1. CAR-T cells secreting immune checkpoint antibodies relieve immunosuppression.
- Author
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Lv, Keyi
- Subjects
- *
IMMUNE checkpoint proteins , *IMMUNOGLOBULINS , *IMMUNOSUPPRESSION , *PROGRAMMED death-ligand 1 , *IMMUNOLOGICAL tolerance , *T cells , *PROGRAMMED cell death 1 receptors , *CYTOTOXIC T cells - Abstract
Tumor microenvironment (TME) plays a key role in tumor immune escape. PD-1/PD-L1 signal transduction pathway can achieve tumor immune escape by enhancing tumor cell immune tolerance and inhibiting the activation of T lymphocytes. In recent years, immunosuppression, as one of the many mechanisms of tumor immune escape, has also become a research hotspo. The optimized CAR-T cells released immunosuppression by secreting antibodies against checkpoint inhibitors. Therefore, CAR-T therapy targeting tumor micro environment and PD-1/PD-L1 pathway are important methods for cancer treatment. This paper summarizes the role of PD-1/PD-L1 signaling pathway in mediating tumor escape in tumor microenvironment, and briefly introduces CAR-T immunotherapy and its TME-related targets. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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