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Microbial Xylanolytic Enzymes describes the enzyme structure and its interaction with plant cell walls, the properties and production of different enzymes and their applications, and the knowledge gathered on the hydrolysis mechanism of hemicellulose. The knowledge gathered about the hydrolysis mechanism of the hemicelluloses, especially xylans, has greatly promoted the rapid application of these enzymes in new areas. In recent years, there has been a spurt of interest in xylan degrading enzymes due to their applications in several industrial processes, including paper and pulp industries, food and feed industries, biofuel industry, textile industry, chemical and pharmaceutical industry, brewing industry, and more. Xylan is the principal type of hemicellulose. An enzymatic complex is responsible for the hydrolysis of xylan, but the main enzymes involved are enzymes produced by fungi, bacteria, yeast, algae, protozoans, and more. Gives up-to-date authoritative information and cites pertinent research on the synergistic action of xylanolytic enzymes Includes studies on xylanase regulation and synergistic action between multiple forms of xylanase Covers, in great depth, all aspects of Xylanolytic enzymes Includes detailed descriptions on Xylanolytic enzymes as a supplement in animal feed, for the manufacture of bread, food and drinks, textile industry, pulp and paper industry, biofuel industry and production of pharmaceuticals and important chemicals and waste management, etc. Challenges future trends in the commercial production and application of xylanases

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications, Volume 185, Part A represents the collation of chapters written by eminent scientists worldwide. Chapters in this updated release include An introduction to microfluidics and their applications, Design and fabrication of Micro/Nanofluidics devices and systems, Detection and separation of proteins using Micro/Nanofluidics devices, Micro/Nanofluidics devices for DNA/RNA detection and separation, Paper based microfluidics a forecast towards the most affordable and rapid point-of-care devices, Paper based micro/Nanofluidics devices for biomedical applications, Advances of Microfluidics Devices and their Applications in Personalized Medicine, and much more. Additional chapters cover Microfluidics for single cell analysis, Fluorescence Based Miniaturized Microfluidic and Nanofluidic Systems for Biomedical Applications, Active Matter Dynamics in Confined Microfluidic Environments, Challenges and opportunities in micro/nanofluidics and lab-on-a-chip, and Paper-microfluidic signal-enhanced immunoassays. Offers basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab-on-chip Explains how to develop microfluidics/nanofluidics for biomedical application such as high throughout biological screening and separation Discusses the applications, challenges and opportunities in biomedical and translational research applications of microfluidics/nanofluidics

Glycoside Hydrolases provides a detailed overview of the biochemical, biophysical, and protein engineering properties of glycoside hydrolases, a class of enzymes in growing use across various applications. Here, more than a dozen global experts discuss the structural and catalytic mechanisms of specific glycoside hydrolases, followed by their implications in biotechnological applications of different industrial sectors such as the food and feed industry, paper and pulp industry, the bioenergy sector and the pharmaceutical industry. Authors consider how the application of glycoside hydrolases may boost industrial production of valued products, and the broader environmental and sustainability goals of converting agrowaste into valued products. This book helps researchers and students across industry and academia gain deep knowledge of glycoside hydrolases, to advance new experimental research and applications from biofuel to drug discovery. Details glycoside hydrolase classification, enzyme assays for biochemical characterization, and biophysical methods for structure determination and catalytic mechanisms Discusses the use of glycoside hydrolases across various applications from biofuels to drug development, enzyme technology, and fermented food production Features chapter contributions from international leaders in the field

Volume Electron Microscopy (vEM), Volume 177 is a collective term for a set of three-dimensional high-resolution ultrastructural imaging techniques that have delivered new insights into biological systems in recent years, garnering substantial interest in the life and clinical sciences. In this book, users will find a variety of vEM workflows and technologies, highlighting application areas with biologically relevant examples. Topics covered include Automated large volume sample preparation for vEM, Resin comparison for Serial Block Face Scanning Volume Electron Microscopy, Immunolabelling for SBF-SEM, Electron Microscopy in Plants, Serial section electron tomography, Automated Tape Collecting Ultramicrotomy (ATUM) for targeting neuropathology, Array tomography, and much more. Other sections focus on Mitochondria morphometry in 3d datasets of mouse brain obtained with serial block-face Scanning Electron Microscopy, Serial Block-face Scanning Electron Microscopy of Schmidtea mediterranea, Correlative multiscale microCT-SBF-SEM imaging of resin-embedded tissue, Methods of enhanced FIB-SEM sample preparation and image acquisition, Functional characterization of endo-lysosomal compartments by correlative live-cell and volume electron microscopy, and much more. Includes chapters written by key leaders and developers in the field Provides detailed protocols, allowing for the application of workflows in one's own laboratory setting Presents real tips and tricks you won't get from standard research papers

Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will be a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in understanding more about how to process and apply great amounts of data to improve their research. Includes at each section resource pages containing a list of available curated raw and processed data that can be used by researchers in the field Provides demonstrative and relevant examples that serve as a general tutorial Presents a list of algorithm names and computational tools available for basic and clinical researchers

Enzymes as Sensors, Volume 589, the latest release in the Methods in Enzymology series, covers a variety of topics, including advances in genetically coded fluorescent sensors, enzymes as sensors, and bioapplications of electrochemical sensors and biosensors. Users will find a comprehensive discussion of timely topics that presents a micro-level delivery of specific content related to the study of enzymes in sensors. New to this edition are highly specialized chapters on integrated strategies for gaining a systems level view of dynamic signaling networks, sensitive protein detection and quantification in paper-based microfluidics for point-of-care, and microneedle enzyme sensor arrays for continuous in vivo monitoring. This state-of-the-art series is ideal for those interested in the latest information on enzymology, with this edition focusing on sensors and their role in enzymes. Contain contributions from leading authorities Informs and updates on all the latest developments in the field

Advances in Marine Biology, Volume 97, the latest release in this serial that highlights new advances in the field, including comprehensive chapters written by an international board of authors.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Advances in Marine Biology series

Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 PART B focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more.Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoid dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more.Provides detailed articles regarding how to study the structures and mechanisms of mononuclear non-heme iron dependent enzymesGuides readers on how to use partner proteins in non-heme iron enzyme catalysisIncludes strategies to employ mononuclear non-heme iron enzymes in biocatalytic applications

A Practical Guide to Planning, Writing, and Reviewing Medical Device Clinical Evaluation Reports guides readers through clinical data evaluation of medical devices, in compliance with the EU MDR requirements and other similar regulatory requirements throughout the world. This book brings together knowledge learned as the author constructed hundreds of CERs and taught thousands of learners on how to conduct clinical data evaluations. This book will support training for clinical engineers, clinical evaluation scientists, and experts reviewing medical device CERs, and will help individual writers, teams and companies to develop stronger, more robust CERs.Identifies and explains data analysis for clinical evaluation of medical devicesTeaches readers how to understand and evaluate medical device performance and safety in the context of new regulationsProvides analysis of new clinical evaluation criteria in the context of medical device design as well as in-hospital deployment and servicing

Hormones, Volume 142, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Estrogen receptor binding mechanism with agonist and antagonist, Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment Studies – A Bioinformatics approach, Exploring the Role of Estrogen and Progestins in Breast Cancer: A Genomic Approach to Diagnosis, Structural insights on ER-alpha, ER-Beta, progesterone and their drug-targets interactions in Breast cancer, The predictive ability of myokines in patients with chronic heart failure, and much more.Other chapters cover Endogenous and artificial regulators of pituitary glycoprotein hormone receptors, Insight into vitamin D3 action within the ovary - basic and clinical aspects, Hormonal basis of seasonal changes in metabolism, Viral mimicry and endocrine system: Divulging the importance in host-microbiome crosstalk, Recombinant hormones as biopharmaceuticals: past, present and future, Thyroid hormone biosynthesis and its role in brain development and maintenance, and much more.Highlights new advances in the field of hormones and hormone researchCovers topics such as the Estrogen receptor binding mechanism with agonist and antagonist and Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment StudiesServes as an indispensable reference for researchers and students alike

Anandamide in Health and Disease, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, is a complete reference on the roles of anandamide in health and disease states. Following the characteristics of the series, this book provides a comprehensive overview of the effects of the mediator on human health. The book is divided into two parts, the first of which provides background information on biology, regulation, synthesis and degradation and modulation of anandamide. The second part is dedicated to covering the role of anandamide in various diseases. A comprehensive panel of authors cover several somatic and psychiatric disorders, such as anxiety disorders, mood disorders, psychosis and substance use disorders. Additionally, the role of anandamide across epilepsy, Alzheimer's disease, and digestive conditions is explored. Anandamide in Health and Disease is the perfect reference for bioscience researchers seeking to understand anandamide pharmacology, biochemistry, cellular, and molecular biology. Clinicians may also be interested in better understanding the wide-ranging health effects of the mediator.Covers anandamide from a wide variety of specialties and systems.Focuses on the cellular communication aspects of the mediator, and the wide range of effects on human health.Emphasizes the integration of the various roles of anandamide mediated both centrally and peripherally.

Correlative Light and Electron Microscopy V, Volume 187 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Orthotopic brain tumor models derived from glioblastoma stem-like cells, RNA sequencing in hematopoietic stem cells, Generation of inducible pluripotent stem cells from human dermal fibroblasts, In vitro preparation of dental pulp stem cell grafts combined with biocompatible scaffolds for tissue engineering, Gene expression knockdown in chronic myeloid leukemia stem cells, Identification and isolation of slow-cycling GSCs, Assessment of CD133, EpCAM, and much more.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Methods in Cell Biology seriesIncludes the latest information on the topic of development, characterization and applications in CAR T Cells

Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more. Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoid dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more.Provides detailed articles regarding how to study the structures and mechanisms of mononuclear non-heme iron dependent enzymesGuides readers on how to use partner proteins in non-heme iron enzyme catalysisIncludes strategies to employ mononuclear non-heme iron enzymes in biocatalytic applications

Applied Multivariate Statistical Analysis in Medicine provides a multivariate conceptual framework that allows readers to understand the interconnectivity and interrelations among variables, which maintains the intrinsic precision of statistical theories. With a strong focus on the fundamental concepts of multivariate statistical analysis, the book also gives insight into the applications of multivariate distribution in biomedical fields. In 14 chapters, Applied Multivariate Statistical Analysis in Medicine covers the main topics of multivariate analysis methods widely used in health science research. The content is organized progressively from fundamental concepts to sophisticated methods. It begins with basic descriptive statistics in multivariate analysis and follows with parameter estimation, in addition to the hypothesis testing of a multivariate normal distribution, which has heavy applications in biomedical fields where the relationships among approximately normal variables are of great interest. Keeping mathematics to a minimum, considerable emphasis is placed on explanations and real-world applications of core principles to maintain a good balance between introducing theory and cultivating problem-solving skills. This book is a very valuable reference text for clinicians, medical researchers, and other researchers across medical and biomedical disciplines, all of whom confront increasingly complex statistical methods during the analysis and presentation of their results.Gives understanding and mastering of the multivariate analysis techniques in the medical sciencesMaintains a balance between the introduction of statistical analysis theory and the cultivation of practical skillsExposes a variety of well-designed real-life cases that integrate concepts and analytical techniquesIncludes substantive exercises, online coding sources, and case discussions to solidify a conceptual understanding

Primate Anatomy synthesizes the taxonomy, anatomy, physiology, and genomics of extant primates, including humans. It takes a holistic approach to describing primate skeletal, muscular, and organ structure and function. This book provides the tools to understanding the fundamentals and state of the science of primatology. Now in its fourth edition, this work introduces its audience to the history and objectives of the field of primatology. It enumerates and profiles extant primates before delving into detailed descriptions of primate skulls, brains, teeth, skeletons, musculature, organs, blood groups, reproduction, and development. The book highlights recent advances in primate genomics, including new genera and species assignments, and concludes with a glance at the future of the field. Written by longtime expert Friderun Ankel-Simons, the fourth edition of Primate Anatomy effectively introduces complex biological concepts in a manner accessible to all readers. This book serves as an excellent reference for technical and non-technical audiences, including primatologists, anatomists, paleontologists, anthropologists, conservationists, and naturalists.Offers holistic coverage of the anatomy and physiology of extant primatesHighlights taxonomic developments since the publication of the third edition of Primate Anatomy, including new genera and species assignmentsIntroduces primate genomics and gender issues among primatesProvides instructive and comprehensive review tablesIncludes many unique, novel, and easily understandable illustrations

Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in Methods in Enzymology seriesUpdated release includes the latest information on G4 biology

Animal Models of Disease, Part A, Volume 185 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including New mouse model to study aneurysm development, Mouse Model of Secondary Cystic Echinococcosis, Modelling childhood cancer in Drosophila, Analysis of immunohistomorphological changes in the colonic mucosa in a high-saturated fat and high-cholesterol fed streptozotocin/nicotinamide diabetic rat model, Establishment of an orthotopic Glioblastoma mouse model for preclinical studies, Lateral Fluid Percussion Injury as a Model for Traumatic Brain Injury, Ovarian and colorectal peritoneal carcinomatosis in mouse models, and more.Other chapters cover Genetically engineered mouse model of hepatocellular carcinoma, Radiotherapy protocol in cancer mouse models, Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation, Methodology for the induction of myocardial infarction and cardiac function evaluation, Behavioral assessment of fine socio-sexual olfactory cues detection in a mouse model of neurodegeneration, Heat shock and thermotolerance in Caenorhabditis elegans: an overview of laboratory techniques, and Using the model cestode Taenia crassiceps for the study of cysticercosis.Provides the latest information on cancer researchOffers outstanding and original reviews on a range of cancer research topicsServes as an indispensable reference for researchers and students alike

Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.Provides the latest information on cancer researchOffers outstanding and original reviews on a range of cancer research topicsServes as an indispensable reference for researchers and students alike

Cellular Senescence and Aging, Volume 181 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as assessing polyglutamine tract aggregation in the nematode Caenorhabditis elegans, Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino, Methods for detection of mitochondrial reactive oxygen species in senescent cells, Assessment of cell cycle progression and mitotic slippage by videomicroscopy, The original colorimetric method to detect cellular senescence, and more.Additional sections cover Assessing microbiota composition in the context of aging, Assessing chronological aging in Saccharomyces cerevisiae, Image processing and supervised machine learning for retinal microglia characterization in senescence, Measuring telomerase activity using TRAP assays, High throughput assessment of cellular senescence, Detection of radiation-induced senescence by the Debacq-Chainiaux protocol: Improvements and upgrade in the detection of positive events, Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP), Flow cytometry-assisted quantification of cell cycle arrest in cancer cells treated with CDK4/6 inhibitors, and more.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Methods in Cell Biology seriesUpdated release includes the latest information on Cellular Senescence and Aging

This volume provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, life cycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume would aid in grasping complex concepts, serving as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health. Comprehensive coverage of various aspects of the COVID-19 pandemic, including virus structure, variants, immune responses, disease pathogenesis including its multiorgan manifestations and long COVID Focus on in-depth analysis of innate and adaptive immune responses to SARS-CoV-2, including B cell and T cell responses, discussing the recognition and activation mechanisms, antibody production, immunological memory as well as the role of spike proteins in immunological regulation Richly illustrated with informative diagrams, providing visual aids to enhance understanding of complex concepts and structures related to COVID-19

Microbial Diversity in the Genomic Era, Second Edition presents techniques used for microbial taxonomy and phylogeny, along with their applications and respective strengths and challenges. Though many advanced techniques for the identification of unknown bacterium are available in the genomic era, a far fewer number of the total microbial species have been discovered and identified to date. With that in mind, this book incorporates recently developed biosystematics methods and approaches to assess microbial taxonomy, with suitable recommendations for where to apply them across the range of bacterial identification and infectious disease research. Here, international researchers in the field first provide a broad overview of microbial genomics research and microbiome directed medicine, followed by sections on molecular tools for microbial diversity research, extremophilic microbial diversity, functional microbial diversity across application areas, microbial diversity and infectious disease research, and future directions for research. Step-by-step methodologies are provided for key techniques, along with applied case studies breaking down recent research studies into the practical components, illuminating pathways for new studies across the field. This new edition has been fully updated to address advances in the field of microbiome directed medicine, and whole genome sequencing for studying microbial diversity, considering both recent technological advances and new applications areas, from extremophile studies to the latest approaches in human microbiome analysis.Instructs in techniques used for microbial taxonomy and phylogeny, with discussions of their applications and respective pros and consReviews the evolving field of microbial typing and the genomic technologies that enable comparative metagenomic analysis of complex microbial environmentsCovers microbiome directed translational research, as well as whole genome sequencing for studying microbial diversity, with newly added research protocols and case studiesReviews future applications in the field of microbiome directed medicineFeatures chapter contributions from global experts in the field

Advances in Protein Chemistry and Structural Biology, Volume 138 covers reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design. Chapters in this release include Proteomic Applications in Identifying Protein-Protein Interactions, Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach, Proteomics provides insights into theranostic potential of extracellular vesicles, Towards a shareable functional analysis of the structural proteome, Functional unfoldomics, In-silico Network Pharmacology Study on Glycyrrhiza glabra: Analyzing the Immune-Boosting phytochemical properties of Siddha Medicinal Plant against COVID-19, and more.Other chapters cover In silico Network Pharmacology Analysis and Molecular Docking Validation of Swasa Kudori for Screening Druggable Phytoconstituents of Asthma, Proteomics and Genomics Insights on Malignant Osteosarcoma, Application of functional proteomics in understanding RNA Virus-Mediated Infection, Biofilm proteome of Staphylococcus aureus: implications for therapeutic interventions to biofilm-associated infections, A computational pipeline elucidating functions of conserved hypothetical Trypanosoma cruzi proteins based on public proteomic data, Functional Proteomics based on Protein Microarray Technology for Biomedical Research, and an Analysis of endoglucanases production using proteomics and metatranscriptomics.Includes new information about Protein AggregationPresents chapters by a wide range of leading expertsCover new, cutting-edge information that will serve as an essential addition to any bookshelf or laboratory

Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion of synthesizing biological catalysts using asymmetric synthesis, for applications across research and industry. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries, with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products.Explores biocatalysts as exquisite catalysts for fine chiral compound synthesis in different reaction mediaFeatures both foundational overviews and applied, practical examples across research and industryIncludes chapter contributions from international leaders in the field

Advances in Cytometry: Applications, Volume 176 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Orthotopic brain tumor models derived from glioblastoma stem-like cells, RNA sequencing in hematopoietic stem cells, Generation of inducible pluripotent stem cells from human dermal fibroblasts, In vitro preparation of dental pulp stem cell grafts combined with biocompatible scaffolds for tissue engineering, Gene expression knockdown in chronic myeloid leukemia stem cells, Identification and isolation of slow-cycling GSCs, Assessment of CD133, EpCAM, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Includes the latest information on the topic of development, characterization and applications in CAR T Cells

Handbook of Whale Optimization Algorithm: Variants, Hybrids, Improvements, and Applications provides the most in-depth look at an emerging meta-heuristic that has been widely used in both science and industry. Whale Optimization Algorithm has been cited more than 5000 times in Google Scholar, thus solving optimization problems using this algorithm requires addressing a number of challenges including multiple objectives, constraints, binary decision variables, large-scale search space, dynamic objective function, and noisy parameters to name a few. This handbook provides readers with in-depth analysis of this algorithm and existing methods in the literature to cope with such challenges. The authors and editors also propose several improvements, variants and hybrids of this algorithm. Several applications are also covered to demonstrate the applicability of methods in this book. Provides in-depth analysis of equations, mathematical models and mechanisms of the Whale Optimization Algorithm Proposes different variants of the Whale Optimization Algorithm to solve binary, multiobjective, noisy, dynamic and combinatorial optimization problems Demonstrates how to design, develop and test different hybrids of Whale Optimization Algorithm Introduces several application areas of the Whale Optimization Algorithm, focusing on sustainability Includes source code from applications and algorithms that is available online

Concepts and Techniques in OMICS and Systems Biology provides a concise and lucid account on the technical aspects of omics, system biology and their application in fields of different life science. With a strong focus on the fundamental principles understanding of metabolomics, ionomics and system biology, the book also gives an updated account on technical aspects of omics and system biology. Since both omics and systems biology fields are fast advancing filed of biological sciences, its significance and applications need to be understood from the baseline. In 10 chapters Concepts and Techniques in OMICS and Systems Biology introduces the reader to both Proteomics, Metabolomics and Ionomics, and System Biology, the technical applications, describes both the software in for proteomics as metabolomic enumeration and preludes Omics technologies and their applications. The chapters are designed in a well-defined chronology such that readers will understand the concepts and techniques involved in omics and system biology. This compilation will be ideal reading material for students, researchers and people working in the industries related to biological sciences.Provides an in-depth explanation of fundamental principles regarding the understanding of metabolomics, ionomics and system biology.Gives updated account on technical aspects of omics and system biology.Includes unique content in its theoretical background, technical approaches and advancements made in omics and systems biology

Methods in Enzymology Volume 702 highlights new advances in the field, with this new volume presenting interesting topics on Siderophore and related natural products biosynthesisProvides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in Methods in EnzymologyUpdated release includes the latest information on Siderophore and related natural products biosynthesis

Advances in Clinical Chemistry, Volume 119, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. Topics covered in this new release include Advances in Endotoxin Analysis, SARS-CoV-2 detection and surveillance, Osteopontin in Cancer, Gastrointestinal Hormones: History, Biology, and Measurement, Natriuretic Peptide Testing Strategies in Heart Failure: a 2023 Update, and Defining Allowable Total Error Limits in the Clinical Laboratory.Provides the most up-to-date technologies in clinical chemistry and clinical laboratory scienceAuthored by world renowned clinical laboratory scientists, physicians, and research scientistsPresents the international benchmark for novel analytical approaches in the clinical laboratory

A Biologist's Guide to Artificial Intelligence: Building the Foundations of Artificial Intelligence and Machine Learning for Achieving Advancements in Life Sciences provides an overview of the basics of Artificial Intelligence for life science biologists. In 14 chapters/sections, readers will find an introduction to Artificial Intelligence from a biologist's perspective, including coverage of AI in precision medicine, disease detection, and drug development. The book also gives insights into the AI techniques used in biology and the applications of AI in food, and in environmental, evolutionary, agricultural, and bioinformatic sciences. Final chapters cover ethical issues surrounding AI and the impact of AI on the future. This book covers an interdisciplinary area and is therefore is an important subject matter resource and reference for researchers in biology and students pursuing their degrees in all areas of Life Sciences. It is also a useful title for the industry sector and computer scientists who would gain a better understanding of the needs and requirements of biological sciences and thus better tune the algorithms.Helps biologists succeed in understanding the concepts of Artificial Intelligence and machine learningEquips with new data mining strategies an easy interface into the world of Artificial IntelligenceEnables researchers to enhance their own sphere of researching Artificial Intelligence

RNA Therapeutics, Part B, Volume 204 updates on a new class of medication based on RNA molecules, with chapters on a variety of topics, including RNA therapeutics for cardiovascular disorders, RNA therapeutics for kidney injury, RNA therapeutics for beta-thalassemia, RNA therapeutics for infectious diseases, RNA therapeutics for reproductive diseases, Potential of RNA and transcriptomic data to drive drug repurposing for various diseases, RNA therapeutics for glioma/glioblastoma, RNA therapeutics for regenerative medicine, Advances in the liposome-based delivery systems for RNA therapeutics in cancer, Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics in cancer, and more.Covers RNA therapeutics'history and future perspectivesDiscusses the processes of RNA therapeutical developmentPresents recent applications of RNA therapeutic in clinicsProvides the advantages and disadvantages of RNA therapeutics

Cell-based Cancer Immunotherapy, Volume 183 provides the latest progress concerning research on anticancer cellular immunotherapies and their immunological, translation, or clinical aspects. Topics covered in this volume include Methods behind clinical DC vaccine products against glioblastoma, Fully closed and automated isolation of natural blood dendritic cells for cancer immunotherapy, Methods behind Oncolytic virus-based DC vaccines in cancer: towards a multiphase combined treatment strategy for Glioblastoma (GBM) patients, Identification of TCR repertoire patterns linked with anti-cancer immunotherapy, Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells, Methods behind neoantigen predictions for anticancer vaccines, Methods behind CD137L-DC-EBV-VAX anticancer vaccine, and much more. Additional sections cover Gold Standard Assessment of Immunogenic Cell Death Induced by Photodynamic Therapy: From In Vitro to Tumor Mouse Models and Anti-Cancer Vaccination Strategies, Methods behind TCR analyses for colorectal cancer-associated TILs, The use of xCELLigence, Incucyte, and/or Cr/LDH/maker-release assays, Humanized mouse models for anti-cancer therapy, In vitro re-challenge of CAR T cells, Methods behind adoptively transferred tumor draining lymphocytes? for anticancer immunotherapy, and A murine glioblastoma platform to test cellular therapies with the standard of care.Provides comprehensive method articles from front-line experts on the topic of anticancer cellular immunotherapiesProvides useful schematic material and cutting-edge discussionsPresents the latest insights and future perspectives on the covered topics, along with their implications for immuno-oncology, as well as clinical perspectives

The emergence of genomic variability is a fundamental process in evolution that has been the focus of recent high-profile scientific debates, with a particular focus on epigenetic modifications shown to influence genomic variability.Epigenetics and Evolution, a new volume in the Translational Epigenetics series, introduces key themes from current epigenetic evolution research, with contributions from leading scientists around the world that investigate the role of epigenetic mechanisms in evolution from a variety of different angles, with each contribution combining theory, current research overviews, and applications. This book gives researchers, students, and clinicians a better understanding of the origin of genotypic and phenotypic variability, the role of epigenetics in development and inheritance, how epigenetics may affect speciation and geographic distribution, and the evolution of epigenetic mechanisms in different taxa, and helps them apply their learnings across new research. Other modalities and subtopics explored include epigenetics in neutral evolution; epigenetics and cellular physiology; Paleo-epigenetics; Archeo-epigenetics; epigenetics and pathogen evolution; epigenetics in unicellular organisms; epigenetic evolution in plants, invertebrates, and vertebrates; and the role of epigenetics in human evolution and its societal impact.Introduces and examines the role of epigenetic modifications in regulating genomic variability, and thus evolutionary biology, across speciesDraws together key themes across epigenetic evolution in plants, invertebrates, and vertebrates, and the role of epigenetics in human evolutionIncludes bulleted chapter summaries and key points lists, terms and definitions, and rich use of illustrations where possible to reinforce understanding and actionability of the contentFeatures chapter contributions from international leaders in the field

Resilient Health: Leveraging Technology and Social Innovations to Transform Healthcare for COVID-19 Recovery and Beyond presents game-changing and disruptive technological innovations and social applications in health and mental health care around the world for the post-COVID age and beyond, addressing the urgent need for care.In this first-of-its kind comprehensive volume, experts and stakeholders from all sectors - government and the public and private sectors - offer models and frameworks for policy, programming, and financing to transform healthcare, address inequities, close the treatment gap, and “build back better,” especially for under-resourced vulnerable communities globally, to “leave no one behind” and advance development globally. Contributions from world experts cover 8 essential parts: The context and challenges for resilient health systems to shape the future; developments and directions (AI, VR, MR, IVAs and more); an innovations toolbox, also targeted for special populations and settings (women, youth, ageing, migrants, disabled persons, indigenous peoples, in the workplace); the role of stakeholders (governments, the public and private sector); forums and networks; innovative financing; resources, lessons learned and the way forward.Addresses the “hot” topic today in the ever-emerging landscape of disruptive digital healthcare delivery, covering critical issues and solutions in digital health, big data, and artificial intelligence as well as benefits and challenges, and ethical concernsProvides case examples of transformative and radical solutions to urgent health needs, especially in remote low-resource settings as well as in less well-covered regions of Central and South America and MENA (Middle East and North Africa)Positions health innovations at the nexus of the global framework of Universal Health Coverage and of the United Nations Sustainable Developing Goals to achieve SDG3 - good health and well-being –at the intersection with climate action, gender equality, quality education, eradication of poverty and hunger, sustainable cities, environmental protection and others.Serves as an exceptional resource, reference, teaching tool, and guide for all stakeholders including civil society and NGOs, government, think tanks, investors, academia, researchers and practitioners, product developers and all policymakers and programmers involved in planning and delivering healthcare, including an extensive section of resources in the digital health space in various categories like publications, conferences, and collaboratives.Provides examples of, and encourages, multi-stakeholder partnerships essential to re-imagine health systems, delivery and access, and to achieve intended healthcare objectives

Advances in Clinical Chemistry, Volume 123, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists.Provides the most up-to-date technologies in clinical chemistry and clinical laboratory scienceAuthored by world renowned clinical laboratory scientists, physicians, and research scientistsPresents the international benchmark for novel analytical approaches in the clinical laboratory

CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A, Volume 208 represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing, which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and more. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source.This volume offers CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease, fungal disease, stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders. In addition, it highlights a number of aspects of the CRISPR-Cas systems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.Updares on CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease and fungal diseaseDiscusses stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disordersIncludes commentary on CRISPR in autoimmune and blood disorders

COVID-19 Management in the Brain and Body describes the management of patients with the novel coronavirus in their varied symptoms. Detailing this multisystem disease and the variety of organs and tissues affected, this volume features chapters on neurological systems, including brain cancer, brain embolism, and meningoencephalitis. Several systems are addressed, including conditions affecting hematological, hepatobiliary, gastrointestinal, and cardiovascular systems. Telemedicine and are also discussed. This volume is relevant for all clinicians working to ensure the best outcomes and patient care of patients with COVID-19.Discusses the management of multisystem symptomatology, including the effects of COVID-19 on the neurological, respiratory, hematological, hepatobiliary, gastrointestinal, and cardiovascular systemsIncludes select guidelines for clinics providing care for COVID-19 patientsFeatures individual chapter introductions, and a section on case studies to provide a comprehensive primer for each topicContains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures

Linking Neuroscience and Behavior in COVID-19 examines the impact of the virus and pandemic on behavior and mental health. Chapters look at those with pre-existing conditions, including dementia and multiple sclerosis, and how the pandemic has burdened them further. There is also discussion on the mental health consequences the pandemic has had and continues to have on the broad populace, including depression and anxiety, as well as neurological effects of the virus itself. Finally, managing care and treatment of conditions - those preceding, caused by, or emerging for the first time during the pandemic are also detailed.Discusses the impact of the COVID-19 pandemic and the virus itself on behavior and psychologyExamines comorbidities including Parkinson's disease, neuroinflammation, and autism spectrum disordersOutlines the management and care for coexisting conditions including brain tumors, multiple sclerosis, and ischemic strokeFeatures chapters on the severe damage to the nervous system which may be caused by SARS-CoV-2 infection including myelitisContains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures

International and Life Course Aspects of COVID-19 describes the nuances and international variations of COVID-19 in different populations and age groups. This volume details those differences in chapters examining the effects of the virus at different life stages, including newborns, children, adolescents, and older populations. Consideration of the age-specific effects of COVID-19 on the brain are a major focus unique to this resource. International observations and global outcomes are also described. This volume is relevant for all clinicians working to ensure the best outcomes for patients with COVID-19 worldwide.Examines COVID-19 symptoms and concerns according to ageDiscusses outcomes related to global populations and differences observed in symptomatology and careFocuses on the brain, with a look at developmental changes in pregnancy, newborns, childhood, and adolescenceDescribes mental health impacts in the older populationsFeatures individual chapter introductions and summaries to provide a comprehensive introductionContains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures

Features, Transmission, Detection, and Case Studies in COVID-19 examines the effects of the virus on the body, as well as its transmission and clinical profile. This volume begins with an introduction to the virus and its pathogenesis, transmission, and avoidance, followed by sections on pulmonary and cardiovascular effects, obesity, diabetes, the liver, detection issues, and biomarkers. Vaccines and treatment are also discussed. Specific case studies covered include hypoxia, acute kidney injury, pneumonia, and neurological effects. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.Discusses COVID-19 biology, including pathogenesis and transmissionDescribes systemic issues caused by COVID-19, including cardiovascular effects and loss of taste and smellOutlines detection methods, biomarkers associated with severity, and disease outcomesFeatures individual chapter introductions, summaries, and case studies to provide comprehensive descriptions of COVID-19 symptoms and effectsContains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures

Vertebrate Pattern Formation, Volume 159 in the Current Topics in Developmental Biology series, highlights advances in the field, with this volume presenting interesting chapters on timely topics, including Hox genes patterning the vertebrate body, Endodermal patterning, The use of organoids/gastruloids to understand development, Cell shape and movements controlling development, Neural crest and placodes in vertebrate development, Patterning of the neural tube, Non-canonical Wnt signaling in axial extension, The control of transitions along the main body axis, Emergence of a left-right symmetric body plan in vertebrate embryos, Formation of the vascular system, Generation of patterns in the paraxial mesoderm, and more.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Current Topics in Developmental Biology seriesUpdated release includes the latest information on the Vertebrate Pattern Formation

Reverse Vaccinology: Concept, Methods and Advancement presents the development strategy of new vaccines through genome sequencing bioinformatics analysis. Reverse vaccinology promises to revolutionize vaccine development, especially for pathogens to which the classical applications of Pasteur's principles have failed, and it is explained in detail in this book.The book is split into three sections: the first, Concept, brings the basis of reverse vaccinology, vaccine antigen discovery, and subunit vaccine; the second, Tools and Methods, describes immunoinformatic, proteomics for epitope-vaccine design, data bases, network analysis, machine learning, and NGS driven antigen screening technology; and the last one, Disease Case Study, discusses real-world examples in the development of new vaccines for diverse diseases.It is a valuable resource for bioinformaticians, researchers, students, and member of the biomedical and medical fields who want to learn more about a new and agile process for the development of new vaccines.? Explains the fundamentals of reverse vaccinology and how it can save time in the development of new vaccines? Focuses on the efforts to develop a vaccine candidate against various pathogens using computational approaches? Presents databases and web servers for conducting reverse vaccinology? Describes the screening process of potential vaccine candidate through machine learning

Microbial Biostimulants for Plant Growth, Development and Abiotic Stress Amelioration provides readers with insights into the major role of biostimulants in plant growth and development while under abiotic stress. The term biostimulants is broadly used to reference a group of diverse substances and microorganisms that stimulate life or that promote favorable plant responses. They stimulate natural processes to enhance/benefit nutrient uptake, nutrient efficiency, tolerance to abiotic stress, and crop quality. Many biostimulants improve nutrition and they do so regardless of their own nutrient contents. Further, recently microbe-based biostimulants have emerged as important plant protectors under a range of adverse conditions. Microbial Biostimulants for Plant Growth, Development and Abiotic Stress Amelioration is the latest volume in the Biostimulants and Protective Biochemical Agents series. Presents the potential for more environmentally sustainable interventions against abiotic stressesHighlights the variety of applications for which biostimulants are proving effectiveIncludes coverage of commercialization and role in addressing Sustainability Development Goals

Muscle Stem Cells, Volume 158 in the Current Topics of Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics surrounding Muscle stem cell dysfunction in rhabdomyosarcoma and muscular dystrophy, Model systems used to study MuSC function, MuSCs in the growth and maintenance of muscle, Molecular regulation of myocyte fusion, A self-made quiescent niche of muscle stem cells, Characterization of the muscle regenerative environment, Role of microenvironment on muscle stem cell function in health, adaptation, and disease, Vascular Niche for Muscle Stem Cells, Regulation of muscle stem cell polarity in health and disease, and more.Additional chatpers cover Circadian timing of satellite cell function and muscle regeneration, Muscle stem cell activity is regulated by translational control of gene expression, Biomechanical stress in modulating MuSC function, Cross talk between cell types in regenerating muscle, Effects of the immune system on muscle regeneration, Effects of diabetes on MuSC function, and other timely topics.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Current Topics in Developmental Biology seriesUpdated release includes the latest information on the Muscle Stem Cells

Peptide Chemical Tools for Modulating Biology, Volume 698 in the esteemed Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Peptide tools that target telomere maintenance, Molecular Design of Peptide Therapeutics, Sulfonyl peptide tools for modulating biology, Peptide tools for targeting the Crk/CrkL-p130Cas axis, Quorum sensing peptide tools, In vivo stability and BBB penetration of peptide tools, and Oligo-benzamide-based peptide mimicking tools for modulating biology.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in Methods in EnzymologyUpdated release includes the latest information on Peptide Chemical Tools for Modulating Biology

Myeloid-Derived Suppressor Cells, Volume 184 in the Methods in Cell Biology series includes comprehensive protocols to assess the role of myeloid-derived suppressor cells (MDSCs), an immature, heterogenous cell population from the myeloid lineage with a potent immunosuppressive activity in a variety of diseases. This volume includes interesting protocols that address the Detection of myeloid-derived suppressor cells by flow cytometry, Determination of murine myeloid-derived suppressor cells by flow cytometry, Isolation of Myeloid-Derived Suppressor Cells (MDSC) from Endometriotic Mice Model and their Immunomodulatory Functions, Simple protocol for measuring CD11b+ GR-1+ (Ly6C+/Ly6G+) myeloid cells from a minimum volume of mouse peripheral blood, and much more.Additional chapters cover Assessment of myeloid-derived suppressor cell differentiation ex vivo, Single clonal tracking on biomimetic microtextured platforms for real-time guided migration analysis of myeloid-derived suppressor cell dissemination characteristics ex vivo, Isolation and immunosuppressive functions of myeloid-derived suppressor cell-derived exosomes, Characterization of lysosomal acid lipase in Ly6G+ and CD11c+ myeloid-derived suppressor cells, In Vitro Osteoclastogenesis Assessment using Murine Myeloid-derived Suppressor Cells, Estimating Nitric Oxide (NO) from MDSCs by Griess Method, and In vitro generation of myeloid-derived suppressor cells (MDSCs) from hematopoietic progenitor cells (HPCs).Provides the authority and expertise of leading researchers in myeloid-derived suppressor cellsIncludes comprehensive and detailed protocols to assess the detrimental role of myeloid-derived suppressor cellsPresents the latest release in the Methods in Cell Biology series

RNA Therapeutics, Part A, Volume 203 presents the latest on a new class of medication based on RNA molecules. The book includes timely chapters that focus on An introduction to RNA therapeutics and potentials, The development and technologies of RNA therapeutics, Types of RNA therapeutics, Molecular mechanisms of RNA therapeutics, IT, and AI applications in RNA therapeutics, The application of data sciences and bioinformatics in RNA therapeutics, RNA therapeutics history and future perspectives, Recent applications of RNA therapeutic in clinics, Advantages and disadvantages of RNA therapeutics, RNA therapeutics for neurological disease, RNA therapeutics for metabolic disorders, and RNA therapeutics for metabolic disorders.Discusses the history of RNA therapeutics, along with future perspectivesPresents the processes of RNA therapeutical developmentsCovers recent applications of RNA therapeutics in clinicsProvides the advantages and disadvantages of RNA therapeutics

Transglutaminase: Fundamentals and Applications, a new volume in the Foundations and Frontiers in Enzymology series, stands as a comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field from the Editors, international experts discuss basic biology and structure – function relationships of transglutaminases, ongoing fundamental research, as well as new application areas, including food processing, material synthesis, biomedicine and disease treatment, and biotechnology. Approaches for sourcing transglutaminases from animals, plants, and microorganisms are considered in-depth, followed by chapters on applied uses in biomedicine, skin and bone biology and medicine, drug development, tissue engineering, seafood bioprocessing, dairy bioprocessing, synthesis of materials and polymers, and as an immobilization agent. Research protocols are also provided, including research rationale, design, substrates, assays and microassay steps for studying transglutaminases.Brings together basic knowledge and applied research on transglutaminase biologyConsiders a range of application areas, from biomedicine to drug development, tissue engineering, food processing, and materials synthesisIncludes instructive protocols for basic and applied transglutaminase researchFeatures chapter contributions from global leading experts in the field, across disciplines and applications

International Review of Cell and Molecular Biology, Volume 381 highlights new advances in the field, with this new volume presenting interesting topic on Overview of Inflammatory Breast Cancer: Updates.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in International Review of Cell and Molecular BiologyUpdated release includes the latest information on Overview of Inflammatory Breast Cancer and Updates

Rigor and Reproducibility in Genetics and Genomics: Peer-reviewed, Published, Cited provides a full methodological and statistical overview for researchers, clinicians, students, and post-doctoral fellows conducting genetic and genomic research. Here, active geneticists, clinicians, and bioinformaticists offer practical solutions for a variety of challenges associated with several modern approaches in genetics and genomics, including genotyping, gene expression analysis, epigenetic analysis, GWAS, EWAS, genomic sequencing, and gene editing. Emphasis is placed on rigor and reproducibility throughout, with each section containing laboratory case-studies and classroom activities covering step-by-step protocols, best practices, and common pitfalls. Specific genetic and genomic technologies discussed include microarray analysis, DNA-seq, RNA-seq, Chip-Seq, methyl-seq, CRISPR gene editing, and CRISPR-based genetic analysis. Training exercises, supporting data, and in-depth discussions of rigor, reproducibility, and ethics in research together deliver a solid foundation in research standards for the next generation of genetic and genomic scientists.Provides practical approaches and step-by-step protocols to strengthen genetic and genomic research conducted in the laboratory or classroomPresents illustrative case studies and training exercises, discussing common pitfalls and solutions for genotyping, gene expression analysis, epigenetic analysis, GWAS, genomic sequencing, and gene editing, among other genetic and genomic approachesExamines best practices for microarray analysis, DNA-seq, RNA-seq, gene expression validation, Chip-Seq, methyl-seq, CRISPR gene editing, and CRISPR-based genetic analysisWritten to provide trainees and educators with highly applicable tools and strategies to learn or refine a method toward identifying meaningful results with high confidence in their reproducibility

Clinical Application of Repurposed Drugs, Volume 207 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on Drug repurposing for viral disease, Drug repurposing for bacterial infections, Drug repurposing for parasitic protozoan diseases, Drug repurposing for fungal infections, Drug repurposing for treating anxiety and depression, Drug repurposing for personalized medicine, Drug repurposing for cancer, Drug Repurposing: A multi targeted approach to treat cardiac disease from existing classical drugs to modern drug discovery, and much more. Additional chapters cover Drug repurposing in MASLD and MASH-cirrhosis: targets and treatment approaches based on pathways analysis, Drug repurposing for respiratory infections, Drug repurposing for rare disease, Drug repurposing for neurological disorders, Drug repurposing for metabolic disorders: scientific, technological and economic issues, Drug repurposing for regenerative medicine and cosmetics: scientific, technological and economic issues, and Exploring Cutting-Edge Omics-Driven Strategies for Drug Repurposing – An Insight into the Tools of the Trade.Provides the authority and expertise of leading contributors from an international board of authorsPresents the latest release in the Progress in Molecular Biology and Translational Science seriesIncludes the latest information on Clinical Applications of Repurposed Drugs