1. False-Positive Rates in Pediatric SARS-CoV-2 Serology Testing.
- Author
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Henry, Brandon Michael, Benoit, Stefanie W, Lippi, Giuseppe, Sabalza, Maite, Venkataraman, Iswariya, Geisler, Daniel, Freeman, Megan Culler, Rapsinski, Glenn J, and Wheeler, Sarah E
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COVID-19 , *SARS-CoV-2 , *MULTISYSTEM inflammatory syndrome in children , *VIRAL antibodies , *COVID-19 testing - Abstract
: Biological, Clinical, and Technical Considerations These considerations are important when performing serology studies, with anti-S1/S2 serology tests preferably used to assess true seroprevalence; anti-RBD-specific serology immunoassays may be better suited to reflecting the presence of neutralizing antibodies. We read with interest the report by Geisler et al[1] and commend the authors for their efforts to address the important need to evaluate the clinical performance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic assays in pediatric populations, especially with respect to serology, given the noted differences in immune responses between children and adults.[2] We do feel, however, that the title of this paper may be misleading. This behavior would make it challenging to define whether anti-RBD antibodies are false negatives or if anti-S1 antibodies are false positives. [Extracted from the article]
- Published
- 2022
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