1. Determination and correlation of Avermectin B1a solubility in different binary solvent mixtures at temperatures from (283.15 to 313.15) K.
- Author
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Shen, Huan, Wu, Songgu, Liu, Yumin, Li, Kangli, Xu, Shijie, and Gong, Junbo
- Subjects
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SOLUBILITY , *AVERMECTINS , *GRAVIMETRIC analysis , *THERMODYNAMICS , *HEXANE , *DISSOLUTION (Chemistry) - Abstract
The solubility of Avermectin B 1a (AVM B 1a ) in the three binary solvent mixtures, (acetone + water), (acetone + n-hexane) and (isopropanol + n-hexane) was determined gravimetrically with the temperature ranging from 283.15 K to 313.15 K under atmospheric conditions. The experimental results indicate that the solubility of AVM B 1a increased with increasing temperature at certain solvent composition, and decreased with increasing mole fraction of water and n-hexane. Besides, the modified Apelblat equation, CNIBS/R-K model and Jouyban-Acree model were employed to correlate the solubility results obtained. All the selected models provide satisfactory results. Furthermore, the mixing thermodynamic properties were calculated based on the NRTL equation, a binary activity coefficient model. We also calculated the thermodynamic properties of the dissolution process of AVM B 1a . The calculated results indicate that the dissolution process of AVM B 1a in the tested solvents is endothermic and spontaneous. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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