1. Triazine-pyridine chemistry for protein labelling on tyrosine.
- Author
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Jiang, Hongfei, Zhang, Qing, Zhang, Yue, Feng, Huxin, Jiang, Hao, Pu, Fan, Yu, Rilei, Zhong, Zheng, Wang, Chaoming, Fung, Yi Man Eva, Blasco, Pilar, Li, Yongxin, Jiang, Tao, and Li, Xuechen
- Subjects
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TYROSINE , *NITRATION , *PROTEINS , *TRIAZINES , *BIOLOGICAL systems , *CYSTEINE , *CHEMOSELECTIVITY - Abstract
Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems after cysteine blocking, displayed potential in tyrosine-guided protein labelling, and had bio-compatibility in live cells. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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