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1. Synthesis, crystal structure and antitumour activity of 4-(3-amino-4-morpholino-1H-indazole-1-carbonyl)benzonitrile.

Author

Jiu-fu Lu, Ling-xia Jin, Hong-guang Ge, Juan Song, Cai-bin Zhao, Xiao-hua Guo, Si-yu Yue, and Li Li

Subjects
*CANCER cells, *CELL lines, *BENZONITRILE, *RING formation (Chemistry), *HYDRAZINE
Abstract

The title compound, 4-(3-amino-4-morpholino-1H-indazole-1-carbonyl)benzonitrile was synthesised by condensation of 4-cyanobenzoic acid with 4-morpholino-1H-indazol-3-amine, which was prepared from 2,6-difluorobenzonitrile by amination with morpholine and then cyclisation with hydrazine hydrate. The crystal structure of the title compound was determined and the crystals belong to the monoclinic system, space group P21/c. In addition, the compound showed some inhibition of the proliferation of some cancer cell lines. [ABSTRACT FROM AUTHOR]

Published
2018
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