1. ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2.
- Author
-
Fragkou, Paraskevi C., De Angelis, Giulia, Menchinelli, Giulia, Can, Fusun, Garcia, Federico, Morfin-Sherpa, Florence, Dimopoulou, Dimitra, Mack, Elisabeth, de Salazar, Adolfo, Grossi, Adriano, Lytras, Theodore, and Skevaki, Chrysanthi
- Subjects
- *
COVID-19 testing , *MEDICAL personnel , *NUCLEIC acid amplification techniques , *SYMPTOMS , *PHYSIOLOGICAL adaptation - Abstract
The objective of these guidelines is to identify the most appropriate diagnostic test and/or diagnostic approach for SARS-CoV-2. The recommendations are intended to provide guidance to clinicians, clinical microbiologists, other health care personnel, and decision makers. An ESCMID COVID-19 guidelines task force was established by the ESCMID Executive Committee. A small group was established, half appointed by the chair and the remaining selected with an open call. Each panel met virtually once a week. For all decisions, a simple majority vote was used. A list of clinical questions using the PICO (population, intervention, comparison, outcome) format was developed at the beginning of the process. For each PICO, two panel members performed a literature search focusing on systematic reviews, with a third panellist involved in case of inconsistent results. Quality of evidence assessment was based on the GRADE-ADOLOPMENT (Grading of Recommendations Assessment, Development and Evaluation - adoption, adaptation, and de novo development of recommendations) approach. A total of 43 PICO questions were selected that involve the following types of populations: (a) patients with signs and symptoms of COVID-19; (b) travellers, healthcare workers, and other individuals at risk for exposure to SARS-CoV-2; (c) asymptomatic individuals, and (d) close contacts of patients infected with SARS-CoV-2. The type of diagnostic test (commercial rapid nucleic acid amplification tests and rapid antigen detection), biomaterial, time since onset of symptoms/contact with an infectious case, age, disease severity, and risk of developing severe disease are also taken into consideration. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF