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• Genetic Algorithm (GA) based on Non-dominated Sorting Genetic Algorithm 2 (NSGA2) method is used for optimization. • Building optimization using passive design strategies can reduce final HVAC energy use 32% • Building optimization using passive design strategies can reduce time-integrated discomfort 46% • Overheating in nearly Zero Energy Buildings will be aggravated with continuation of global warming. • Building thermal comfort optimization does not ensure overheating mitigation during unprecedented events. It is expected that heatwaves will strike more frequently and with higher temperatures with the continuation of global warming. More extreme heatwaves concurrent with disruptions in the cooling system can lead to significant overheating problems in buildings affecting occupants' health, productivity, and comfort. This paper projects current and future heatwaves on an optimized nearly Zero-Energy terraced dwelling in Brussels, assuming the outage of the cooling system. Initially, a multi-objective optimization is performed considering 13 passive design strategies using the Genetic Algorithm (GA) based on the Non-dominated Sorting Genetic Algorithm 2 (NSGA-II) method. It is found that high ventilation rate, low infiltration rate, high insulation, high thermal mass, integration of green roof, and application of operable roller blinds are beneficial in reducing the final HVAC energy use up to 32% and enhancing thermal comfort up to 46%. Subsequently, three optimal solutions are selected and analyzed under the highest maximal temperature heatwaves detected during the 2001–2020, 2041–2060, and 2081–2100 periods. It is found that non of the optimal solutions are able to fully suppress overheating during heatwaves and the cooling system outage. The indoor operative temperatures reach more than 29 ° C , which can cause serious health issues for the occupants. The situation will be exacerbated in the future since an increase in maximum Heat Index (HI) between 0.28 °C and 0.49 °C, an increase in the maximum operative temperature between 1.34 ° C and 2.33 ° C , and a decrease in Thermal Autonomy (TA) between 17% and 28% are estimated. Finally, some recommendations are provided for practice and future research. [ABSTRACT FROM AUTHOR]

• Investigated climate change impacts on office building performance in Brussels. • Applied a long-term climate change sensitive system sizing and design approach. • Time-integrated discomfort analysis showed a major surge in overheating by 2100. • Long-term climate change resistivity is ensured in reference building until 2100. • Primary energy use and GHG emission findings are useful in mixed humid climates. As climate change continues, it is expected that the risk of overheating will rise in both new and existing buildings in mixed humid climate zones in Europe. This study introduced a novel climate change sensitive sizing and design approach for cooling and heating systems in nearly zero-energy office buildings in Brussels, Belgium, for different weather scenarios. This approach considered the long-term effects of climate change on building performance. The climate change effects were assessed using current and future climate data from the regional atmospheric model, MAR. To demonstrate the approach, a case study of a nearly zero-energy office building in Brussels was conducted. The reference building model was first calibrated using monthly energy use data from the year 2019 using ASHRAE Guideline 14. Then, the building was evaluated with different HVAC strategies and their performances were quantified. The results indicated an increase in overheating as high as 1.2 °C and cooling energy use as high as 13.5 kWh/m2 and a decrease in overcooling as low as 0.3 °C and heating energy use as low as 10.9 kWh/m2 in the reference building by the end of the century. In addition, due to climate change sensitive sizing and design approach coupled with optimal sizing, the reference building was climate change resistant towards the worst-case scenario by end of the century with up to 3.7 for climate change overheating resistivity and 20.2 for climate change overcooling resistivity. Finally, the paper provided recommendations for future practice and research based on the study findings. [ABSTRACT FROM AUTHOR]