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The revolution in science that is transforming our understanding of extinct lifeWe used to think of fossils as being composed of nothing but rock and minerals, all molecular traces of life having vanished long ago. We were wrong. Remnants of Ancient Life reveals how the new science of ancient biomolecules—pigments, proteins, and DNA that once functioned in living organisms tens of millions of years ago—is opening a new window onto the evolution of life on Earth.Paleobiologists are now uncovering these ancient remnants in the fossil record with increasing frequency, shedding vital new light on long-extinct creatures and the lost world they inhabited. Dale Greenwalt is your guide to these astonishing breakthroughs. He explains how ancient biomolecules hold the secrets to how mammoths dealt with the bitter cold, what colors dinosaurs exhibited in mating displays, how ancient viruses evolved to become more dangerous, and much more. Each chapter discusses different types of biomolecules and the insights they provide about the physiology, behavior, and evolution of extinct organisms, many of which existed long before the age of dinosaurs.A marvelous adventure of discovery, Remnants of Ancient Life offers an unparalleled look at an emerging science that is transforming our picture of the remote past. You will never think of fossils in the same way again.

“The most remarkable history of biology that has ever been written.”—Michel FoucaultNobel Prize–winning scientist François Jacob's The Logic of Life is a landmark book in the history of biology and science. Focusing on heredity, which Jacob considers the fundamental feature of living things, he shows how, since the sixteenth century, the scientific understanding of inherited traits has moved not in a linear, progressive way, from error to truth, but instead through a series of frameworks. He reveals how these successive interpretive approaches—focusing on visible structures, internal structures (especially cells), evolution, genes, and DNA and other molecules—each have their own power but also limitations. Fundamentally challenging how the history of biology is told, much as Thomas Kuhn's Structure of Scientific Revolutions did for the history of science as a whole, The Logic of Life has greatly influenced the way scientists and historians view the past, present, and future of biology.

A fresh look at electricity and its powerful role in life on EarthWhen we think of electricity, we likely imagine the energy humming inside our home appliances or lighting up our electronic devices—or perhaps we envision the lightning-streaked clouds of a stormy sky. But electricity is more than an external source of power, heat, or illumination. Life at its essence is nothing if not electrical.The story of how we came to understand electricity's essential role in all life is rooted in our observations of its influences on the body—influences governed by the body's central nervous system. Spark explains the science of electricity from this fresh, biological perspective. Through vivid tales of scientists and individuals—from Benjamin Franklin to Elon Musk—Timothy Jorgensen shows how our views of electricity and the nervous system evolved in tandem, and how progress in one area enabled advancements in the other. He explains how these developments have allowed us to understand—and replicate—the ways electricity enables the body's essential functions of sight, hearing, touch, and movement itself.Throughout, Jorgensen examines our fascination with electricity and how it can help or harm us. He explores a broad range of topics and events, including the Nobel Prize–winning discoveries of the electron and neuron, the history of experimentation involving electricity's effects on the body, and recent breakthroughs in the use of electricity to treat disease.Filled with gripping adventures in scientific exploration, Spark offers an indispensable look at electricity, how it works, and how it animates our lives from within and without.

A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

How genes are not the only basis of heredity—and what this means for evolution, human life, and diseaseFor much of the twentieth century it was assumed that genes alone mediate the transmission of biological information across generations and provide the raw material for natural selection. In Extended Heredity, leading evolutionary biologists Russell Bonduriansky and Troy Day challenge this premise. Drawing on the latest research, they demonstrate that what happens during our lifetimes--and even our grandparents'and great-grandparents'lifetimes—can influence the features of our descendants. On the basis of these discoveries, Bonduriansky and Day develop an extended concept of heredity that upends ideas about how traits can and cannot be transmitted across generations. By examining the history of the gene-centered view in modern biology and reassessing fundamental tenets of evolutionary theory, Bonduriansky and Day show that nongenetic inheritance—involving epigenetic, environmental, behavioral, and cultural factors—could play an important role in evolution. The discovery of nongenetic inheritance therefore has major implications for key questions in evolutionary biology, as well as human health.Extended Heredity reappraises long-held ideas and opens the door to a new understanding of inheritance and evolution.

Molecular Machines presents a dynamic new approach to the physics of enzymes and DNA from the perspective of materials science. Unified around the concept of molecular deformability—how proteins and DNA stretch, fold, and change shape—this book describes the complex molecules of life from the innovative perspective of materials properties and dynamics, in contrast to structural or purely chemical approaches. It covers a wealth of topics, including nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle of enzymes; supra-molecular constructions with internal stress; nano-rheology and viscoelasticity; and chemical kinetics, Brownian motion, and barrier crossing. Essential reading for researchers in materials science, engineering, and nanotechnology, the book also describes the landmark experiments that have established the materials properties and energy landscape of large biological molecules.Molecular Machines is also ideal for the classroom. It gives graduate students a working knowledge of model building in statistical mechanics, making it an essential resource for tomorrow's experimentalists in this cutting-edge field. In addition, mathematical methods are introduced in the bio-molecular context—for example, DNA conformational transitions are used to illustrate the transfer matrix formalism. The result is a generalized approach to mathematical problem solving that enables students to apply their findings more broadly.Molecular Machines represents the next leap forward in nanoscience, as researchers strive to harness proteins, enzymes, and DNA as veritable machines in medicine, technology, and beyond.

The fascinating science and history of radiationMore than ever before, radiation is a part of our modern daily lives. We own radiation-emitting phones, regularly get diagnostic x-rays, such as mammograms, and submit to full-body security scans at airports. We worry and debate about the proliferation of nuclear weapons and the safety of nuclear power plants. But how much do we really know about radiation? And what are its actual dangers? An accessible blend of narrative history and science, Strange Glow describes mankind's extraordinary, thorny relationship with radiation, including the hard-won lessons of how radiation helps and harms our health. Timothy Jorgensen explores how our knowledge of and experiences with radiation in the last century can lead us to smarter personal decisions about radiation exposures today.Jorgensen introduces key figures in the story of radiation—from Wilhelm Roentgen, the discoverer of x-rays, and pioneering radioactivity researchers Marie and Pierre Curie, to Thomas Edison and the victims of the recent Fukushima Daiichi nuclear power plant accident. Tracing the most important events in the evolution of radiation, Jorgensen explains exactly what radiation is, how it produces certain health consequences, and how we can protect ourselves from harm. He also considers a range of practical scenarios such as the risks of radon in our basements, radiation levels in the fish we eat, questions about cell-phone use, and radiation's link to cancer. Jorgensen empowers us to make informed choices while offering a clearer understanding of broader societal issues.Investigating radiation's benefits and risks, Strange Glow takes a remarkable look at how, for better or worse, radiation has transformed our society.

This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources.Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems.Provides a user-friendly introduction to essential concepts, tools, and applicationsCovers the most commonly used modeling methodsAddresses the modular design problem for biomolecular systemsUses design examples from both natural systems and synthetic circuitsSolutions manual (available only to professors at press.princeton.edu)An online illustration package is available to professors at press.princeton.edu