1. Mitochondrial control of antigen presentation in cancer cells.
- Author
-
Soler-Agesta, Ruth, Anel, Alberto, and Galluzzi, Lorenzo
- Subjects
- *
ANTIGEN presentation , *CANCER cells , *T cell receptors , *MITOCHONDRIA , *T cells - Abstract
Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism. Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF