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Reliability is a vital issue in the area of communication. In this paper, we particularly investigate the reliability issue for molecular communication based on drift diffusion (MCD2). Since molecules easily accumulate in the channel to produce strong internal symbol interference (ISI), the receiver nanomachine will generate high bit error rate (BER) for the process of decode information. Based on this problem, on the premise of considering channel diffusion noise and ISI noise, the expression of channel BER is deduced to analyze reliability. Then a ratio detection algorithm (RDA) is proposed to reduce BER to improve the reliability performance that enables the receiver nanomachine to adapt the channel condition. Furthermore, an expression of signal to interference plus noise ratio is defined in numerical simulation to verify our goal with different parameters, as well as with the adoption of RDA. The results indicate that the performance of RDA in reducing BER works well in general case in improving reliability performance for MCD2. [ABSTRACT FROM AUTHOR]