang von körperlichen Krankheiten, medizinischen, hier chirurgischen und anästhesistischen Interventionen und koexistenten depressiven, ängstlichen und (post-)traumatischen Störungen. In einem anschließenden Teil wird dieser biopsychosoziale Fokus dann auf allgemeine Aspekte von Interventionen in Chirurgie und Anästhesie in den prä-, intra- und postoperativen Abschnitten gerichtet. Diese Aspekte werden an den häufigsten Operationen in der Allgemeinchirurgie und Orthopädie veranschaulicht. Das Thema einer affektiven und Stress-bezogenen Komorbidität wird nachfolgend in einzelnen chirurgischen Spezialkontexten erneut aufgenommen, so in der Trauma- und Unfallchirurgie, der Herzchirurgie, der onkologischen Chirurgie, der Adipositaschirurgie sowie der Transplantationschirurgie. Das Buch richtet sich gleichermaßen an Kolleg•innen aus Psychiatrie, Psychosomatik, Psychotherapie und klinischer Psychologie wie auch an Kolleg•innen aus den medizinischen insbesondere den chirurgischen und anästhesistischen Fächern. Es ist auch für alle Personen von Interesse, die sich zu den komplexen psychosomatischen und somatopsychischen Themen in der Chirurgie und Anästhesie orientieren oder mit ihnen näher befassen wollen.

This innovative book provides an in-depth exploration of the legal, regulatory and ethical challenges posed by the practice of uterus transplantation (UTx) from a wide range of international perspectives.Adopting a multidisciplinary and holistic approach, the book brings together a diverse group of distinguished academics to consider the current legal and ethical climate surrounding uterus transplantation, a procedure which has been subject to increasing debate since the first UTx birth in 2014. Presenting both a comparative analysis of existing laws and regulations on UTx across the globe, and the perspectives of key academic voices on the ethical questions raised by UTx, authors tackle key issues including the right to gestate, the value of alternatives to UTx, the ethics of donor and recipient selection, child welfare concerns and public and private funding for UTx. The book also examines the future implications of UTx and potential advancements in the field to anticipate and critically evaluate the trajectory of the procedure on a wider international scale.International Legal and Ethical Perspectives on Uterus Transplantation is an indispensable resource for researchers, academics and students of health law, medical law, and human rights law. It is also a key reference point for legal practitioners, healthcare professionals, policymakers, and regulators.

The Kidney Book provides a multidisciplinary practical guide to the diagnosis and management of common kidney conditions, procedures and situations that are encountered by physicians, residents and other healthcare professionals involved in the care of patients with kidney diseases. The chapters provide point-by-point, concise and evidence-based information with tables, algorithms, and figures to summarise important clinical practices and therapeutic procedures in the daily care of patients with kidney diseases and transplants. Thence, readers will find this book easy to read and be able to quickly equip themselves with core and practically useful knowledge. This book is written by nephrologists and allied health professionals from Singapore's oldest and largest academic renal unit at the Singapore General Hospital, which has been ranked among the top 10 hospitals in the world by Newsweek.This book provides practical guidelines and information and differentiate itself from other nephrology themed books by its origin from Asia which would especially appeal to healthcare providers in the Asian region. There are very few textbooks in nephrology from Asia. In addition, it covers the most common problems and areas encountered by healthcare providers involved in the care of patients with kidney diseases in a point-by-point form which is easily digestible and extremely relevant to bedside clinical practice. The book even includes a special care section dealing with special situations and procedures such as kidney supportive care, pregnancy and therapeutic plasma exchange. This book will appeal to a wide audience and even medical/nursing or allied health students will find the book useful in their studies.

A sweeping biography of the visionary behind bone marrow transplantation and the story of the diseases cured by Don Thomas's discovery. In the last half of the twentieth century, Thomas himself discovered a cure for every marrow-based disease—like leukemia, lymphoma, and sickle-cell anemia—forever changing treatment for some of the deadliest illnesses. His feats were extraordinary, earning him a Nobel Prize, and the cascade of treatments he inspired have reshaped and will continue to reshape the practice of clinical medicine. Yet no one has ever written Thomas's courageous story. Dr. Frederick R. Appelbaum, a member of Thomas's research team, does so for the first time in Living Medicine: Don Thomas, Marrow Transplantation, and the Cell Therapy Revolution. Bone marrow transplantation has now saved over a million lives, but when Thomas first had the idea, he was met with disbelief by the scientific community. Appelbaum, informed by decades in the field and personal connection with Thomas, tells us the secrets to Thomas's success: his unique characteristics, how he created an effective team of researchers, and how he overcame the technical obstacles of marrow transplantation. Appelbaum tells a bigger story, too, of the scientific and societal implications of this achievement, which are critical for scientific and lay readers alike so that we all might be better informed of how far our medical progress has come and will go.

“[A] remarkable journey.”—The Telegraph The incredible life story of legendary cardiac surgeon and scientist Magdi Yacoub, an outsider who succeeded against the odds Veteran journalists Simon Pearson and Fiona Gorman follow the remarkable life of heart surgeon Magdi Yacoub from his formative years in Egypt, through spectacular success at Cairo University, to his long and distinguished career in Britain. Although at times he clashed with the medical establishment in London, Yacoub pioneered great advances in heart surgery. He was knighted in 1992, and in 2014, he was awarded the highest honor in the gift of the Queen, the Order of Merit.Written with unprecedented access and drawing on extensive interviews and research, the biography recounts how Yacoub transformed the treatment of children with congenital heart disease. He performed some of the first heart transplants in Britain and the first heart-lung transplants in Europe. At London's Harefield Hospital, he created the greatest heart transplant center in the world. Among his patients are men and women who are still thriving more than thirty-five years after he gave them new hope. This story is also about science, the development of new medical techniques, and a deeper understanding of how the human body works. Today, at an age when most people have long since retired, Yacoub is still pushing the boundaries of scientific understanding and surgical know-how. He is also taking heart surgery to places that until now have had little access to cardiac treatment, developing centers of excellence across Africa, including in Egypt, where his hospital in Aswan has an international reputation, and a new center is rising in Cairo.Yacoub's life is one of triumph and tragedy, success and failure, fierce criticism and high praise—it is also an enthralling journey through the worlds of scientific research and medical politics and ethics at the highest levels.

The book was envisioned by bedside nurses caring for transplant and cellular therapy patients as a way to teach novice nurses and health care colleagues about the care required for this complex patient population. The nurse authors recruited an oncology nurse practitioner, transplant physician, nurse scientist and expert in medical humanities and health studies to join the project team. The dedication of the team and the willingness of the patients to contribute to the project, has led to a unique case study approach focused on the lived experience of patients and care partner(s) during the transplant/cellular therapy journey. The case studies are unique in that they encompass a qualitative narrative developed using Interpretive Phenomenological Analysis (IPA) and the inclusion of the individual's actual medical and nursing care from their health record. At every step along the trajectory of the illness, the medications and care received are described, interspersed with the voice of the patient and care partner(s) sharing their experiences. The chapters follow the individual patients and their care partner(s) through all phases of their illness. The interviews were conducted, and case studies written by the bedside clinical nurses. Visual art and prose created by patients and care partner(s)s are included in the chapters. The book also includes an introduction written by the nurse authors, a methods chapter on the inclusion of IPA in a case study, and poignant epilogue. The premise of nursing support for survivorship is woven throughout the book, highlighting how giving back aids in recovery identity.This book, full of beautiful artworks and poems, is the work of clinical nurses devoted to improving care for their patients by sharing the patient stories with others. It introduces a unique approach to the case study which could be replicated and applied to any diagnosis.

This book introduces transplantation in rodents as useful tools used in studying transplant immunobiology. Several solid organs (kidney, heart, liver) transplant models in rodents are described in this book. It can help surgical quality and save surgical time. The first part of the book provides a review of rodent transplant tolerance induction, the role of gender and body-weight in rodent transplantation, surgical instruments and organ preservation solutions. In the second part of the book, various organ-transplantation techniques in rodents are discussed in individual chapters. This book presents uniform surgical procedures in mouse and rats, which produce comparable data, efficiently enhancing the translational research from bench to non-human primates and beyond. In this second edition, authors updates its recent progress. In addition, 3 chapters in mouse organ transplantation are added. It will be of great value to transplant researchers, research fellows and clinicians in many surgical specialties.

Concise, thorough, and easy to use, Handbook of Nephrology and Hypertension 7th Edition, provides authoritative guidance on diagnosing and treating patients with a wide range of kidney disorders and hypertension, including coverage of dialysis and transplantation. Lead editor Dr. Christopher Wilcox and his team of section editors Drs. Michael Choi, Limeng Chen, Winfred N. Williams, and Mark S. Segal oversee a group of expert authors, both faculty and fellows, who focus on common problems and challenges in this complex field. Brief, focused chapters contain abundant figures and algorithms and have been updated to reflect new findings in renal cystic diseases, new drugs used for hypertension, transplantation and renal protection, and much more.

The book provides a visual run-through of liver pathology through high-quality images from the healthy liver through acute liver injury to chronic liver disease - stressing on common mechanisms for specific histological appearances, correlating them with clinical features and laboratory investigations to reach the diagnosis. Individual chapters in this richly illustrated atlas cover the wide gamut of liver disease, including types of liver injury, viral hepatitis, fatty liver disease and its complications, vascular and autoimmune liver diseases, pediatric liver diseases, liver tumors, and finally, pathology of the transplanted liver.This book bridges the gap by integrating basic clinical information with histopathological findings, as existing books cater primarily to the pathologist's needs and do not provide sufficient clinical background to engage the clinician. It serves as a quick guide for adult and pediatric hepatologists, liver surgery doctors, pathologists as well as trainees in gastroenterology, hepatology, gastrointestinal surgery, liver transplantation and pediatric gastroenterology.

A new revision guide designed to help candidates prepare for the first part of the FRCS general surgery exam. Due to a lack of preparatory resources for the exam, this book bridges the gap, offering updated guidelines and information which will help candidates succeed. It acts as a supportive revision guide which will enrich other FRCS exam resources. This resource provides an updated approach to the FRCS exam. Using questions written by practicing surgeons, the book offers more contemporary revision materials, touching on topics not widely covered in other FRCS revision aids. Readers will gain a familiarity with the style of the FRCS exam, as Higher FRCS uses a style reflective of the exam to enhance the candidate's knowledge, confidence, and preparation. The audience for this book includes general surgery trainees who are preparing for their higher exams (including FRCS), alongside surgical trainees taking the MRCS. It is also a beneficial resource for students in other medical courses studying for surgical exams.

This volume provides a compilation of renal transplant biopsies, along with the clinical background of several interesting cases, and is a compelling read for practising nephrologists, renal pathologists, and transplant surgeons, as well as trainees in these fields. It blends the complex principles of handling and interpretation of biopsies with microphotographs and detailed descriptions. For clinicians, it will serve as a resource with which to plan treatment strategies, while it will serve as a concise and practical guide for renal pathologists.

The book covers all aspects of peri-operative anesthetic management of liver transplant patients. It provides a comprehensive coverage of the relevant history, surgeons', hepatologists', intensivists'and pediatricians'perspective of the disease, its pathogenesis, clinical presentation and indication for transplant. It discusses the practical aspects like fluid management and use of vasopressors. The book is divided into sections for a better and comprehensive delivery of information. Individual sections provide up to date information on the pre-operative issues and optimisation, intra-operative care and management and post-operative critical care issues and management of all transplant patients with special emphasis on recent advances. Separate sections cover ICU care of these patients in great detail and anesthetic management of pediatric liver transplant. The book includes anesthetic techniques involved in conducting multiorgan transplant. It discusses clinical approach toa patient with acute liver failure, brain death criteria and laws and organ donor management. It also presents newer techniques and methodologies adopted in the field of liver transplant. It includes ample illustrations, flowcharts, key points in each chapter, figures and photographs. The book contains chapters focusing on post-transplant patients presenting for non-transplant surgery. The book fills the gap in the literature for a comprehensive guide for the anesthetist performing or pursuing liver transplant, students/trainees/examinees who have a keen interest in this field and doctors dealing with such patients in critical care, donor management, pursuing general anesthesia. It is also helpful for hepatologists, intensivists and surgeons associated with liver transplant.

When Joseph Murray performed the first successful living kidney donor transplant in 1954, he thought this would be a temporary stopgap. Today, we are no closer to the goal of adequate organ supply without living donors--if anything, the supply-demand ratio is worse. While most research on the ethics of organ transplantation focuses on how to allocate organs as a scarce medical resource, the ethical treatment of organ donors themselves has been relatively neglected. In The Living Organ Donor as Patient: Theory and Practice, Lainie Friedman Ross and J. Richard Thistlethwaite, Jr. argue that living donor organ transplantation can be ethical provided that we treat living solid organ donors as patients in their own right. Ross and Thistlethwaite develop a five-principle framework to examine some of the attempts to increase living donation. It uses the three principles of the Belmont Report: respect for persons, beneficence, and justice modified to organ transplantation, as well as the principles of vulnerability and special relationships creating special obligations. Their approach requires that the transplant community fully embrace current and prospective living organ donors as patients to whom we have special obligations. Only when living organ donors are regarded as patients in their own right and have a living donor advocate team dedicated to their well-being can the moral limits of living solid organ donation be realized and living donors be given the full respect and care they deserve.

This is a comprehensive translational reference covering a range of topics within heart transplantation. Including review of the procedure itself, preoperative requirements, potential complications and follow-up with the most up-to-date research and literature review, it introduces the embryology, anatomy, physiology, pathology and cardio-immunology of the heart. It also delves into other aspects of heart transplantation including organ procurement, religious aspects, the ethical issues that can emerge prior or during the surgery and discussion of the continued development of artificial hearts. The book explores multiorgan transplantation and their outcomes and complications.Heart Transplantation discusses the topic using illustrations and charts to aid understanding, allowing readers to gain a full understanding of the whole procedure easily. A list of practical surgical questions are presented at the end of each chapter to encourage the reader to challenge theirunderstanding of the topic. With an emphasis on an interconnected approach to studying heart transplantation, this book presents a novel approach to educating surgeons in this challenging area of surgery. It is therefore an important addition to the literature for all involved in the management of heart transplantation from surgical residents to surgical nurses, cardiologists, anesthesiologists and experienced cardiac surgeons.

This unique book details a multidisciplinary approach for providers caring for the Mechanical Circulatory Support (MCS) patient. Authors discuss the history of MCS, patient selection, surgical and post-operative care, mobility and nutritional issues for this subgroup of patients, along with outpatient management. They are expert clinicians in the field of MCS and Extracorporeal Membrane Oxygenation (ECMO), who provide direct patient care, conduct research, publish and maintain current leadership positions within the International Society of Heart and Lung Transplant and International Consortium of Circulatory Assist Clinicians.Non-clinical issues including Regulatory, Reimbursement, Administration, Program Development and links to Professional Organizations supporting MCS Clinicians are presented in the book that will be of great value to Nurses first, but also to Advanced Practice Providers (NP/PA), Dieticians, Physical Therapists and Administrators.

This book provides a comprehensive yet accessible look at organ donation and transplantation, including coverage of scientific, medical, social, legal, and ethical issues. Readers will also discover how new technologies and medical advances are shaping the future of organ donation.Donated organs and tissues have improved or saved the lives of hundreds of thousands of individuals. But these life-changing procedures raise many logistical and ethical questions. How can organs be effectively allocated to those in need? Should individuals be allowed to purchase organs from living donors? What role does religion and culture play in someone's decision to donate or accept an organ? Will new technologies like bioprinting change the future of organ donation?Part of Greenwood's Health and Medical Issues Today series, Organ Donation is divided into three sections. Part I explores different aspects of the donation and transplantation process, including which tissues and organs can be donated, living versus deceased donation, religious and cultural perceptions, and cutting-edge alternatives to traditional organ transplants. Part II delves deep into a variety of issues and controversies related to the subject, offering thorough and balanced coverage of such hot-button topics as opt-in versus opt-out systems, organ trafficking, and transplant tourism. Part III provides a variety of useful materials, including case studies, a glossary, and a directory of resources.

Cardiopulmonary Transplantation and Mechanical Circulatory Support provides a comprehensive review of the field. Written for all tiers of healthcare professionals managing such complex patients. The handbook tackles all topics within this field, including heart failure, heart transplantation, lung transplantation, and all tiers of mechanical circulatory support in adults and paediatric patients. The chapters are written by prominent and globally respected experts in Europe and North America, providing their evidence base as well as personal, practical hints and tips for all practitioners.

Bile duct injuries (BDI) are considered the most serious surgical complication associated with cholecystectomy. According to different reports, its incidence has remained constant over the years, ranging from 0.1% to 0.9%. BDI is associated with a greater risk of perioperative morbidity and mortality, a reduction in the quality of life, and a decrease in long-term survival. Also, this complication is a concern to surgeons since its progression is uncertain and may lead to demands on professional responsibility ('malpractice') and emotional and physical consequences ('second victim').Given that injuries in a high percentage of patients are initially unsuspected, the postoperative recovery may be prolonged, and the possibility of a successful repair reduced. Several surgical, endoscopic, and percutaneous procedures may be necessary to manage the lesions and to treat coexisting complications. BDI patients often undergo several repair attempts before successful resolution. This affects their quality of life and has a high psychological, physical, and mental impact due to the prolonged, complex, and unexpected nature of the injury. This currently represents a frequent problem in specialized referral centers or hepatobilopancreatic surgery units, where patients arrive with the sequelae of previous inadequate treatments. Usually, these patients require more elaborate procedures such as reoperations, liver resections and liver transplantation. The prevention, early diagnosis, and adequate treatment in the first approach is of crucial importance to ensure good long-term results. Therefore, this book is an essential resource for surgeons who perform cholecystectomy or treat BDI patients. It provides practical information and a comprehensive review on prevention and proper management, including complex cases. Readers will find contributions by experienced authors from a multidisciplinary and reference team in the management of BDI patients.

In a community hospital in suburban Chicago run by Catholic nuns, surgeons performed an operation never done in the world before. The team at the Little Company of Mary Hospital led by Richard Lawler transplanted a kidney in 1950 from a just-deceased woman into the abdominal cavity of a 44-year-old woman. Critics in the medical community called the operation irresponsible because immunosuppressant drugs that prevent the rejection of a transplanted organ had yet to be developed. Some Catholic clergy considered the transplant sacrilegious because it “desecrated” the sacred body of a dead woman when her kidney was removed. Yet the nuns who ran the hospital blessed the procedure. Lawler said time alone would judge its success. Seventy years later, that transplant is largely lost to history—overshadowed by remarkable transplant surgeries and medical breakthroughs that have made life-saving kidney and other organ transplants almost routine. The book throws light on a seminal moment in medical history, offering new insights into the early days of human organ transplantation while also looking at the current national kidney crisis.

While the physical and emotional trials of waiting on transplant lists are featured in popular media, the struggles recipients face years after surgery are not. Voices of Teenage Transplant Survivors introduces illness narratives from an unrecognized patient population: recipients of heart, liver, and kidney transplants. Offering unique narratives by adolescents who use poetry to explore issues surrounding the changing body, independence, identity, and mortality, the book showcases a message of healing and voices of hope amid uncertainty. Illuminating the physical, psychological, and existential challenges confronted by adolescents for which organ rejection and side effects loom in their future, Sample details the poetry workshops where these adolescents articulated experiences silenced by family, friends, and the culture of medicine. She includes close readings and analyses of their writings, along with writing prompts and references to narrative medicine theory. This powerful book offers something new for medical and health professionals, medical humanities researchers, students, and the public.

Comprehensively addressing the topic of the compartment syndrome, this book covers all aspects of this painful and complex condition, ranging from the history to the pathophysiology and treatment in the various body compartments affected by the syndrome, as well as the short- and long-term outcomes. With an up-to-date literature review and the innovative content written by international opinion leaders, it offers all involved in the management of such complicated patients a much-needed source of reference.Discussing compartment syndrome in everyday practice, this book is of interest to surgeons, practicing physicians, anesthesiologists and nurses.

This book provides a complete guide to the evaluation, care, and follow-up of living kidney donors. Living donor kidney transplantation is established as the best treatment option for kidney failure. However, despite the tremendous benefits of living donation to recipients and society, the outcomes and optimal care of donors themselves have received relatively less attention. Fortunately, things are changing – including recent landmark developments in living donor risk assessment, policy and guidance. This volume offers authoritative, evidence-based guidance on the full range of clinical scenarios encountered in the evaluation and care of living kidney donors. The approach to key elements of risk assessment, ethical considerations and informed consent is accompanied by recommendations for patient-centered care before, during, and after donation. Advocacy initiatives and policies to remove disincentives to donation and advance a defensible systemof practice are also discussed. General and transplant nephrologists, as well as related allied health professionals, can look to this book as a comprehensive resource addressing contemporary clinical topics in the practice of living kidney donation.

This book introduces the clinical application of artificial liver system (ALS) in hepatic failure. It has been widely used in clinics aiming to provide temporary support of liver function while maintaining extra-hepatic function in patients with liver failure. This work comprehensively summarizes the progress of livers and artificial liver, for example, the principle and implementation of Li-ALS, cell transplantation and the combined application of artificial liver and liver transplantation. It will be helpful for clinicians to implement artificial liver treatment to save the lives of patients with hepatic failure.

This collection features comprehensive overviews of the various ethical challenges in organ transplantation. International readings well-grounded in the latest developments in the life sciences are organized into systematic sections and engage with one another, offering complementary views. All core issues in the global ethical debate are covered: donating and procuring organs, allocating and receiving organs, as well as considering alternatives. Due to its systematic structure, the volume provides an excellent orientation for researchers, students, and practitioners alike to enable a deeper understanding of some of the most controversial issues in modern medicine.

This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant and cellular therapy patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook begins by providing a general overview of stem cell transplantation and goes on to outline disease-specific indications for stem cell transplantation. It then focuses on transplant complications and ongoing care, and finally explores cellular therapies for hematologic malignancies.Comprehensive and easy-to-use, Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care, Third Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers as well as residents, fellows, and other trainees who care for patients who undergo transplant and immune effector cell therapy.

This disorder transcends multiple disciplines and demands a team approach to improve knowledge and treatment. The highly experienced internationally recognized authors have updated every section and added many new chapters, including some on genetic abnormalities in virus and host seen in PTLDs. In this successor edition, there is a completely new section on PTLDs after hematopoietic stem cell transplantation. The newest PTLD classifications and current treatment paradigms that reflect recently conducted international trials are fully incorporated. As technologies have advanced, this book provided state-of-the-art new diagnostic and prognostic information.Post-Transplant Lymphoproliferative Disorders 2nd Edition is designed to be a valuable reference for oncologists and all transplant professionals, such as surgeons, nephrologists, cardiologists, hepatologists/gastroenterologists, pulmonologists, infectious disease specialists, pathologists, as well as interns and residents in training in these specialists. It provides these professionals with comprehensive and up-to-date information that guides their management of transplant patients before and after transplant, with and without PTLD.

This concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved in terms of blood-loss reduction, fast tracking and reduced risk. The book also addresses anesthetic aspects in connection with the recently introduced and rapidly expanding practice of laparoscopic surgery; with enhanced recovery; and with pancreatic surgery. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation is intended for aspiring HPB and transplant anesthetists, anesthesia trainees, and consultants with experience in HPB anesthesia who want to see whether or not they're up to date on the current standards.

This book has 20 chapters which cover a full range of knowledge about liver anatomy before one embarks on carrying out a liver operation on a patient. The knowledge ranges from external to internal anatomy of the liver, from pure anatomy to its application in liver operations, from vascular infiow/outflow of the liver to techniques used in reducing intraoperative blood loss, from Couinaud's liver segments to segment- based liver resection, and from the different approaches to liver resectional techniques to the different types of liver transplantation. The particular feature of this book is the heavy use of diagrams which makes reading easier. Surgeons in liver resection and liver transplantation in will find this book of value as a reference book.

Rikki and her sister, Linda, fell out with one another four months ago. They are not speaking when Linda emails that she has lethal abdominal tumors, that her only hope of survival is a total bone marrow replacement. Linda claims Rikki is too old to donate, and explains there's only a slight chance she is a good match anyway—but Rikki refuses to accept that. Despite the wounding between them, Linda's email ignites a wild aspiration in her sister: she will become the perfect donor, the perfect match, with the healthiest, most vigorous cells possible. She rises with intent to heal herself, her sister, and their rootlines, the patterns formed in their family of origin that have quietly shaped their lives. Rikki walks through the science while confronting dogma that limits how mind can transform body. She builds herself into a stem cell factory using Muay Thai kickboxing and vegetarian nutrition. Working through childhood wounds and mental limits with meditation and yoga, she finds her own power, as well as ways to show up for Linda and walk with her from the edge of death to a new life. Together, the two sisters beat the lymphoma—and, as they rediscover the intimacy and love of their innocent childhood, heal the intertwined roots of their family pain.

Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals.This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic sciencebehind it. The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies, which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.

This book is designed to present a comprehensive and state-of the-art approach to all aspects of geriatric surgery within the broad confines of surgery in geriatrics including general surgery, neurosurgery, thoracic surgery, vascular surgery, cardiac surgery, surgical oncology, hepatobiliary and transplant surgery, plastic, colorectal, orthopedic, gynecologic, and urologic surgery. The text is split into four parts. The first part is organized under general considerations on the geriatric surgical patient and includes current trends in geriatric surgery, and a number of important general issues such as practical approaches to reversal of bleeding/anticoagulation, role of anesthetic concerns in advanced age, frailty index and measurements of physiological reserves, nutritional support in the elderly, quality of life in the elderly, drug use, and family involvement. Part two of the book focuses on surgery specific system-based problems in geriatric surgical patients. The third part addresses many other important aspects of geriatric surgery including palliative and end of life care for the elderly, religious issues and the elderly care surgery, elderly with mental health issues, and nursing care of elderly patients. The fourth and final part describes the need for geriatric surgical care education and the components that are essential for the curriculum of current and future generations of students. Written by experts in the field, Surgical Decision Making in Geriatrics addresses patient selection, pre-operative considerations, technical conduct of the most common operations, and avoiding complications.

In the past, liver resections and liver transplantations were performed by different surgical teams, with very little interplay between the two. However, the evolution toward more complex operations called for an increasingly intense interaction between these surgical techniques: split liver and living donor liver transplantation have become popular in the transplant community, utilizing the Coinaud segmental anatomy in a very sophisticated way, while portal and arterial resection and reconstruction have become indispensable methods for treating Klatskin tumors infiltrating the hepatic hilum. This book offers a complete overview of the connections between liver transplantation and hepatobiliary surgery. It focuses on ex situ techniques for resection of tumors at the suprahepatic confluence, with or without venous reconstruction, and on total vascular exclusion of the liver with the aid of a venovenous bypass that should be a surgical option for referral centers in hepatopancreatobiliary surgery. By taking into consideration the development of minimally invasive liver surgery, it will introduce readers to a variety of new perspectives such as: vascular exclusion techniques with or without extracorporeal circulation, hemodynamic implications and lessons learned from liver transplant surgery, and technical details on pediatric transplantation and its informative role in modern biliary tract surgery.

This book offers a comprehensive overview of liver failure including Epidemiology, mechanism of the disease, and its clinical manifestations. The diagnosis of numerous types of liver disease leading to liver failure; with specific emphasis on the current and future treatment modalities including up-to-date and extensive information on liver transplantation. It provides the most up-to-date information on liver failure for clinicians, practitioners including GPs, scientists/researchers, postgraduates and allied health professionals. It features an overview of the relevant classification and epidemiologic aspects of acute liver failure along with a thorough review of the mechanisms associated with acute liver failure and multisystemic involvement. Detailed guidance is also provided on the latest treatment techniques including those available for liver transplantation and potential future approaches, enabling the reader to develop a detailed understanding of the topic. Liver Failure: Acute and Acute on Chronic provides a practically applicable guide to the epidemiology and management of liver failure. It features contributions from an outstanding panel of experts in hepatology, gastroenterology and surgery making it a vital up-to-date reference for trainee and practicing medical professionals in a variety of disciplines who encounter these patients.

Discusses the structure and function of the cornea and external eye and reviews relevant examination techniques. Includes the latest statistics on indications for corneal transplants from the Eye Bank Association of America. Covers infectious and ocular surface diseases; disorders and surgery of the ocular surface; immune-mediated and neoplastic disorders; and congenital anomalies and degenerations. A chapter on the genetics of corneal dystrophies reflects the IC3D classification. Toxic and traumatic injuries and corneal transplantation are also reviewed.

In 1970 American neurosurgeon Robert White and his team carried out the first full head transplant in living monkeys. However, the resulting chimera was left tetraplegic and died a few days later. Fifty years on, the technology to perform a human cephalosomatic anastomosis is finally available. In this groundbreaking book, the pioneers of this new medical frontier bring together an international team of scientists to reveal for the first time the entire body of animal and human research and experimentation that made this breakthrough possible. Readers – professionals, journalists, educated laypersons- will get unadulterated access to the published and unpublished body of evidence that has shocked the world since 2013. Only a deep appreciation of this technology can inform the ethical debate that has raged since 2013. Above all, the possibility of extending life raises profound dilemmas. This book brings clarity to the current debate and provides the instruments to make an informed decision on the most sensitive of subjects: overcoming death.

This book presents the first comprehensive review of all facets of liver transplantation using DCD donors. Each of the 19 chapters are written by leading experts in the field, representing some of the most experienced DCD liver transplant programs in the world. Several topics have overlapping coverage in different chapters, providing the reader with the perspective of multiple experts on crucial topics. Chapters also highlight the steps towards building a DCD liver transplant program, the importance of donor and recipient selection, as well as state-of-the-art developments and future directions in the utilization of these organs.Donation after Circulatory Death (DCD) Liver Transplantation serves as a valuable resource for all those involved in liver transplantation using DCD donors.

For the surgeon of antiquity the liver has been an organ of mystery – and danger. Attempts to repair its wounds or remove tumors were fraught with hemorrhage and often a fatal outcome. Most forays were those to remove easily accessible tumors on the liver edge, but bleeding was a feared consequence still and surgeons wielded a plucky fortitude to take on even those. Not until the mid-20th Century were surgeons able to safely excise neoplasms that lay deep within the liver substance. Jean-Louis Lortat-Jacob achieved notoriety in his famous Paris hepatectomy of 1951 but he was not the first. That distinction may have belonged to German Professor Walther Wendel in 1910 or to Japanese surgeon Ichio Honjo who reported his operation in 1950, but in Japanese. It was not picked up by the Western surgical community until 1955. Names such as Hugo Rex, James Cantlie, Jean-Louis Lortat-Jacob, Tôn Thất Tùng, Jacques Hepp, Claude Couinaud, Henri Bismuth, Thomas Starzl, Roy Calne, and a host of others highlight the extraordinary curiosity, tenacity, and skill of those surgeons who broached unknown territory to master understanding and techniques of manipulation, resection, and transplantation that were formerly considered unapproachable by the surgical world.

The evolution of medicine is one of the outstanding features of the past century. The progress achieved by organ transplants is particularly important in this regard. Transplant medicine has progressed massively, but, due to insufficient social donation responses, waiting patient lists increase and the sad consequences of this reality persist indefinitely. This book provides a thorough analysis of the problems presented by organ transplants and social behaviour. It interprets the evolution of transplantation, and its associated medical, ethical-legal, psychosocial and religious problems, as well as educational proposals that have accompanied this medical practice over time. It will serve to provide, at all societal levels, the possibility of a clear understanding of this serious health crisis.

Offering practical guidance for all members of the transplant team, Kidney Transplantation, Principles and Practice, 8th Edition, provides the balanced, up-to-date information you need to achieve optimal outcomes for your patients. A global team of internationally renowned surgeons and nephrologists, many new to this edition, offers fresh perspectives on everything from applied science and surgical techniques to immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, in both adults and children. - Offers state-of-the-art coverage of all areas of kidney transplantation such as preservation of kidneys; mechanisms of rejection and the induction of tolerance; techniques of laparoscopic live donor nephrectomy; and immunosuppression. - Contains up-to-date outcomes data and analysis of the evidence supporting current practice in the field. - Includes new information on desensitization and considerable new data on the clinical use of costimulation blockade. - Keeps you current with new chapters on kidney allocation policy that reflects the ethical and societal values of different countries and populations; and biomarkers of kidney injury and rejection, including the need for better monitoring tools to guide therapy and patient management. - Covers hot topics such as management of chronic allograft failure, the sensitized patient and antibody-mediated rejection, and paired exchange principles. - Features hundreds of superb illustrations to help you visualize key concepts and nuances of renal transplantation. - Provides dynamic visual guidance with new real-time video coverage of ultrasound-guided pancreas allograft biopsy; a new animation of calcineurin inhibitor mechanism of action animation; and videos that demonstrate the formation of an immune synapse, 3-D rotational images of immune synapses, an NK cell killing its target, peritoneal dialysis-catheter insertion techniques, laparoendoscopic single site (LESS) donor nephrectomy, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

This book discusses all aspects of the uterus transplantation procedure in women who are childless because of a dysfunctional or missing uterus, from initial pre-operative investigations to follow-up after the uterine graft has been removed. All the international experts who are engaged in clinical activities and/or research in this field have contributed one or more of the book's chapters. Since the first live birth following uterus transplantation was reported in Sweden in September 2014, the field has been rapidly evolving around the globe: the first cases in USA, Germany, China, Brazil, and Czech Republic were performed in 2016 and several other centres are preparing for clinical trials of uterus transplantation. Uterus transplantation is a subject that attracts the attention of many bioethicists, and like all other major procedures in transplantation surgery and assisted reproduction techniques, it is a complex process that requires a multidisciplinary team if it is tobe successful. As such the book is a valuable resource not only for clinicians from many disciplines, but also for nurses, ethicists, psychologists and researchers.

This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation. The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation. This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.

Against a global backdrop of wartime suffering and postwar hope, Borrowing Life gathers the personal histories of the men and women behind the team that enabled and performed the modern medical miracle of the world's first successful organ transplant.'An extraordinary work. Shelley Fraser Mickle has not only provided a detailed, fascinating documentation of the world's first successful organ transplant, but she has also painted the lives of those involved--doctors, patients, family members--so vividly that the reader is completely enthralled and emotionally invested in their grieved losses as well as their successes. The result is a beautiful tribute to medical science as well as to humanity.'Jill McCorkle, NYT bestselling author of Life After Life'Working with Dr. Moore, Dr. Murray and Dr, Vandam to create the painting commemorating their historic operation and the research leading up to it was the greatest adventure of my artistic career. Having my painting on the cover of Borrowing Life renews that excitement, for I know what grand adventure is waiting for the reader.'Joel Babb, artist'I was so very pleased to be involved with Shelley as she wrote her captivating, compelling book. I only wish that Ron could be here with me to read it.'Cynthia Herrick, wife of the first successful organ transplant donor'Had these men and women not worked diligently to save the life of Charles Woods, I and my 5 brothers and 3 sisters, would not have been born. Charles Woods and Miriam Woods are my parents. It is thrilling to read Ms Mickle's book as it closely mirrors the stories our dad and mom shared with us as children. The amazing thing is that as a disfigured war hero, our dad embraced his appearance as a badge of honor.'David Woods Performed at Boston's Peter Bent Brigham Hospital in 1954, the first successful kidney transplant was the culmination of years of grit, compassion, and the pursuit of excellence by a remarkable medical team--Nobel Prize-winning surgeon Joseph Murray, his boss and fellow surgeon Francis Moore, and British scientist and fellow Nobel laureate Peter Medawar. Drawing on the lives of these members of the Greatest Generation, Borrowing Life creates a compelling narrative that begins in wartime and tracks decades of the ups and downs, personal and professional, of these inspiring men and their achievements, which continue to benefit humankind in so many ways.

Intestinal transplantation remains on the cutting edge of solid organ transplantation. Each potential recipient provides a unique case of intestinal failure with individual intricacies requiring the combined efforts of a complex multidisciplinary team in order to achieve success. Contemporary Small Bowel Transplantation covers all aspects of intestinal transplantation in a manner accessible to all providers and provides specific guidance for those that may come in contact with this field and these patients. The text provides an understanding of the critical pre-operative evaluation, thorough descriptions of each surgical procedure and postoperative management. Areas such as infectious disease, nutrition and graft versus host disease will be addressed in detail. Key controversies and administrative issues unique to intestinal transplantation are covered. Contemporary Small Bowel Transplantation provides critical guidance for the new transplant surgeon, gastroenterologist or administrator as they navigate the challenging field of intestinal transplantation.

This comprehensive volume provides a platform from which both major and minor infectious diseases related issues are addressed in-depth among this highly susceptible population. The book begins with an overview of infections in various modalities. This is followed by chapters on clinical disorders, etiologic agents, therapeutics, and infection prevention. Chapters include easy-to-follow figures and tables, radiologic images, and pictorial demonstrations of various disease states to familiarize and reacquaint the transplant clinicians and surgeons in practice and training, and those belonging to subspecialties providing supportive care for these patients. Discussions to enumerate the noninfectious causes that mimic infectious diseases; clinical relevance and effective utility of existing and emerging diagnostic tools are presented throughout the book. Authored by leaders in their fields, this book is the go-to reference for management of patients undergoing hematopoietic and solid organ transplantation.