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The paper provides some empirical evidence of the effectiveness of the “open innovation” model in the life science cluster of Emilia Romagna (a region of Italy), comparing the network of R&D collaborative activities in public research organizations (PROs) and the network linked to R&D collaborative activities in private firms. By presenting the main results of a field research in the life science sector in Emilia Romagna, we are contributing to the recent debate focused on the crises of the old “closed innovation” model and the rise of the “open innovation” model. Our survey consists of both primary data deriving from face-to-face interviews with researchers and entrepreneurs, and secondary data extracted from the Internet, the PubMed database, and from the European Patent Office. Our work is based on the analysis of a representative sample of 30 research groups in PROs, 2173 scientific articles published by the interviewed scientists, and a representative sample of 78 private firms. [ABSTRACT FROM AUTHOR]