Search

Three new minor oleanane triterpenoid saponins, cylindrosides B (1), C (2), and D (3), were isolated from the seed of Cylindrokelupha dalatensis using chromatographic method. Their structures were established on the basis of the chemical and spectroscopic evidences. They displayed significant antitumor activity in vitro against HL60 cancer cell lines and IC50 values were 7.15 ± 0.63, 10.07 ± 0.97, and 4.74 ± 0.57 μM, respectively, by MTT method. [ABSTRACT FROM AUTHOR]

Fifteen cycloartane triterpenes were isolated from Beesia calthaefolia and among them one was new cycloartane triterpenoid. The structure of new compound was determined by the application of spectroscopic analyses and chemical methods. The fifteen compounds were evaluated for their anticomplement activity by classic pathway. The structure–activity relationship analysis indicated that the configurations of 12-OH is preferable to be α than β, and 18-OH can decrease while 15-OH can increase the anticomplement activity, but saponin with both 15-OH and 18-OH lost most of its activity. The glycosyl moiety of most isolated cycloartane triterpenes is xylosyl. When xylosyl was substituted by glucosyl or galactosyl, their anticomplement activities were decreased or increased, respectively. Further structure–activity relationship (SAR) studies must be carried out to achieve general conclusions regarding the effect of further functionalizations on the anticomplement saponins. [ABSTRACT FROM AUTHOR]

Compound 1, a triterpenoid saponin from Ardisia gigantifolia Stapf. showing potential anti-tumor activity, was transformed into three derivatives (2–4) by Aspergillus avenaceus 3.4454. Among them, compounds 2 and 3 are new compounds. Their structures were elucidated on the basis of 1D NMR, 2D NMR, HR-ESI-MS, and optical rotation data. Compounds 1–3 were evaluated for their cytotoxicity against human hepatocellular carcinoma and normal liver cells by cell counting kit 8 colorimetric assay. Compound 3 displayed better cytotoxicity against Bel-7402 and HepG2 cell lines and much weaker cytotoxicity against normal liver L02 cell than that of positive control (epirubicin hydrochloride). [ABSTRACT FROM AUTHOR]

Two new isoflavone glycosides, millesianins F (1) and G (2), along with 11 known ones (3–13) have been isolated from then-butanol extract of the vine stems ofMillettia dielsianaHarms. The structures of1and2were established as cladrastin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (1) and fujikinetin 7-O-β-d-apiofuranosyl-(1 → 6)-β-d-glucopyranoside (2) by means of spectroscopic analysis and chemical methods. Some isolates (compounds1,3,4,5,6, and11) were tested for their effects on the proliferation of hematopoietic progenitor cell, and the preliminary results showed that all of investigated compounds had moderate activities but not in dose-dependent manners. [ABSTRACT FROM PUBLISHER]

A new triterpenoid saponin, named cylindroside A (1), was isolated from the seeds ofCylindrokelupha dalatensis(Kosterm.) T.L. Wu by using chromatographic method. The structure of1was established by comprehensive spectroscopic analysis and chemical degradation. Compound1displayed significant antitumor activityin vitroagainst BCG and MCF-7 cancer cell lines and IC50values were 4.17 ± 0.23 and 3.07 ± 0.66 μM by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method, respectively. [ABSTRACT FROM PUBLISHER]

A new triterpenoid saponin, named 3-O-β-d-glucopyranosyl-(1 → 3)-β-d-xylopyranosyl-(1 → 2)-[α-l-rhamnopyranosyl-(1 → 3)]-β-d-glucopyranosyl-(1 → 4)-[β-d-glucopyranosyl-(1 → 2)]-α-l-arabinopyranosyl-3β,16α,28,30-tetrahydroxy-olean-12-ene (1), along with four known triterpenoids (2–5), was isolated from the rhizomes ofArdisia gigantifolia. Their structures were elucidated by spectroscopic methods. Compounds1–4showed cytotoxic activity against Hela, EJ, BCG, and HepG-2 cell lines. The percentage of early apoptotic cells after treatment with1was significantly increased compared with control cells (p < 0.05). [ABSTRACT FROM PUBLISHER]

Timosaponin BII (1), a steroidal saponin showing potential anti-dementia activity, was regioselectively hydrolyzed into its deglycosyl derivatives by the crude enzyme from Aspergillus niger AS 3.0739. Three biotransformation products, timosaponin BII-a (2), timosaponin BII-b (3), and timosaponin BII-c (4), were purified and their structures were elucidated on the basis of 1D NMR, 2D NMR, FAB-MS, and HR-ESI-MS spectral data. Compounds 2 and 3 are new compounds. [ABSTRACT FROM AUTHOR]

Two new isoflavone glycosides, mucodianins E (1) and F (2), have been isolated from the vine stems of Mucuna birdwoodiana Tutch. Their structures have been established as retusin 7-O-β-d-xylopyranosyl-(1 → 6)-β-d-glucopyranoside (1) and 8-O-methylretusin 7-O-β-d-xylopyranosyl-(1 → 6)-β-d-glucopyranoside (2) by means of spectroscopic analysis and chemical methods. [ABSTRACT FROM AUTHOR]