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Disaster management is one of the most important actions to protect the property and lives of the victims. Failure to pay attention to logistical decisions of disaster can have irreversible consequences. Therefore, a multiechelon mathematical model for blood supply chain management in disaster situations is proposed in this research. The proposed supply chain includes supplier, central warehouse, reliable distributor, unreliable distributor, distributor, and affected areas. How the proposed model performs is explained as follows: blood is sent from the supplier to warehouses and distribution centers. Also, the capacity of suppliers is limited. The main objective of the mathematical model is to minimize supply chain costs while maximizing the level of satisfaction in order to meet the demand of the affected area. Hence, this research seeks to decide whether or not to establish a reliable distributor, unreliable distributor, and central warehouse. The amount of blood sent to the centers will also be calculated. One of the contributions of the proposed model is to consider the pre- and postdisaster modes simultaneously. Locating and investigating the flow between centers are also the other contributions of this study. Solving the proposed model using a robust optimization approach is another innovation taken into account in this research. The proposed model is solved using robust optimization, and finally, the results indicate the proper performance of the proposed model. [ABSTRACT FROM AUTHOR]