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The article presents a case study of a 20-year-old man who was taken to a clinic because of uncontrolled intraocular pressure (IOP). He had an increased IOP that had been detected seven years ago with the use of slit-lamp assisted biomicroscopy wherein it revealed a deep anterior chamber and a widely open anterior chamber angle at gonioscopy in both eyes. The patient's development of glaucomatous optic nerve damage may have his abnormally thick cornea or other cornea related factors.

A letter to the editor which discusses the effect of glucagon-like peptide produced intravitreally on retinal ganglion cell count in rats with optic nerve crush is presented.

Purpose To examine the effect of intraocularly produced glucagon‐like peptide‐1 (GLP‐1) on the survival rate of retinal ganglion cells in an optic nerve crush model. Methods Forty‐one Sprague‐Dawley rats were divided into a study group (21 animals) in which 4 beads with 3000 genetically modified cells to produce GLP‐1 were intravitreally implanted into the right eye; a saline control group (n=12) with intravitreal saline injection; and a GLP‐1 negative bead control group (n=8) in which 4 beads with 3000 cells without GLP‐1 production were intravitreally implanted. The right optic nerves of all animals were crushed in a standardized manner. After labeling the retinal ganglion cells by injecting 3% fluorogold into the superior colliculus, the animals were sacrificed, and the ganglion cells were counted on retinal flat mounts. Results The retinal ganglion cell density of the right eyes was significantly higher in the study group (2030±470 cells/mm2) than in the GLP‐1 bead negative control group (1390±367 cells/mm2;P=0.001) and than in the saline control group (1734±424 cells/mm2;P=0.07). Correspondingly, the survival rate (ratio of retinal ganglion cell density of right eye / left eye) was significantly higher in the study group (71±19%) than in the GLP‐1 bead negative control group (49±14%; P=0.003) and than in the saline control group (57±16%;P=0.03). Conclusion Glucagon‐like peptide‐1 produced by intravitreally implanted cell beads was associated with a higher survival rate of retinal ganglion cells after an experimental optic nerve crush in rats. Commercial interest [ABSTRACT FROM AUTHOR]