1. Extended thymectomy with blood vessel resection and reconstruction improves therapeutic outcome for clinical stage III thymic carcinoma patients: a real-world research.
- Author
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Liu, Lei, Zhang, Jiaqi, Wang, Guige, Guo, Chao, Chen, Yeye, Huang, Cheng, and Li, Shanqing
- Subjects
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THYMECTOMY , *BLOOD vessels , *OPERATIVE surgery , *PROGRESSION-free survival , *TREATMENT effectiveness , *CARCINOMA , *THYMUS tumors , *CARDIOVASCULAR surgery , *BLOOD-vessel tumors , *VENA cava superior , *THORACIC surgery , *RETROSPECTIVE studies , *METASTASIS , *TUMOR classification - Abstract
Objectives: We examine the therapeutic efficacy of extended thymectomy with blood vessel resection and reconstruction in thymic carcinoma patients with great vessel invasion.Methods: In total 26 patients diagnosed as clinical stage III thymic carcinoma with severe great vessel invasion were enrolled in this retrospective study. Among these patients, 14 cases received adjuvant chemo- and radiotherapy (non-operation subgroup, NOG), the other 12 patients received extended thymectomy with vessel resection and reconstruction followed by the adjuvant treatment (operation subgroup, OG).Results: All surgical procedures went smoothly with no perioperative death. R0 resection was obtained in all surgical cases, and we also observed a lymph node metastasis rate of 38.8%. The overall survival (OS) was 34 months for the whole cohort, 48 and 26 months for the OG and NOG respectively (p = 0.013). The median disease metastasis free survival (DMFS) was 47 months for the OG and 18 months for the NOG (p = 0.019).Conclusion: Extended thymectomy with vessel resection is feasible for patients with clinical stage III thymic carcinoma. Surgery significantly improves the overall survival and the prognosis of clinical stage III thymic carcinoma. [ABSTRACT FROM AUTHOR]- Published
- 2020
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