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This paper examines the possible influence of external forcings on observed changes in precipitation extremes in the mid-to-high latitudes of Asia during 1958–2012 and attempts to identify particular extreme precipitation indices on which there are better chances to detect the influence of external forcings. We compare a recently compiled dataset of observed extreme indices with those from phase 5 of the Coupled Model Intercomparison Project (CMIP5) simulations using an optimal fingerprinting method. We consider six indices that characterize different aspects of extreme precipitation, including annual maximum amount of precipitation falling in 1 day (Rx1day) or 5 days (Rx5day), the total amount of precipitation from the top 5% or top 1% daily amount on wet days, and the fraction of the annual total precipitation from these events. For single-signal analysis, the fingerprints of external forcings including anthropogenic agents are robustly detected in most studied extreme indices over all Asia and for midlatitude Asia but not for high-latitude Asia. For two-signal analysis, anthropogenic influence is detectable in these indices over Asia at 5% or slightly less than 5% significance level, whereas natural influence is not detectable. In high-latitude Asia, anthropogenic influence is detected only in a fractional index, representing a stark contrast to the midlatitude and full Asia results. We find relatively smaller internal variability and thus higher signal-to-noise ratio in the fractional indices when compared with the other ones. Our results point to the need for studying precipitation extreme indices that are less affected by internal variability while still representing the relevant nature of precipitation extremes to improve the possibility of detecting a forced signal if one is present in the data. [ABSTRACT FROM AUTHOR]