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Operational indices optimization is crucial for the global optimization in beneficiation processes. This paper presents a multitasking multiobjective evolutionary method to solve operational indices optimization, which involves a formulated multiobjective multifactorial operational indices optimization (MO-MFO) problem and the proposed multiobjective MFO algorithm for solving the established MO-MFO problem. The MO-MFO problem includes multiple level of accurate models of operational indices optimization, which are generated on the basis of a data set collected from production. Among the formulated models, the most accurate one is considered to be the original functions of the solved problem, while the remained models are the helper tasks to accelerate the optimization of the most accurate model. For the MFO algorithm, the assistant models are alternatively in multitasking environment with the accurate model to transfer their knowledge to the accurate model during optimization in order to enhance the convergence of the accurate model. Meanwhile, the recently proposed two-stage assortative mating strategy for a multiobjective MFO algorithm is applied to transfer knowledge among multitasking tasks. The proposed multitasking framework for operational indices optimization has conducted on 10 different production conditions of beneficiation. Simulation results demonstrate its effectiveness in addressing the operational indices optimization of beneficiation problem. Note to Practitioners—Operational indices optimization is a typical approach to achieve global production optimization by efficiently coordinating all the indices to improve the production indices. In this paper, a multiobjective multitasking framework is developed to address the operational indices optimization, which includes a multitasking multiobjective operational indices optimization problem formulation and a multitasking multiobjective evolutionary optimization to solve the above-formulated optimization problem. The proposed approach can achieve a solution set for the decision-making. The simulation results on a real beneficiation process in China with 10 operational conditions show that the proposed approach is able to obtain a superior solution set, which is associated with a higher grade and yield of the product. [ABSTRACT FROM AUTHOR]