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COVID-19 has had a huge impact on many industries around the world. Internationally-funded enterprises have been greatly affected by COVID-19 prevention and control measures, such as border controls. However, few studies have examined the impact of COVID-19 on internationally-funded enterprises. To this end, this paper considered 12 of China's industrial parks situated in Southeast Asia, while comparing the operation status before and after the outbreak of COVID-19 based on remote sensing of nighttime lights (NTL). The NTL is generally used as a proxy for economic activity. First, six parameters were proposed to quantify and monitor the operation status based on NTL data. Subsequently, these parameters were calculated for the parks and for 10 km buffer zones surrounding them to analyze the differences in operating conditions. The results showed that (1) despite the negative impact of COVID-19, 9 out of the 12 parks had a mean NTL greater than 1, indicating that these parks are in better operating condition in 2020 than 2019; (2) 7 out of the 10 km buffer zones around the parks showed a decline in mean NTL. Only three parks showed a decline in mean NTL. The impact of COVID-19 on surrounding areas was greater than the impact on parks. [ABSTRACT FROM AUTHOR]