1. Biphasic water–oil systems for functional augmentation of probiotic Lactobacillus acidophilus nanoencapsulated in luteolin-Fe3+ shells.
- Author
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Nguyen, Duc Tai, Han, Sang Yeong, Kozlowski, Filip, Seisenbaeva, Gulaim A., Kessler, Vadim G., Kim, Beom Jin, and Choi, Insung S.
- Subjects
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LACTOBACILLUS acidophilus , *PROBIOTICS , *HYDROPHILIC compounds , *ORGANIC solvents , *LUTEOLIN , *AMYLASES , *LYSOZYMES - Abstract
Single-cell nanoencapsulation (SCNE) has great potential in the enhancement of therapeutic effects of probiotic microbes. However, the material scope has been limited to water-soluble compounds to avoid non-biocompatible organic solvents that are harmful to living cells. In this work, the SCNE of probiotic Lactobacillus acidophilus with water-insoluble luteolin and Fe3+ ions is achieved by the vortex-assisted, biphasic water–oil system. The process creates L. acidophilus nanoencapsulated in the luteolin-Fe3+ shells that empower the cells with extrinsic properties, such as resistance to lysozyme attack, anti-ROS ability, and α-amylase-inhibition activity, as well as sustaining viability under acidic conditions. The proposed protocol, embracing water-insoluble flavonoids as shell components in SCNE, will be an advanced add-on to the chemical toolbox for the manipulation of living cells at the single-cell level. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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