1. Bioactive polyoxygenated seco-cyclohexenes from Artabotrys hongkongensis.
- Author
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Liu, Yan-Ping, Tang, Jin-Ying, Hua, Yan, Lai, Liang, Luo, Xiu-Lan, Zhang, Zhi-Jie, Yin, Wen-Qing, Chen, Guang-Ying, and Fu, Yan-Hui
- Subjects
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ANNONACEAE , *BIOACTIVE compounds , *ANTINEOPLASTIC agents , *NUCLEAR magnetic resonance spectroscopy , *CELL lines , *PHYSIOLOGY - Abstract
Six new polyoxygenated seco-cyclohexenes, artahongkongenes A–F ( 1–6 ), together with six known analogues ( 7–12 ) were isolated from the stems and leaves of Artabotrys hongkongensis . Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro . New seco-cyclohexenes 1–6 showed significant inhibitory effects against various human cancer cell lines with IC 50 values ranging from 0.26 to 16.58 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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