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High-voltage (HV) pulse generators (PGs) are the core of pulsed electric field applications. Applying HV pulses produces electrical pores in a biological cell membrane, in which if the size of the pores increases beyond a critical size, the cell will not survive. This paper proposes a new HV-PG based on the modular multilevel converter with full-bridge submodules (FB-SMs). In order to alleviate the need of complicated sensorless or sensor-based voltage balancing techniques for the FB-SM capacitors, a dedicated self-regulating charging circuit is connected across each FB-SM capacitor. The individual capacitor charging voltage level is obtained from three successive stages, namely, convert the low-voltage dc input voltage to a high-frequency square ac voltage, increase the ac voltage level via a nanocrystalline step-up transformer, and rectify the secondary transformer ac voltage via a diode FB rectifier. The HV bipolar pulses are formed across the load in a fourth stage through series connected FB-SMs. The flexibility of inserting and bypassing the FB-SM capacitors allows the proposed topology to generate different pulse-waveform shapes, including rectangular waveforms with specifically reduced dv/dt and ramp pulses. The practical results, from a scaled-down experimental rig with five FB-SMs and a 1-kV peak-to-peak pulse output, validate the proposed topology. [ABSTRACT FROM PUBLISHER]

High-voltage (HV) pulses are used in pulsed electric field (PEF) applications to provide an effective electroporation process, a process in which harmful microorganisms are disinfected when subjected to a PEF. Depending on the PEF application, different HV pulse specifications are required such as the pulse-waveform shape, the voltage magnitude, the pulse duration, and the pulse repetition rate. In this paper, a generic pulse-waveform generator (GPG) is proposed, and the GPG topology is based on half-bridge modular multilevel converter (HB-MMC) cells. The GPG topology is formed of four identical arms of series-connected HB-MMC cells forming an H-bridge. Unlike the conventional HB-MMC-based converters in HVdc transmission, the GPG load power flow is not continuous which leads to smaller size cell capacitors utilization; hence, smaller footprint of the GPG is achieved. The GPG topology flexibility allows the controller software to generate a basic multilevel waveform which can be manipulated to generate the commonly used PEF pulse waveforms. Therefore, the proposed topology offers modularity, redundancy, and scalability. The viability of the proposed GPG converter is validated by MATLAB/Simulink simulation and experimentation. [ABSTRACT FROM PUBLISHER]