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Highlights • A CO 2 -cooled FW has been proposed in this paper. • A high heat flux with radiation heat flux and particle heat flux has been applied on FW. • Different wall roughness position of channel has been shown. • Different wall roughness value has been given. • Sensitivity particle heat flux has been studied in this paper. Abstract The Demonstration Fusion Reactor in Europe (EU-DEMO) is considered to be the last step before building a commercial fusion power plant. Up to now, He has been chosen as gas coolant for three of the four candidate breeding blankets proposed for the EU-DEMO, being the Helium Cooled Pebble Bed (HCPB) among them. The choice of He coolant is supported, among other features, by its superior heat transfer capabilities, its transparency to neutrons and chemical inertness. However, the use of this coolant in DEMO poses some feasibility questions, like the large coolant inventory, resulting in possible safety issues, as well as the large circulating power. On the other side, CO 2 has been the fluid coolant choice in the nuclear fission industry for gas-cooled reactors since the 1950s. The key advantage of this gas is its larger density, which results in more compact components, lower coolant inventories, lower circulating powers and thus better plant thermal efficiency. This, coupled also with a relatively high molecular stability at moderate temperatures (up to 600 °C), its larger availability and lower price make CO 2 an attractive coolant for a pebble bed breeding blanket, as an alternative to He. As a Plasma Facing Component, the First wall (FW) is one of the components under the most challenging environment. Currently, the FW region at the upper port inboard location is expected to suffer the most critical heat flux loads. Indeed, a peak charged particle heat flux 0.99 MW/m2 together with a radiation heat flux of 0.18 MW/m2 is foreseen at this location. This paper reports the thermal-hydraulic analyses carried out to find the practical heat flux limits by using CO 2 as coolant. The analyses have been performed by using the commercial computational fluid dynamics (CFD) code ANSYS CFX. Different augmented technical wall roughness areas have been considered, for a best heat transfer-to-pressure drop ratio. Sensitivity analyses have been performed as well for higher peak particle heat fluxes, evidencing that a CO 2 -cooled FW can dissipate peak heat fluxes up to 1.8 MW/m2 keeping the circulator power in a reasonable range. [ABSTRACT FROM AUTHOR]