1. Toll-like receptor 10 expression in B cells is negatively correlated with the progression of primary Sjögren's disease.
- Author
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Lai, Nannan, Qian, YiChao, Wu, Yilin, Jiang, Xi, Sun, Honghua, Luo, Zhaofan, Zhao, Yanli, Zeng, Changchun, Zheng, Xiaoming, Zhan, Xiao-Yong, Tang, Chun, Wang, Qingwen, and Huang, Bihui
- Subjects
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B cells , *TOLL-like receptors , *IMMUNOLOGIC memory - Abstract
Primary Sjögren's Disease (pSjD) is considered a B cell-mediated disease. Toll-like receptor 10 (TLR10) is highly expressed in human B cells, indicating that TLR10 probably plays a vital role in pSjD. We examined TLR10 expression in peripheral B subsets of pSjD patients and analyzed their association with disease activity. We observed that TLR10 expression in total, naïve, memory, and switched memory B cells was significantly increased in low-activity pSjD patients as compared with healthy controls and high-activity patients. TLR10 expression in the above mentioned B subsets (except naïve B) was negatively correlated with serum levels of anti-SSA antibody and BAFF, respectively. Moreover, a higher proportion of high-activity pSjD patients was observed in TLR10 low- than high-expressed patients. Our study concluded that TLR10 expression in CD19+ B and memory B was negatively correlated with pSjD disease activity, suggesting that TLR10 might take part in the progression of pSjD. • Upregulated expression of TLR10 in switched memory B in pSjD patients. • TLR10 expression is reduced in B subsets in high-activity pSjD patients. • Expression of TLR10 in B subsets is negatively correlated with anti-SSA and BAFF. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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