1. PD-1 immune cell infiltration inversely correlates with survival of operable breast cancer patients.
- Author
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Sun, Shenyou, Fei, Xiaochun, Mao, Yan, Wang, Xiumin, Garfield, David, Huang, Ou, Wang, Jinglong, Yuan, Fei, Sun, Long, Yu, Qixiang, Jin, Xiaolong, Wang, Jianhua, and Shen, Kunwei
- Subjects
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BREAST cancer patients , *CELLULAR immunity , *CANCER immunotherapy , *ANTINEOPLASTIC agents , *GENE expression , *BREAST cancer treatment - Abstract
The programmed death-1 (PD-1) molecule is mainly expressed on functionally 'exhausted' CD8 T cells, dampening the host antitumor immune response. We evaluated the ratio between effective and regulatory T cells (Tregs) and PD-1 expression as a prognostic factor for operable breast cancer patients. A series of 218 newly diagnosed invasive breast cancer patients who had undergone primary surgery at Ruijin Hospital were identified. The influence of CD8 cytotoxic T lymphocytes, FOXP3 (Treg cell marker), and PD-1 immune cell counts on prognosis was analyzed utilizing immunohistochemistry. Both PD-1 immune cells and FOXP3 Tregs counts were significantly associated with unfavorable prognostic factors. In bivariate, but not multivariate analysis, high tumor infiltrating PD-1 cell counts correlated with significantly shorter patient survival. Our results suggest a prognostic value of the PD-1 immune cell population in such breast cancer patients. Targeting the PD-1 pathway may be a feasible approach to treating patients with breast cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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