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Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts addresses contemporary debates on herbicide toxicology. The reader is offered a comprehensive overview of this complex topic, presented by internationally recognized experts. Information presented will inform discussions on the use of herbicides in modern agricultural and other systems, and their potential non-target effects on human populations and various ecosystems. The book covers these matters in concise language appropriate to engage both specialists in the research community and informed persons responsible for legislative, funding, and public health matters in the community at large. The use of herbicides is an essential pillar of modern agricultural production systems. Weeds, if uncontrolled, would reduce crop yield and result in massive economic damage. Recently, the heavy reliance on single herbicides has been linked to the development of weed resistance. To combat resistant weeds, farmers are advised to use a mix of several herbicides and to increase herbicide application rates. As a result, the toxicity of herbicides on human health and the environment has become a controversial topic. - Offers a comprehensive overview of herbicide science in modern agricultural systems - Addresses the complex problems that can arise from herbicide use and misuse, including weed resistance, pollution, and human health issues - Uses recent examples to demonstrate the topical nature of this issue

The development of chemicals to selectively control the growth of weeds has been a fascinating success story which has unfolded largely during the last four decades. The dramatic growth of herbicide research that followed the wartime discoveries of the auxin-type herbicides (phenoxyalkanoic acids) resulted in a whole range of compounds and mixtures which are used to eliminate broad-or narrow-leaved weeds from agricultural, horticul­ tural, or forestry crops. Today, the safe use of this armament of compounds requires our understanding of their mode of action, metabolism, and environmental persistence. The most recently developed herbicides are highly effective inhibitors of specific enzyme systems, and formulation may be an important factor determining their efficient delivery at specific target sites. In this book, the major target sites of herbicide action are discussed in Chapters 1-5, with particular reference to photosynthesis; amino acid, lipid, and carotenoid synthesis; and other primary target sites. The effects of synergists or antagonists as modifiers of herbicide action are described in Chapter 6. The importance of efficient target site delivery as a fundamental factor in herbicide activity and selectivity is generally recognized. Delivery of a potentially lethal dose of active ingredient may depend on a whole range of factors including the efficiency of application, retention, absorption, translocation, immobilization, and detoxification. These aspects are con­ sidered in the remaining chapters, with particular reference to the pathways and mechanisms involved in the uptake, translocation, and metabolism of soil-and foliage-applied herbicides.