1. Health-related quality of life of children and adolescents with cerebral palsy in low- and middle-income countries: a systematic review.
- Author
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Power, Rosalie, King, Catherine, Muhit, Mohammad, Heanoy, Eamin, Galea, Claire, Jones, Cheryl, Badawi, Nadia, and Khandaker, Gulam
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CHILDREN with cerebral palsy , *DEVELOPMENTAL disabilities , *CHILD development , *CEREBRAL palsy , *PEDIATRIC neurology , *DIAGNOSIS , *POVERTY & psychology , *MENTAL health , *QUALITY of life , *QUESTIONNAIRES , *SYSTEMATIC reviews , *BIBLIOGRAPHIC databases , *PSYCHOLOGY - Abstract
Aim: To systematically review literature on health-related quality of life (HRQoL) of children and adolescents (≤18yo) with cerebral palsy (CP) from low- and middle-income countries (LMICs) to identify trends in HRQoL and areas for future research.Method: We systematically reviewed six key bibliographic databases and two reviewers independently screened results. Peer-reviewed original articles examining HRQoL of children from LMICs were eligible.Results: A total of 22 524 papers were identified, of which 16, from eight LMICs, were included. Four measures of HRQoL were used; Child Health Questionnaire Parent Form 50 (n=5); Paediatric Quality of Life Inventory 3.0 and 4.0 (n=4); CP Quality of Life Questionnaire for Children (n=4); Lifestyle Assessment Questionnaire CP (n=3). Children with CP from LMICs (n=1579; 2-18y) had significantly poorer HRQoL on all instrument dimensions when compared to age-matched controls (p<0.003) and on all except two dimensions when compared to peers in high-income countries (p<0.001). Physical well-being dimensions of HRQoL were poorest overall and associated with impaired motor function.Interpretation: Research to improve HRQoL in LMICs is required and should address all aspects of HRQoL. Future research is recommended to incorporate multi-respondent assessment, utilize both general and CP-specific measures of HRQoL, and delineate adolescents as a unique cohort. What this paper adds Children with cerebral palsy from low- and middle-income countries are at high risk of poor health-related quality of life (HRQoL). Physical well-being was poorest dimension of HRQoL and associated with impaired motor function. [ABSTRACT FROM AUTHOR]- Published
- 2018
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