1. IL-15: targeting CD8 + T cells for immunotherapy.
- Author
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Diab, A., Cohen, A. D., Alpdogan, O., and Perales, M.-A.
- Subjects
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IMMUNE system , *CYTOKINES , *MACROPHAGES , *NEUTROPHILS , *HOMEOSTASIS , *IMMUNOTHERAPY , *VACCINATION , *T cells , *IMMUNOLOGICAL adjuvants - Abstract
IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8 + T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper, we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8 + T cells. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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