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Start Over Author "Zhang, Quan" Search Limiters Peer Reviewed Topic cell-mediated cytotoxicity Journal bioorganic & medicinal chemistry letters Database Academic Search Index
2 results on '"Zhang, Quan"'

1. Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl)

Author

Zhang, Sai-Yang, Zhang, Quan-Hai, Zhao, Wen, Zhang, Xiao, Zhang, Qi, Bi, Yue-Feng, and Zhang, Yan-Bing

Subjects
*BENZOPHENONES, *GLUCOPYRANOSIDE, *THYMELAEACEAE, *CRYSTAL structure, *CANCER treatment, *CANCER cells, *CELL-mediated cytotoxicity
Abstract

Abstract: Two benzophenone glucopyranosides have been isolated from the nut shell part of Mahkota Dewa. The structures were identified as 2,4′,6-trihydroxy-4-methoxy-benzophenone-2-O-β-d-glucoside (Mahkoside A) and 2,4′,6-trihydroxy-4-methoxy-6″-acetyl-benzophenone-2-O-β-d-glucoside (Mahkoside B). Mahkoside B was recognized as a novel compound. Furthermore, a series of benzophenone glucopyranoside derivatives (compounds 3–18) were synthesized and their bioactivities were characterized. Our results demonstrated that compound 18 has significant cytotoxicity against two esophageal cancer cell lines, stomach cancer cell line and prostate cancer cell line, with IC50 less than 10μM, indicating its potential activity against cancer cells. [Copyright &y& Elsevier]

Published
2012
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2. Anti-HBV agents. Part 2: Synthesis and in vitro anti-hepatitis B virus activities of alisol A derivatives

Author

Zhang, Quan, Jiang, Zhi-Yong, Luo, Jie, Liu, Ji-Feng, Ma, Yun-Bao, Guo, Rui-Hua, Zhang, Xue-Mei, Zhou, Jun, and Chen, Ji-Jun

Subjects
*ANTIVIRAL agents, *HEPATITIS B virus, *STRUCTURE-activity relationship in pharmacology, *CELL-mediated cytotoxicity, *DRUG activation, *CELL surface antigens
Abstract

Abstract: Chemical modifications were performed on hydroxyl groups at C-11,23,24,25 positions and C-13(17) double bond of alisol A for structure–activity relationship study. Forty-one derivatives of alisol A were synthesized and assayed for their in vitro anti-hepatitis B virus (HBV) activities and cytotoxicities. Of them, 14 compounds were active against HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) secretion in HepG 2.2.15 cells, and the most promising compound 25 exhibited high activities against secretion of HBsAg (IC50 =0.028mM), HBeAg (IC50 =0.027mM) and remarkable selective indices (SIHBsAg >90, SIHBeAg >93). [Copyright &y& Elsevier]

Published
2009
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