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Highlights • The Primary Heat Transfer System of the HCPB Breeding Blanket for the DEMO reactor has been preliminary designed. • A thermo-hydraulic assessment of Ex-Vessel PHTS has been carried out in order to size its main components. • Results show that HCPB BB PHTS is characterized by large IHXs heat transfer area, high coolant inventory, huge pumping power. • Further efforts are needed to reduce PHTS pressure drops and volumes as well as to improve IHXs performance. Abstract The European DEMO conceptual design foresees four Breeding Blanket (BB) concepts that rely on different cooling and breeding technologies. As DEMO has been conceived to deliver net electricity to the grid, the choice of the blanket coolant plays a pivotal role in the reactor design having a strong influence on plant operation, safety and maintenance. Moreover, the machine pulsed operation makes the BB Primary Heat Transfer System (PHTS) the main hub of the DEMO Balance of Plant (BoP). Within this framework, a study has been carried out to design the Ex-Vessel PHTS of the Helium-Cooled Pebble Bed (HCPB) BB concept. The paper describes criteria and rationale followed with the aim to achieve a simple PHTS design based on the adoption of easy-to-manufacture main components. Results of preliminary thermal-hydraulic calculations carried out to size heat exchangers, piping and compressors are presented and critically discussed. Finally, the evaluation of PHTS key parameters as total pressure drops and total coolant inventory is reported to provide input relevant to the assessment of the impact of helium technology on the design integration and feasibility of DEMO BoP. [ABSTRACT FROM AUTHOR]