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1. P2X7/ PANX1 as a new target for melanoma?

Author

Mantel, Alon and Harvey, Valerie

Subjects
*PANNEXINS, *MELANOMA treatment, *METASTASIS, *CANCER cell proliferation, *INFLAMMATION
Abstract

The article discusses the role of P2X7 receptors and Pannexin 1 (PANX1) proteins in melanoma. Topics discussed include association of chronic inflammation with melanoma progression, role of P2X7 in inflammasome activation, pro-metastatic effects of interleukin IL-1β, and investigation of inflammasome- mediated pathways to treat melanoma.

Published
2015
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