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We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model. [ABSTRACT FROM AUTHOR]

Structurally unmatched hyperthin (14 nm) polyelectrolyte multi-layers (PEMs) formed on poly[1-(trimethylsilyl)-1-propyne] supports exhibit exceptionally high CO2/N2 permeation selectivities, ranging from 100 to 150. Structurally matched PEMs show similar selectivities with significantly higher permeances. [ABSTRACT FROM AUTHOR]

Single Langmuir–Blodgett (LB) bilayers derived from calix[n]arene-based surfactants (n= 4, 5 and 6) and poly(acrylic acid) (PAA) exhibit exceptional H2/CO2permeation selectivities. Evidence for the importance of ionic crosslinking and self-healing processes is presented. [ABSTRACT FROM AUTHOR]

A tumor-targeting therapy strategy is urgently needed to increase the accumulation of drugs in tumors and reduce the side effects in normal tissues. Herein, we developed an esterase-activatable curcumin prodrug Cur-RGD for tumor-targeting therapy. Armed with the tumor-targeting RGD peptide and in situ esterase-triggered drug release, this prodrug Cur-RGD can efficiently improve the therapeutic effect of curcumin in tumors. [ABSTRACT FROM AUTHOR]

We have proposed a simple electrochemical method in this work for the assay of tumor cells through their own steric hindrance effect. Specifically, tumor cells can block the catalysis of terminal deoxynucleotidyl transferase to the aptamer previously immobilized on the electrode surface. By making use of the hindrance effect, cancer cells can be quantitatively analyzed in the range from 1.6 × 102 to 1.6 × 106 cells per mL without complicated design or cumbersome operation, while the detection limit can be about 53 cells per mL. This method can also show satisfactory performance in complex environments, indicating its potential in clinical application. [ABSTRACT FROM AUTHOR]

Exosomes have been widely considered as excellent noninvasive or minimally invasive biomarkers; however, the currently available methods for exosome detection usually need sophisticated instruments, or the sensitivity cannot be satisfactory, since the size of exosomes is very large. Nevertheless, in this work, by making use of the steric hindrance of exosomes due to their large size, we have developed a simple and sensitive method for the detection of exosomes with great potential in clinical use. [ABSTRACT FROM AUTHOR]

A novel and reversible single-material solvent-sensitive actuator was developed from poly(ionic liquid) inverse opals based on a gradient wetting/dewetting process combining the strong hydrogen bonding interaction between the solvent and polymer. This study will provide an important insight for the design and fabrication of novel-type solvent-actuator materials. [ABSTRACT FROM AUTHOR]