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• Solubility of p -Acetamidobenzoic acid in 12 pure solvents was determined. • Experimental solubility was correlated by the modified Apelblat equation, the λh model and the NRTL model. • The melting point of p -Acetamidobenzoic acid was estimated by the group contribution method. • Sigma profiles and solvation free energy were computed on the basis of COSMO-RS model. The solubility of p -Acetamidobenzoic acid (PAABA) in 12 pure organic solvents was measured using the gravimetric method in the temperature range of 283.15 K to 323.15 K. It was discovered that the solubility curves in different solvents cross each other when the temperature increased. Besides, the modified Apelblat equation, the λh model and the NRTL model were used to fit the measured solubility data of PAABA and the modified Apelblat equation and λh model gave the minor deviation compared with the NRTL model. The underlying mechanism between PAABA and solvent molecules was revealed in light of physical properties, sigma profiles and solvation free energy analysis, based on COSMO-RS model. The results indicated that the solubility of PAABA in most alcohol solvents are related to the value of solvation free energy. These data are helpful to further study the crystallization process of PAABA. [ABSTRACT FROM AUTHOR]

Solubility of 3MBA in fourteen mono-solvents was determined by gravimetric method and correlated by the modified Apelblat model, λ h model, van't Hoff model and NRTL model. The influence of different solvent property parameters on solubility was analyzed qualitatively and quantitatively. The calculated topological index (H) was used to explain the dissolution behavior firstly. COSMO-RS model was used to calculate the σ -profile and solvation free energy to reveal solubility trend in molecular level. [Display omitted] • Solubility of 3MBA in fourteen mono-solvents was determined and correlated. • The influence of different solvent property parameters on solubility was analyzed qualitatively and quantitatively. • The calculated topological index (H) was used to explain the dissolution behavior firstly. • COSMO-RS model was used to calculate the σ -profile and solvation free energy to reveal solubility trend in molecular level. A gravimetric method was used to determine the equilibrium solubility of 3-methoxybenzoic acid (3MBA) in 14 kinds of organic mono-solvents (methanol, ethanol, n-propanol, iso -propanol, n-butanol, iso -butanol, sec -butanol, formic acid, acetic acid, ethyl formate, methyl acetate, ethyl acetate, iso -propyl acetate, butyl acetate) from 278.15 K to 323.15 K at 0.1 MPa. In all the solvent systems studied, the solubility increases monotonously with the increasing of temperature. In addition, the effect of solvent properties on solid–liquid equilibrium of 3MBA was investigated. The results show that dissolving process of 3MBA in solvent is a complex process, which is affected by the action of solvent properties; Correlation analysis found that the solvent properties containing hydrogen bond donation (α), hydrogen bond acceptance (β), polarity index (E T 30 ), Hildebrand solubility parameter (δ H), cohesive energy density and surface tension process great influence on the dissolving behavior of 3MBA. And then, topological index (H) which can reflect the molecular structure information of the solvents was calculated. It was found that the solubility of 3MBA decreased with the increasing of H values in alcohol and ester solvents, and increased with the increasing of H values in carboxylic acid solvents. Besides, the solubility of 3MBA were related to the modified Apelblat model, λ h model, van't Hoff model and NRTL model, and the modified Apelblat model gave the best correlation results, with the ARD % of 0.68%. In addition, COSMO-RS model was used to calculate the σ -profiles and solvation free energy of selected solute–solvent systems, σ -profiles analysis was qualitatively described the intermolecular interaction, it was found that the solubility of 3MBA in the selected solvents was correlated with the solute–solvent intermolecular interactions; Solvation free energy was calculated in the "Molar" framework and found that the solubility of 3MBA in alcohols, esters and carboxylic acids decreased with the decreasing of the absolute value of the solvation free energy. [ABSTRACT FROM AUTHOR]