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Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches. The book links complex immunological processes with computational analysis and emphasizes the importance of immunology to the mammalian system.

Natural Cell-Mediated Immunity Against Tumors aims to be the first book to provide a comprehensive discussion on natural cell-mediated immunity against tumors. This book is mostly a collection of different research contributed by leading laboratories. It also presents a better perspective of how natural mechanisms fit in with and relate to the traditional and more extensively studied components of the immune system. The book starts off with an overview of the contents of the volume – the historical development of the advances in the field of research and the status of knowledge in the subject area. Divided into four major sections, the book consists of a total of 98 chapters. The sections discuss the natural killer cells and related cells and the natural lymphokine production. This book also explains the natural macrophage and granulocyte cytotoxicity. The book will be a helpful reference for students, professionals, and researchers in biology, immunology, biochemistry, microbiology, and other related fields.

Immune Recognition and Evasion: Molecular Aspects of Host-Parasite Interaction reviews recent advances in understanding the genetic basis of host-parasite interactions, with emphasis on antigenic epitopes, the genetics of parasites, the molecular mechanisms of immune recognition and evasion, and the way that cytokines and hormones act on host-parasite interactions. Organized into four parts encompassing 25 chapters, this volume begins with an overview of the genomic organization of the T cell receptor genes and the contribution of non-B DNA structures to switch recombination in immunoglobulin genes. It then discusses signal transduction by class II molecules encoded by the major histocompatibility complex la and the biological consequences of this process; allelic polymorphism of HLA class II antigens and its connection to the molecular basis of autoimmunity; mimicry between HLAB27 and bacteria; and genetic control of susceptibility to helminth infection. The reader is also introduced to recognition of protein antigens by antibodies; recognition of influenza antigens by class I-restricted cytotoxic T lymphocytes; the biochemical basis of cachexia of infection; mechanisms of antigenic variation in Plasmodium; and rational design of trypanocidal drugs. Geneticists and molecular biologists will gain valuable information from this book.