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The book is interwoven according to the intrinsic logics of modern most important applications of electrospun nanofibers. It discusses such application-oriented nanofibers as self-healing vascular nanotextured materials, biopolymer nanofibers, soft robots and actuators based on nanofibers, biopolymer nanofiber-based triboelectric nanogenerators, metallized nanofibers, and heaters and sensors based on them. It also includes such topics as the injectable nanofibrous biomaterials, fibrous hemostatic agents and their interaction with blood, as well as electrospun nanofibers for face-mask applications. The book also details polyelectrolytes-based complex nanofibers and their use as actuators. It also covers drug release facilitated by polyelectrolytes-based complex nanofibers. The fundamental aspects of electrospinning of polymer nanofibers discussed in the final part of the book link them to the applications described in the preceding chapters. Such topics as polymer solution preparation and their rheological properties, e.g., viscoelasticity and the related spinnability, the electrical conductivity of polymer solutions, and the cascade of the physical phenomena resulting in formation of nanofibers encompass the experimental aspects. Also, the general quasi-1D equations used for modeling of formation of electrospun polymer nanofibers, and the numerical aspects of their solution are discussed in detail, including such modeling-driven applications as nanofiber alignment by electric focusing fields.

This book presents cutting-edge research and developments in the broad field of medical, biological engineering and computing. It gathers the second volume of the joint proceedings of the Mediterranean Conference on Medical and Biological Engineering and Computing (MEDICON) and the International Conference on Medical and Biological Engineering (CMBEBIH), which were held together on September 14-16, 2023, in Sarajevo, Bosnia and Herzegovina. Contributions report on innovative research and practices in molecular biology, tissue engineering and biotechnologies, covering not only medical but also industrial applications. Further, they describe advances in health technologies and medical devices, telemedicine, and robotic applications in clinical medicine and rehabilitation.

Sustainable development has been gaining momentum in the modern world, and the use of nanomaterials in various applications is expanding. This volume explores the increasing valuable use of green nanomaterials in energy production and storage, in biomedical applications, and for agricultural and environmental sustainability. Providing an overview of the synthesis, characterization, and applications of green and sustainable nanomaterials, the volume presents a varied selection of examples in practice. Key features include: Provides valuable information on standard protocols for the synthesis of green nanomaterials Promotes advanced technologies for applications of green and sustainable nanomaterials Demonstrates numerous characterization tools for working with sustainable nanomaterials Explores application areas of the synthesized nanomaterials.

In diesem Buch wird beschrieben, wie Nanomaterialien organischer und mineralischer Natur entworfen und synthetisiert werden können. Das Buch behandelt auch die Visualisierung der entwickelten Nanomaterialien und ihre Bioanwendungen und beschreibt die biomedizinischen Wirkungen und Umweltauswirkungen von Nanomaterialien.Es ist ein ideales Buch für Studenten der Biomedizin oder der Biowissenschaften sowie für Forscher und Fachleute in den Bereichen Medizin, Umweltschutz, Biotechnologie, Landwirtschaft und Lebensmittelindustrie. Dieses Buch befasst sich insbesondere mit den wichtigen Nanomaterialien und Nanobiotechnologien, die in diesen Bereichen der Biomedizin und der Biowissenschaften eingesetzt werden.

This book accumulates the most recent advancements in the field of bioengineering regarding hybrid science named nanobiotechnology and enriches the readers with vast and comprehensive knowledge about different biomedical applications of nanomaterials. It includes drug and gene delivery, tissue engineering, antimicrobial properties, hyperthermia, cancer therapy, bioimaging, biosensing, photoablation therapy, etc., utilizing the potential of different nanomaterials that are helpful for the well-being of diseased individuals. Furthermore, the concerns about multidrug-resistant microorganisms are increasing daily in the healthcare system. Since conventional therapies fail to combat various infectious diseases, novel nanotechnology techniques provide an alternative approach to developing innovative biomaterials. The novel features of nanomaterials need to be exploited for use in the biomedical engineering domain. They should be fabricated so that the novel multifunctional nanomaterials notonly improve drug efficacy but also reduce their side effects. Moreover, a detailed understanding of the nanotoxicological effects of promising biomedical nanomaterials should necessarily be explored using the cell culture approach. Corona of nanomaterials should be investigated in detail to determine its fate in the biological system regarding safety concerns. This is the most important feature that is novel and explored in this book and would be very helpful for customers like clinicians, scientists, engineers, and technicians who will gain extensive knowledge from this book and work together to get the desired results in the healthcare sector.

This book covers a number of engineered nanotheranostics platforms and nanomedicines applications of FDA-approved medicines for early-stage diagnosis and treatment of cancer. The book focuses on (i) the basic design and bioengineering of safe medicines, (ii) physicochemical understanding of surface engineered medicines and their characteristics, (iii) various examples for site-specific bioimaging and multimode therapies, (iv) stimuli-responsive approaches for targeted drug delivery applications, (v) targeted therapeutics approaches for cancer cells or solid tumor ablations, (vi) targeted mechanisms of administrative biomedicines, (vii) impact of surface modification or engineering of biomedicines for site-selective tumor binding ability, and (vii) requirements for clinical trials and FDA approval. The content of this book appeal to readers who are interested in recent developments of FDA-approved cost-effective rapid cancer imaging and therapeutic platforms.

This book reports on the latest research and developments in Biomedical Engineering, with a special emphasis on topics of interest and findings achieved in Latin America. This first volume of a 4-volume set covers advances in biomedical image and signal processing, biomedical optics, and wearable and assistive medical devices. Throughout the book, a special emphasis is given to low-cost technologies and to their development for and applications in clinical settings. Based on the IX Latin American Conference on Biomedical Engineering (CLAIB 2022) and the XXVIII Brazilian Congress on Biomedical Engineering (CBEB 2022), held jointly, and virtually on October 24-28, 2022, from Florianópolis, Brazil, this book provides researchers and professionals in the biomedical engineering field with extensive information on new technologies and current challenges for their clinical applications..

This book describes how methodologies in biochemistry, molecular and cellular biology, electromagnetic bioeffects, and nanotechnology were brought together to construct a nanostructure that is a composite of nucleic acid, carbon nanotube, paramagnetic metallic nanoparticles, and aromatic polymer that is responsive to nonionizing electromagnetic radiation, RFR to microwaves. It demonstrates that the construct can act as a redox catalyst accelerated by nonionizing electromagnetic radiation, and also as a conveyor of genetic modification of specifically targeted eukaryotic and prokaryotic cells. The scientific knowledge necessary to accomplish this is described and step-by-step progress supported by data and examples are noted. The general purpose is to show how such interdisciplinary approaches can lead to disruptive technologies. This book is most valuable to those (molecular biologists, vaccinologists, biomedical engineers, microbiologists) looking for more externally controllable gene vectors, antimicrobials, and antiparasitics, using a totally new nanoparticle platform. Those pursuing biological applications of nanotechnology will also be interested. This text has uniquely multidisciplinary approaches, drawing together chemistry, physics, molecular biology, biochemistry, and biomedical and electrical engineering.

Heavy metals, in general trace elements, are one of the major environmental problems. Nowadays, increasing environmental and global public health concerns related with environmental contamination by heavy metals are well known. Moreover, human exposure has risen dramatically because of an exponential increase of their use in several activities such as agricultural, industrial, technological and urban applications. They are presented in soils, water and atmosphere and they are a serious risk for the food chain.Approximately 10 million contaminated sites have been reported globally, occupying approximately 49.42 million acres of land, of which >50% is contaminated with toxic heavy metals. This situation warrants immediate attention to limit the introduction of heavy metals into soil systems and to remove the prevailing heavy metals from polluted soils. However, the majorities of existing heavy-metal-removal technologies are expensive, inefficient, or generate secondary pollutants. Therefore, it is of great importance to develop cheaper, environmentally friendly and sustainable approaches (including the development of new immobilizing agents) to manage and rehabilitate heavy-metal-contaminated soils. In the light of the aforementioned facts, this book sheds light on this global environmental issue, and proposes solutions to contamination through multi-disciplinary approaches and case studies from different parts of the world. It addresses sustainable heavy metal contamination remediation strategies using the potential applications of recent biological technology such as biotechnology, bioremediation, phytoremediation, biochar, absorbent, genetic engineering, and nanotechnology approaches. This book is of interest to researchers, teachers, environmental scientists, environmental engineers, environmentalists, and policy makers. Also, the book serves as additional reading material for undergraduate and graduate students of environmental microbiology, biotechnology, eco-toxicology, environmental remediation, waste management, and environmental sciences as well as the general audience.

This book provides an overview of various drug delivery systems at the cellular level including biological, chemical methods, and most importantly physical methods such as photoporation, electroporation, mechanoporation, and device-based techniques (e.g., microfluidics), as well as organism-level techniques including nanomaterials, biomaterials, and transdermal. Drug delivery (DD) can be defined as the method and route by which an active pharmaceutical ingredient (API) is administered to promote its desired pharmacological effect and/or convenience and/or to reduce adverse effects. Drug delivery systems are developed to maximize drug efficacy and minimize side effects. As drug delivery technologies improve, the drug becomes safer and more comfortable for patients to use. During the last seven decades, extraordinary progress has been made in drug delivery technologies, such as systems for long-term delivery for months and years, localized delivery, and targeted delivery. The advances, however, will face the next phase considering the future technologies that we need to overcome many physicochemical barriers for new formulation development and biological unknowns for treating various diseases. Thus, various technologies are built at a single-cell level as well as an organism level. This book is useful at the university level for graduate courses or research studies and biotechnology-based companies with research and development on cell-based analysis, diagnosis, or drug screening. This book is also very useful for researchers in drug delivery technologies, which came in frontier research for the past decade.

This book reports on advances in fundamental and applied research at the interface between nanotechnology and biomedical engineering. Gathering peer-reviewed contributions to the 6th International Conference on Nanotechnologies and Biomedical Engineering, ICNBME held on September 20-23, 2023, in Chisinau, Republic of Moldova, this second volume of the proceedings focuses on clinical engineering and instrumentation, bioinformatics, image and signal processing techniques, and new technologies for medical diagnosis, treatment and personalised medicine. With a good balance of theory and practice, the book offers a timely snapshot of multidisciplinary research at the interface between physics, chemistry, biomedicine, materials science, and engineering.

The book presents chitosan and chitosan-based nanocomposites and their extensive applications in medical science. Utilization of chitosan nanostructured composites in different biomedical applications is highlighted. The book is suitable to be used as reference/textbook for studying the biological aspects of chitosan hybrid materials and their efficacy in different therapeutic applications. The important features of the book are summarized as follows:Chitosan as an overviewKey biological aspects of chitosan-based nanocompositesSynthetic techniques for fabrication of chitosan nanocomposites for biomedical applicationsDesigning of chitosan-based smart materials for release of therapeuticsFabrication of nanostructured chitosan-based devices for diagnosis and sensing applicationsChitosan nanocomposites for regenerative applicationsMedicinal and therapeutic efficacy of chitosan-based hybrid materials. ​

The book introduces the research significance of biomedical instrumentation and discusses micro-fabrication techniques utilized for biomedical devices. This book primarily focuses on the reader enlightenment on MEMS medical devices by introducing all the diagnostic devices and treatment tools at one place. The book covers in-depth technical works and general introductions to the devices such that the book can reach technical as well as non-technical readers.

This book highlights theoretical and experimental facts about selective nano-metal oxides. TiO2,ZnO and transition metal oxides which are known to be semiconductors and find applications in various fields. This book presents about recent findings like photo catalysis, sensing,coating and biomedical applications. Therapeutic and future applications that are recently been reported of various metal oxides are presented in this book.

Nanotechnology is essential in the development of advanced technologies for medicine and healthcare. Advances depend on the ability to study these materials and nano-biotechnologies using advanced analytical techniques. Providing a comprehensive overview of analytical techniques for applications in biomedical nanotechnology at both the fundamental and applied level, this book provides a broad perspective of the development of analytical methods involved in materials science and electronics. It highlights the fundamentals and systematic developments of techniques to achieve better characterisation, rapid diagnostics, cost-effective and user-friendly approaches, and state-of-art methodologies for personalised health management, and explains how this fundamental knowledge can be translated into applications in nano-enabled biomedical research. The multidisciplinary readership includes chemists, biologists, physicists, materials scientists, engineers and information technologists. Key Features Provides a comprehensive overview of analytical techniques for applications in biomedical nanotechnology at both the fundamental and applied level Explains how fundamental knowledge of the techniques can be translated to applications in nano-enabled biomedical research Covers state-of-art analytical techniques for biomedical nanotechnology Includes the prospects and challenges with each technique, including potential solutions Provides a multidisciplinary view of interest to chemists, biologists, physicists, materials scientists, engineers and information technologists

This book covers key topics in the emerging field of plasmonic MEMS, with an emphasis on practical aspects. Although readers can find many comprehensive textbooks on electromagnetic waves, nanophotonics and plasmonics, most of these lack the focus needed for a thorough grasp of plasmonic micromachining and MEMS.This book introduces the main framework of plasmonic MEMS, providing an overview of introductory concepts, a thorough description of the basic foundations, along with the state-of-the-art and existing challenges. The author presents an abbreviated overview of the basic physics and devices related to electromagnetic waves and surface plasmons. Additional coverage includes recent advances in the fabrication of sub-100-nm patterns on micro scale devices and structures and a review of emerging techniques in the fabrication of plasmonic systems. A comprehensive and historical review of the current advances in the area of plasmonic nanofabrication is also included.This book focuses on an appealing and distinctive aspect of plasmonics, as a tool for patterning and the fabrication of ultra-fine resolution structures. The author reviews the recent developments in plasmonic MEMS and microsystems for biosensing applications, including refractive-index based label-free biosensing, plasmonic integrated lab-on-chip systems, plasmonic for near-field scanning optical microscopy (NSOM) and plasmonics on-chip system for cellular imaging.

This book highlights the contemporary state of research in multidisciplinary areas of Computer Science, Computer Engineering, Data Science, Electrical and Electronics Engineering, Chemical Engineering, Mechanical Engineering, Physics, Biomedical Sciences, Life Sciences, Medicine, Healthcare, and Business Technology. The accepted submissions to the 9th IRC Conference on Science, Engineering and Technology (IRC-SET 2023) presented on 19 August 2023 are published in this conference proceedings. The papers presented here were shortlisted after extensive rounds of rigorous reviews by a panel of esteemed individuals who are pioneers and experts in their respective domains.

This book highlights recent advances focusing on the synthesis methods of engineered biomaterials and their applications. The book discusses recent applications of various approaches and technology in improving the functional properties and biological activities of biopolymers. It includes two major sections: the first section introduces a range of methods which lead to materials with enhanced properties for a range of practical applications, along with the positives and limitations of the techniques. The second section covers recent trends and advances in application of engineered biomaterials that assist materials scientists and researchers in mapping out the future of these new improved materials through value addition in order to enhance their use. Contributions in the book are done by prominent researchers from industry, academia, and government/private research laboratories across the globe. The book summarizes in a fairly comprehensive manner many of the recent technical advancements in the area of biopolymers. The book is intended to serve as a reference resource in the area of polymers science.

This contributed volume covers all fundamental principles for researchers and professionals interested in the field of Biomaterials and Tissue Engineering, an interdisciplinary field of research with contributions from biomedical scientists, engineers, and physicians. With a strong focus on biomaterials and scaffolds, the book also covers testing and evaluation pathways for in vitro and in vivo studies. This book also presents a broad range of topics including fundamentals of 3D printing and bioprinting, followed by contemporary technology used in tissue engineering applications as well as currently available biomaterials suitable for tissue repair and regeneration. This volume provides information on: (i) why humans need biomaterials, especially in medical applications, (ii) different types of tissue engineering strategies, and (iii) modeling, characterization, and evaluation of outputs of those strategies. This book is a reference material in the field of tissueengineering, and it is very useful for bachelor, M.Sc., and Ph.D. students, researchers, academics, medical, industry, and healthcare professionals from diverse backgrounds.

This book highlights the morphology-property relationship of regenerated cellulose materials and composites, as morphology of materials is the key feature and corresponds to associated applications of/to the materials. It is highly essential to assimilate the literature on morphology-property relationship of cellulose materials. Being the most abundant natural polymer on earth and gateway to large number of applications, cellulose is expected to be researched for higher efficiencies. Various books and research articles have targeted the specific morphologies, the respective characteristics and application areas. This book presents literature on morphology-property relationship of cellulose materials and provides a direction to this relationship. ​

This book addresses challenges for the development of a point-of-care-test platform. The book describes printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection in real samples. The main challenges of point-of-care testing require implementing complex analytical methods into low-cost technologies. This is particularly true for countries with less developed healthcare infrastructure. Washing-free, Lab-on-Chip, and Lab-on-PCB techniques are very simple and innovative for point-of-care device development. The redox cycling technology detects several interesting targets at the same time on a printed chip. The proposed areas are inherently cross-disciplinary, combining expertise in biosensing, electrochemistry, electronics and electrical engineering, health care, and manufacturing. This book focuses on recent advances and different research issues in the nanobiotechnology-enabled biosensor technology and also seeks out theoretical, methodological, well-established, and validated empirical work dealing with these different topics.

This book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs.Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes.This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.

This handbook volume is part of the Reference Series: Micro/Nano Technologies. This individual volume provides a comprehensive, self-contained, and authoritative knowledge in nanomedicine. It covers the theoretical and practical aspects of functionalizations of nanoparticles as nanomedicine, including surface activation, characterization, and microemulsion systems. As a Springer Major Reference Work it is continuously updated online, allowing newcomers and other readers to keep in touch with the most up-to-date information.The book is particularly recommended to undergraduates, postgraduates, researchers, scientists, and field experts. It will inspire innovations in the highly interdisciplinary field of nanomedicine.

This book highlights contemporary state of research in multi-disciplinary areas in Physics, Biomedical Sciences, Chemical Engineering, Mechanical Engineering, Computer Science/Engineering, Life Sciences, and Healthcare. The accepted submissions to the 8th IRC Conference on Science, Engineering and Technology (IRC-SET 2022) that were presented on 6th August 2022, are published in this conference proceedings. The papers presented here were shortlisted after extensive rounds of rigorous reviews by a panel of esteemed individuals who are pioneers and experts in their respective domains.

This book highlights the principles, design and characterization of mechanically compliant soft and foldable robots. Traditional rigid robots with bulky footprints and complicated components prolong the design iteration and optimization for keyhole and minimally invasive transluminal applications. Therefore, there is an interest in developing soft and foldable robots with remote actuation, multimodal sensing and machine intelligence. This book discusses the use of foldable and cuttable structures to design biomimetic deployable soft robots, that can exhibit a fair number of motions with consistency and repeatability. It presents the overall design principles, methodology, instrumentation, metamorphic sensing, multi-modal perception, and machine intelligence for creating untethered foldable active structures. These robotic structures can generate a variety of motions such as wave induction, compression, inchworm, peristalsis, flipping, tumbling, walking, swimming, flexion/extension etc.Remote actuation can control motions along regular and irregular surfaces from proximal sides. For self-deployable medical robots, motion diversity and shape reconfiguration are crucial factors. Deployable robots, with the use of malleable and resilient smart actuators, hold this crucial advantage over their conventional rigid robot counterparts. Such flexible structures capable of being compressed and expanded with intelligence perceptions hold enormous potential in biomedical applications.

This book chronicles the role of advanced nanomaterials and surface engineering technologies in the development of point-of-care biosensors for health and environmental monitoring. All aspects of nanomaterial synthesis and characterization, functionalization methods, sensing surface engineering, signal amplification strategies, use of innovative technologies to enhance sensor efficiency and performances, and innovative applications of nanobiosensors to tackle real-life problems are discussed in this book with a focus on optical and electrochemical based sensing. It also covers the detection of infectious diseases and various disease biomarkers, smartphone-based biosensing, and portable diagnostics module developments with a discussion on the working mechanisms of these devices in various domains. The book also illustrates the recent trends in biosensing, and an overview of the challenges and probable solutions for the translation of biosensors from laboratory prototypes to commercial success. ​

This book presents select proceedings of the North East Research Conclave (NERC 2022). The book mainly covers research related to healthcare and related technologies. It includes broad bioengineering applications divided into four parts, namely, biomaterials and tissue engineering, biomedical science and engineering, drug delivery and therapeutics and cell and molecular biology. The book encompasses the latest research and advancements in the field of healthcare and related technologies. This book also describes a few studies based on computer simulations in bioengineering. In addition, the fundamental and basic aspects are also discussed for the better understanding of readers. The book can be a valuable reference for beginners, researchers and professionals interested in the field of healthcare and related technologies.

This book provides a comprehensive insight into the current research trends and ongoing advances in biomedical applications of magnetic nanoparticles. New uses for magnetic nanoparticles in biomedical fields such as magnetic particle imaging, microfluidics applications, organelle isolation, nanovaccines, and magnetogenetics are presented in keeping with traditional applications of magnetic nanoparticles in clinical diagnostics and therapeutics. Each section of the book provides feature questions with answers available from various research showcases and literature references, together with numerous illustrations to help readers grasp key ideas. The book was written for graduate students and researchers in the fields of magnetic nanomedicine and nanobiotechnology.

Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine'Nanorobotics and nanodiagnostics” can be defined as a new generation of biohybrid and nanorobotics that translate fundamental biological principles into engineering design rules, or integrative living components into synthetic structures to create biorobots and nanodiagnotics that perform like natural systems. Nanorobots or nanobots are structured of a nanoscale made of individual assemblies. They can be termed as intelligent systems manufactured with self-assembly strategies by chemical, physical and biological approaches. The nanorobot can determine the structure and enhance the adaptability to the environment in interdisciplinary tasks.'Nanorobotics and nanodiagnostics'is a new generation of biohybrid that translates fundamental biological principles into engineering design rules to create biorobots that perform like natural systems. These biorobotics and diagnostics can now perform various missions to be accomplished certain tasks in the research areas such as integrative biology and biomedicine.'Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine'sheds light on a comprehensive overview of the multidisciplinary areas that explore nanotherapeutics and nanorobotic manipulation in biology and medicine. It provides up-to-date knowledge of the promising fields of integrative biology and biomedicine for nano-assisted biorobotics and diagnostics to detect and treat diseases that will enable new scientific discoveries.

This is the first book providing overview of magnetism in curved geometries, highlighting numerous peculiarities emerging from geometrically curved magnetic objects such as curved wires, shells, as well as complex three-dimensional structures. Extending planar two-dimensional structures into the three-dimensional space has become a general trend in multiple disciplines across electronics, photonics, plasmonics and magnetics. This approach provides the means to modify conventional and even launch novel functionalities by tailoring the local curvature of an object. The book covers the theory of curvilinear micromagnetism as well as experimental studies of geometrically curved magnets including both fabrication and characterization. With its coverage of fundamental aspects, together with exploration of numerous applications across magnonics, bio-engineering, soft robotics and shapeable magnetoelectronics, this edited collection is ideal for all scientists in academia and industry seeking an overview and wishing to keep abreast of advances in the novel field of curvilinear micromagnetism. It provides easy but comprehensive access to the field for newcomers, and can be used for graduate-level courses on this subject.

This book presents tools and techniques for the development of miniature biosensors and their applications. The initial chapters discuss the advancements in the development of the transduction techniques, including optical, electrochemical, and piezoelectric, which are used for miniaturized biosensors. The book also reviews several technologies, such as nanotechnology, nanobiotechnology, immune-technology, DNA-technology, micro-manufacturing technology, electronic-circuit technology to increase the miniaturization and sensitivity of the biosensor platform. Subsequently, the chapters illustrate the applications of miniaturized biosensing systems in point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics, and biomedical research. Towards the end, the book discusses the advanced applications of biosensors in water quality monitoring, especially on-line detection systems and on-site detection of pesticides, heavy metals and bacteria in water. This book is an invaluable source for scientists working in biochemical engineering, bioengineering, and biomedical engineering in academia and industry.

This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.

This Handbook covers the fundamentals of carbon nanotubes (CNT), their composites with different polymeric materials (both natural and synthetic) and their potential advanced applications. Three different parts dedicated to each of these aspects are provided, with chapters written by worldwide experts in the field. It provides in-depth information about this material serving as a reference book for a broad range of scientists, industrial practitioners, graduate and undergraduate students, and other professionals in the fields of polymer science and engineering, materials science, surface science, bioengineering and chemical engineering.Part 1 comprises 22 chapters covering early stages of the development of CNT, synthesis techniques, growth mechanism, the physics and chemistry of CNT, various innovative characterization techniques, the need of functionalization and different types of functionalization methods as well as the different properties of CNT. A full chapter is devoted to theory and simulation aspects. Moreover, it pursues a significant amount of work on life cycle analysis of CNT and toxicity aspects.Part 2 covers CNT-based polymer nanocomposites in approximately 23 chapters. It starts with a short introduction about polymer nanocomposites with special emphasis on CNT-based polymer nanocomposites, different manufacturing techniques as well as critical issues concerning CNT-based polymer nanocomposites. The text deeply reviews various classes of polymers like thermoset, elastomer, latex, amorphous thermoplastic, crystalline thermoplastic and polymer fibers used to prepare CNT based polymer composites. It provides detailed awareness about the characterization of polymer composites. The morphological, rheological, mechanical, viscoelastic, thermal, electrical, electromagnetic shielding properties are discussed in detail. A chapter dedicated to the simulation and multiscale modelling of polymer nanocomposites is an additional attraction of this part of the Handbook.Part 3 covers various potential applications of CNT in approximately 27 chapters. It focuses on individual applications of CNT including mechanical applications, energy conversion and storage applications, fuel cells and water splitting, solar cells and photovoltaics, sensing applications, nanofluidics, nanoelectronics and microelectronic devices, nano-optics, nanophotonics and nano-optoelectronics, non-linear optical applications, piezo electric applications, agriculture applications, biomedical applications, thermal materials, environmental remediation applications, anti-microbial and antibacterial properties and other miscellaneous applications and multi-functional applications of CNT based polymer nanocomposites. One chapter is fully focussed on carbon nanotube research developments: published papers and patents. Risks associated with carbon nanotubes and competitive analysis of carbon nanotubes with other carbon allotropes are also addressed in this Handbook.

This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare. ​

This interdisciplinary book covers the fundamentals of optical whispering gallery mode (WGM) microcavities, light–matter interaction, and biomolecular structure with a focus on applications in biosensing. Novel biosensors based on the hybridization of WGM microcavities and localized surface plasmon resonances (LSPRs) in metal nanoparticles have emerged as the most sensitive microsystem biodetection technology that boasts single molecule detection capability without the need for amplification and labeling of the analyte. The book provides an ample survey of the physical mechanisms of WGMs and LSPRs for detecting affinity, concentration, size, shape and orientation of biomarkers, while informing the reader about different classes of biomolecules, their optical properties and their importance in label-free clinical diagnostics.This expanded and updated second edition features a new chapter that introduces the reader to advanced in vivo biosensing techniques using WGM microcavities, looking at photothermal sensing, methods for trapping neutral atoms around WGM microcavities, and practical aspects of optoplasmonic sensing. The second Edition now provides a comprehensive introduction to the use of WGM microcavities in physical sensing which includes measurements with frequency combs, macro and micro (one atom) lasers, gyroscopes, optomechanical and parity-time-symmetric sensor devices.Chapter-end problems round out this comprehensive and fundamental textbook, inspiring a host of up-and-coming physicists, bioengineers, and medical professionals to make their own breakthroughs in this blossoming new field. This textbook can be used for both introductory and advanced courses about the modern optics of optical microcavities.

This book highlights contemporary state of research in multidisciplinary areas in computer science, computer engineering, chemical engineering, mechanical engineering, physics, biomedical sciences, life sciences, medicine, and health care. The accepted submissions to the 7th IRC Conference on Science, Engineering and Technology (IRC-SET 2021) that were presented on August 7, 2021, are published in this conference proceedings. The papers presented here were shortlisted after extensive rounds of rigorous reviews by a panel of esteemed individuals who are pioneers and experts in their respective domains.

Biomaterials are composed of metallic materials, ceramics, polymers, composites and hybrid materials. Biomaterials used in human beings require safety regulations, toxicity, allergic reaction, etc. When used as implantable materials their biological compatibility, biomechanical compatibility, and morphological compatibility must be acessed. This book explores the design and requirements of biomaterials for the use in implantology.

This contributed volume reviews the latest advances in all the new technologies currently developed for MagnetoEncephaloGraphy (MEG) recordings, as well as sensor technologies and integrated sensor arrays for on-scalp MEG. The book gives an account of the first MEG imaging studies and explores the new field of feasible, experimental paradigms of on-scalp MEG. This is an ideal book for engineers, researchers, and students in the neurosciences interested in MEG imaging.

This book presents cutting-edge research and developments in the field of biomedical engineering, with a special emphasis on achievements by Asian research groups. It covers machine learning and computational modeling methods applied to biomedical and clinical research, advanced methods for biosignal processing and bioimaging, MEMS applications, and advances in biosensors. Further topics include biomechanics, prosthetics, orthotics and tissue engineering. Other related (bio-) engineering applications, such as in ecosystem development, water quality assessment, and material research, are also covered. Gathering the proceedings of the 6th Kuala Lumpur International Conference on Biomedical Engineering, held online on July 28-29, 2021 from Kuala Lumpur, Malaysia, the book is intended to provide researchers and professionals with extensive and timely information on the state-of-the-art research and applications in biomedical engineering, and to promote interdisciplinary and international collaborations.

This book gathers the proceedings of the 5th International Conference on Nanotechnologies and Biomedical Engineering, held online on November 3–5, 2021, from Chisinau, Republic of Moldova. It covers fundamental and applied research at the interface between nanotechnologies and biomedical engineering. Chapters report on cutting-edge bio-micro/nanotechnologies, devices for biomedical applications, and advances in bio-imaging and biomedical signal processing, innovative nano-biomaterials as well as advances in e-health, medical robotics, and related topics. With a good balance of theory and practice, the book offers a timely snapshot of multidisciplinary research at the interface between physics, chemistry, biomedicine, materials science, and engineering.

This book provides a comprehensive presentation of the most frequently used high resolution manufacturing techniques available, as well as the polymeric materials used for each of the techniques. Divided into two parts covering the technologies and materials used and the impact on different research fields and case studies, High Resolution Manufacturing from 2D to 3D/4D Printing: Applications in Engineering and Medicine addresses issues like throughput improvement by volumetric 3D printing and presenting novel applications and case studies. In addition, this book also covers the latest breakthrough developments and innovations to help readers understand the future applications of this technology across various disciplines, including biomedicine, electronics, energy, and photonics.

This book provides an overview of the use of nanoparticles, carbon-nanotubes, liposomes, and nanopatterned flat surfaces for specific biomedical applications. This book explains the chemical and physical properties of the surface of these materials that allow their use in diagnosis, biosensing and bioimaging devices, drug delivery systems, and bone substitute implants. The toxicology of these particles is also discussed in the light of a new field referred to as nanotoxicology in this book. This book will be useful for engineers, researchers and industry professionals primarily in the fields of polymer science and engineering, materials science, surface science, nanocatalysis, biotechnology and biomedicine.

This book serves as an introduction to the concepts of medical biotechnology, with great details about fundamentals and early disciplines of study as well as emerging fields and the latest research. The book follows a chronological order from the earliest discoveries and breakthroughs of medical biotechnology to the latest areas of study. The book contains up-to-date citations for each chapter and section, which makes it easy for the reader to understand the concept and also to follow the latest developments in the particular area. It is an ideal book for undergraduate and graduate students who aspire to derive basic knowledge and are also keen on learning about the latest advancements in the field of medical biotechnology.

This book discusses advancements in the applications of nanoparticles in tissue engineering. It examines the applications of nanobiomaterials in hard tissue regeneration, fabrication, and characterization. The book also analyzes the implication of three-dimensional and four-dimensional fabrication techniques for the production of the scaffold in tissue engineering and their advantages over conventional scaffold production techniques. Further, it presents smart materials used in making 4-D scaffolds that imitate the dynamic response of tissue against natural stimuli and adapt to the microenvironment by changing their conformation or other properties. It also summarizes the growing field of biomolecular detection and biosensors in tissue engineering and the increasing prominence of nanoparticles in the biosensors. Further, it provides the future outlook and associated challenges of the application of nanomaterials in tissue engineering.

This textbook fills a gap to supply students with the fundamental principles and tools they need to perform the quantitative analyses of the neuroelectrophysiological approaches, including both conventional and emerging ones, prevalently used in neuroscience research and neuroprosthetics. The content grows out of a course on Neuroengineering and Neuroprosthetics, which the author has taught already several times. The key problems the author addresses include (1) the universal operating mechanisms of neuroelectrophysiological approaches, (2) proper configuration of each approach, and (3) proper interpretation of the resulting signals. Efforts are made both to extract the universal principles underlying this common class of approaches and discern the unique properties of each individual approach. To address these important problems, equivalent electrical circuit modeling and signal analysis are used to unravel the functioning mechanisms and principles and provide sound interpretations to the associated signals and phenomena. This book aims to derive analytical solutions to these equivalent circuits, which can offer clear and complete mechanistic insights to the underlying biophysics.

Nanoscience and nanotechnologies are leading to a major point to our understanding of nature. Nanotechnology can be generally defined as creation and use of nano-sized systems, devices, and structures which have special functions or properties because of their small size. This volume on Nanotechnology Applications in Health and Environmental Sciences focuses on biotechnological and environmental applications of nanomaterials. It covers popular and various nanomedical topics such as oncology, genetics, and reconstructive medicine. Additionally, many chapters give leading-edge information on nano-sensor applications and usage in specific disciplines. Also, two chapters on novel subjects have been included on Lantibiotics and microbiota. This book should be useful for nanotechnologists, microbiologists, and researchers interested in nanomedicine and nano-biotechnology, as well as environmental nanotechnology.

Innovation in healthcare is currently a “hot” topic. Innovation allows us to think differently, to take risks and to develop ideas that are far better than existing solutions. Currently, there is no single book that covers all topics related to microelectronics, sensors, data, system integration and healthcare technology assessment in one reference. This book aims to critically evaluate current state-of-the-art technologies and provide readers with insights into developing new solutions. With contributions from a fully international team of experts across electrical engineering and biomedical fields, the book discusses how advances in sensing technology, computer science, communications systems and proteomics/genomics are influencing healthcare technology today.

This book provides a brief overview of single-cell analysis using recent advanced technologies. The different sections cover different aspect of single cell analysis and applications with their advantages, limitations, and future challenges. The book has covered how different physical energies such as optical, electrical, and mechanical energy have been applied for single cell therapy and analysis. The recent advanced micro/nanofluidic devices have been employed for single-cell counting, manipulation, cultivation, separation, isolation, lysis, printing and patterning and host-viral interaction at single-cell level. Various chemical approaches for single-cell analysis have been discussed, such as liposome mediated materials transfer at single-cell and their analysis, discovery of antibody via single-cell, high-throughput screening of antigen-specific antibody-secreting cells, and biomolecular secretion analysis of individual cells. Moreover, different single-cell omics such asgenomics, proteomics and transcriptomics have been discussed using microfluidic technologies as well as conventional approaches. The role of single cell analysis in system biology and biocatalysis have been discussed in detail. The book describes single-cell phenotyping of heterogeneous tissue, stimulation, and instant reaction quenching technology for biochemical kinetic analysis, large scale single-cell assay for the identification of biocatalysts and analytical techniques for single-cell studies in microbiology. The role of single-cell analysis in cancer, such as single-cell adhesion and cancer progression, single-cell technologies for cancer therapy, analytical technology for single cancer cell analysis, and biophysical markers for cancer cell analysis have been discussed. The flow cytometry based high throughput single-cell analysis have been well emphasized. Finally this book has covered single-cell electrophysiology, single-cell sensing and size measurement using mechanical and microwave resonators, molecular force spectroscopy for cell adhesion measurement, micro-tweezers and force microscopy techniques for single-cell mechanobiological analysis, mass spectrometry and acoustic tweezers for single-cell manipulation and analysis. This book is intended for academic and industrial researchers, undergraduate and graduate students in the fields of biomedical engineering, bio-micro/nanoengineering, and bio-micro/nano fabrication for single-cell analysis. It can be used for courses on bio-MEMS/bio-NEMS, biomicrofluidics, bio-micro/nanofabrications, micro/nanofluidics, biophysics, single cell analysis, bionanotechnology, drug delivery systems and biomedical microdevices. Collective contributions from respected experts, have brought diverse aspects of single-cell technologies in a single hand book. This will benefit researchers and practitioners in the biotechnology industry for different diseases analysis, therapeutics, diagnostics, drug discovery, drug screening etc. In addition to hard copies, the book will be available online and will often be updated by the authors.

Nanotechnology has been established in membrane technology for decades. In this book, comprehensive coverage is given to nanotechnology applications in synthetic membrane processes, which are used in different fields such as water treatment, separation of gases, the food industry, military use, drug delivery, air filtration, and green chemistry. Nanomaterials such as carbon nanotubes, nanoparticles, and dendrimers are contributing to the development of more efficient and cost-effective water filtration processes. Gas separation and carbon capture can be significantly improved in flue gas applications. Nanoporous membrane systems engineered to mimic natural filtration systems are being actively developed for use in smart implantable drug delivery systems, bio artificial organs, and other novel nano-enabled medical devices. The microscopic structure of nanoporous ceramic membranes, mainly focusing on zeolite materials, as well as the energy-saving effect of membrane separation, contribute to various chemical synthesis processes. In the food industry, nanotechnology has the potential to create new tools for pathogen detection and packaging. For each application, nanotechnology is mostly used to make composite membranes, and the book provides a detailed look at the mechanisms by which the composite membrane works in each application area.

This book addresses conventional treatments of bone diseases. It proposes nanotechnological tools based on the use of silica as a bioactive material for bone. The book links the physiological and anatomical aspects of the bone with the ancestral importance of the bone system. It describes associated pathologies and conventional treatments, emphasizing their shortcomings. The book gives future perspectives and applicable tools to the development of new nanomaterials.