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This document is an editorial from the International Journal of Molecular Sciences that discusses the importance of molecular biology in various fields, including forensic science. It highlights advancements in molecular biology techniques that have improved forensic investigations, paternity disputes, and the identification of missing persons. The editorial also mentions potential future developments in forensic molecular biology, such as next-generation sequencing and microRNA analysis. The Special Issue includes ten articles that cover topics such as post-mortem interval determination, sampling methods in forensic genetics, DNA methylation-based age prediction, and the use of animal genomics in forensic science. The articles provide new findings and contribute to the advancement of molecular biology applications in forensic science. The editorial concludes by emphasizing the need for future research efforts and standardized protocols and guidelines in the field. [Extracted from the article]